The Immune System and Mental Health fully investigates how immune-related cellular, molecular and anatomical changes impact mental functioning. The book combines human and animal studies to reveal immunological changes related to mental-health problems. In addition, users will find comprehensive information on new research related to the microbial composition of the gut, aka, the microbiome, and how it influences brain function and mental health. Common comorbidities with mental illness and their inherent immunological or inflammatory components are also covered. Written by leaders in the field, the book synthesizes basic and clinical research to provide a thorough understanding on the role of immunity in neuropsychiatry.
Sociology, psychology, psychiatry, neuroscience and genetics have provided considerable explanations and solutions to some of the most intractable mental-health problems. But researchers are increasingly relying on investigations of the immune system to identify factors that can undermine and impair mental health. This book covers devastating mental-health conditions, such as depression, anxiety, schizophrenia, and autism-like spectrum disorders. In addition, degenerative disorders of the brain, such as Parkinson's and Alzheimer's-like dementia are explored.
- Considers both basic human and animal studies that address immunological changes relating to mental health problems across the lifespan
- Incorporates techniques, concepts and ideas from a variety of social, behavioral and life sciences
- Explores the relatively new area of the microbiome and how the microbial composition of the gut influences brain function and mental health
1. Multiple Neural and Endocrine Pathways Linked to Immune Functioning 2. The Immune System: Host Defense Against the Microbiological World 3. Lifestyle Factors Affecting Immune Functioning 4. Impact of Stressors on Non-Immune Biological Systems 5. Stress and Immunity 6. Depression 7. Anxiety Disorders and Posttraumatic Disorder 8. Depression and its Comorbidities 9. Autism-Spectrum Disorders 10. Schizophrenia 11. Neurodegenerative Disorders 12. Pain
Hymie Anisman is a Professor in the Department of Neuroscience at Carleton University, Ottawa, and also holds an adjunct appointment with the Institute of Mental Health Research (Royal Ottawa Hospital). Professor Anisman has been a Senior Ontario Mental Health Research Fellow, is a Fellow of the Royal Society of Canada, and has held a Canada Research Chair in Neuroscience since 2001. The principal theme of his research is the influence of stressors on neurochemical, neuroendocrine, and immune systems, and how these stressors influence psychological and physical (immune-related and neurodegenerative) disorders. His work has spanned studies using animal models to assess stress-related pathology as well as studies in humans to assess stress, coping, and appraisal processes. In addition to sitting on the editorial boards of several journals and on numerous grant panels, Professor Anisman has published more than 350 peer-reviewed journal papers, 40 book chapters, and several review papers within neuroscience and psychology journals; he has also published two authored textbooks, two edited books, and one trade book.
Alexander Kusnecov is a Professor of Psychology at Rutgers University. His research has consistently been funded by the National Institute of Mental Health and the National Institute for Drug Abuse, and has included research into the behavioral conditioning of the immune system, the effects of stress on immune function, and, at present, the effects of T-cell activation on central nervous system functions and behavior, as well as the effects of maternal immune activation with staphylococcal enterotoxins on neurobehavioral development in offspring. He has published more than 70 peer-reviewed articles in high profile journals such as Brain, Behavior and Immunity; Neuropsychopharmacology; Nature Medicine; Nature Neuroscience; and Journal of Neuroscience, and he coedited The Wiley-Blackwell Handbook of Psychoneuroimmunology (2013) with Hymie Anisman.
My research is focused upon how interactions between the brain and immune system may influence the development of psychiatric and neurological conditions. In particular, how stressors impact upon neuro-immune communication to promote emotional and behavioural disturbances. Current projects are also exploring how environmental factors and immune insults may cause brain inflammation that contributes to neurodegeneration.