Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field.
Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.
- Transcends multiple neural, neurochemical and behavioral domains
- Summarizes advances in the field of addiction research since the advent of optogenetics
- Discusses the most current, leading theories of addiction, including molecular mechanisms and dopamine mechanisms
1. Introduction 2. Neural Plasticity in Addiction 3. Neural Circuit Alterations in Addiction 4. Mechanisms Regulating Compulsive Drug Seeking 5. Glutamatergic Neuroplasticity Underlying Drug Reinstatement 6. Negative Reinforcement Mechanisms in Addiction 7. Role of Stress-Associated Signaling in Addiction 8. Circadian Regulation in Addiction 9. Sleep Mechanisms Regulating Addiction 10. Neural Ensemble Encoding of Addictive Behavior 11. Glial Dysregulation in Addiction 12. Role of the Extracellular Matrix in Addiction 13. Neural Morphology and Addiction 14. Interactions between Natural Rewards and Addiction 15. Cognitive Dysfunction in Addiction 16. Instrumental Learning Mechanisms in Addiction 17. Pavlovian Learning Mechanisms in Addiction 18. Molecular Mechanisms of Addiction: Current Theories 19. Emerging Neural Circuits Regulating Addiction 20. Dopamine Mechanisms in Addiction: Current Theories 21. Cell Type Specific Plasticity in Addiction 22. Neuropeptide Mechanisms in Addiction 23. Epigenetics and Addiction 24. Mechanisms for Harnessing Circuits for Treatment of Addictive Disorders 25. Conclusions and Future Directions
Mary Torregrossa has conducted research in the neuroscience of addiction field for 16 years, including studying opiates, psychostimulants, alcohol, and cannabinoids in addition to investigating the neural mechanisms underlying addiction and potential treatments using a variety of techniques, including behavioral analyses, pharmacology, microdialysis, biochemistry, molecular biology, and proteomics. Dr. Torregrossa began her career by earning her Ph.D. at the University of Michigan in the laboratory of Dr. James Woods, one of the "founding fathers of behavioral pharmacological studies of addictive disorders using animal models, and, as a postdoctoral fellow, trained with two other leaders in the addiction field, Dr. Peter Kalivas and Dr. Jane Taylor. Dr. Torregrossa is now an independent investigator in the Department of Psychiatry at the University of Pittsburgh, funded by the National Institute on Drug Abuse. She is the author of nearly 30 peer-reviewed articles in the field, as well as numerous reviews and book chapters.