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Quality Control and Evaluation of Herbal Drugs

  • ID: 4519370
  • Book
  • May 2019
  • 784 Pages
  • Elsevier Science and Technology
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Quality Control and Evaluation of Herbal Drugs brings together current thinking and practices for evaluation of natural products and traditional medicines. The use of herbal medicine in therapeutics is on the rise in both developed and developing countries and this book facilitates the necessary development of quality standards for these medicines.This book elucidates on various challenges and opportunities for quality evaluation of herbal drugs with several integrated approaches including metabolomics, chemoprofiling, marker analysis, stability testing, good practices for manufacturing, clinical aspects, Ethnopharmacology and Ethnomedicine inspired drug development.

Written by Prof. Pulok K Mukherjee, a leader in this field; the book highlights on various methods, techniques and approaches for evaluating the purity, quality, safety and efficacy of herbal drugs. Particular attention is paid to methods that assess these drugs' activity, the compounds responsible and their underlying mechanisms of action. The book describes the quality control parameters followed in India and other countries, including Japan, China, Bangladesh, and other Asian countries, as well as the regulatory profiles of the European Union and North America. This book will be useful in bio-prospecting of natural products and traditional medicine-inspired drug discovery and development.

  • Provides new information on the research and development of natural remedies - essential reading on the study and use of natural resources for preventative or healing purposes
  • Brings together current thinking and practices in quality control and standardization of herbal drugs highlighting several integrated approaches for metabolomics, chemo-profiling and marker analysis
  • Aids in developing knowledge of various techniques including macroscopy, microscopy, HPTLC, HPLC, LC-MS/MS, GC-MS etc. with the development of integrated methods for evaluation of botanicals used in traditional medicine
  • Assessment of herbal drugs through bio-analytical techniques, bioassay guided isolation, enzyme inhibition, pharmacological, microbiological, antiviral assays and safety related quality issues
  • References global organizations, such as the WHO, USFDA, CDSCO, AYUSH, TCM and others to serve as a comprehensive document for enforcement agencies, NGOs and regulatory authorities

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1. Traditional systems of medicines and harmonization 2. Ethnopharmacology and ethnomedicines-inspired drug development 3. Quality evaluation of herbal medicines: Challenges and opportunities 4. Qualitative analysis for evaluation of herbal drugs 5. Morphological and microscopical evaluations 6. Extraction and other downstream procedures for evaluation of herbal drugs 7. Bioactive phyto-components and their analysis 8. Thin layer chromatography for evaluation of herbal drugs 9. High performance thin layer chromatography (HPTLC) for analysis of herbal drugs 10. High performance liquid chromatography for analysis of herbal drugs 11. LC-MS: A rapid technique for understanding the plant metabolomic analysis 12. Chemo-profiling and marker analysis for quality evaluation of herbal drugs 13. Bioassay guided isolation and evaluation of herbal drugs 14. Enzyme inhibition studies for evaluation of herbal drugs 15. Evaluation of herbal drugs for antimicrobial and parasiticidal effects 16. Antiviral evaluation of herbal drugs 17. Plant metabolomics and quality evaluation of herbal drugs 18. Safety related quality issues for development of herbal drugs 19. Quality assurance of herbal drugs and stability testing 20. Phytopharmaceuitcals, nutraceuticals and their evaluation 21. Regulatory harmonization and good quality practices for development of herbal medicine

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Mukherjee, Pulok K.
Prof. Pulok K. Mukherjee is a fellow of the Royal Society of Chemistry (FRSC), UK and the fellow of the National Academy of Science (FNASc) India. He is working as the Director of the School of Natural Product Studies, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. His work on integrated approaches for traditional medicine-inspired drug development through chemo-profiling, quality control, pharmaco-vigilance, safety surveillance, risk assessment has achieved worldwide acclaim. He has made significant contributions in the area of evaluation and validation of medicinal plants, Ethnopharmacology, and ethnomedicine. He has contributed over 200 publications in peer reviewed impact journals and has several patents. He has also published several well acclaimed books including Evidence-Based Validation of Herbal Medicine (Elsevier); Evaluation of Herbal Medicinal Products (Pharmaceutical Press), and many others. Prof. Mukherjee has been honoured with several awards and laurels from both the Government of India and abroad. For further details please visit www.pulokmukherjee.in.
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