Brain Targeted Drug Delivery Systems. A Focus on Nanotechnology and Nanoparticulates

Table of Contents

1. Introduction and overview

Part I Physiology and principles for brain targeting drug delivery

2. Anatomy and physiology of blood-brain barrier

3. Recent progress in blood-brain barrier transportation research

4. In vitro and in vivo models of BBB to evaluate brain targeting drug delivery

Part II Nanoparticles-based brain targeting delivery strategies

5. Receptor-mediated transportation through BBB

6. Carrier-mediated transportation through BBB

7. Brain drug delivery by adsorption-mediated transcytosis

8. Efflux pump inhibition to enhance brain targeting delivery

9. Physically open BBB

10. Nanoparticle systems for nose-to-brain delivery

11. Brain local delivery strategy

Part III Nanoparticles-based brain targeting delivery for CNS disorder management

12.Glioma targeted delivery systems

13.Nanotherapeutic strategies for the treatment of neurodegenerative diseases

14. Savaging brain ischemia by increasing brain uptake of neuroprotectants

Part IV Perspective and pitfalls of nanoparticles-based brain targeting delivery

15. Neurotoxicity concern about the brain targeting delivery systems

16. The intra-brain distribution of brain targeting delivery systems

17. The elimination of brain-targeted nanomaterials

18. Perspective on brain targeting drug delivery systems

Authors

Huile Gao Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, China. Dr. Huile Gao received his PhD in Pharmaceutics from School of Pharmacy, Fudan University in 2013 under the supervision of Prof. Xinguo Jiang. Then he joined the West China School of Pharmacy, Sichuan University as an Instructor in July 2013 and was promoted to an Associate Professor in July 2014. Dr. Gao's research interests focus on the design, synthesis, characterization and evaluation of stimuli responsive nanomaterials for drug and imaging probe delivery to improve treatment and diagnosis of human diseases especially tumor and brain diseases. He has published over 50 peer-reviewed articles. His research is supported by National Natural Science Foundation of China (81373337, 81402866), Excellent young scientist foundation of Sichuan University (2015SCU04A14) and 4 other grants. His doctorial dissertation has been awarded as Excellent Doctorial Dissertation of Shanghai in 2015. He was awarded as "Young Excellent Pharmaceutics Scientist” in 2015. Xiaoling Gao Department of Pharmacology and Chemical Biology, Faculty of Basic Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Xiaoling Gao is a Professor at Department of Pharmacology and Chemical Biology, Shanghai Jiaotong University School of Medicine. Her research has been focused on developing novel nanomedicines and nanoparticulate drug delivery systems for the management of brain diseases, especially Alzheimer's disease and glioma. She has authored or co-authored more than 50 papers in peer-reviewed journals, which have been cited more than 1500 times. Her work has been highlighted in ACS Nano Perspective and reported by Chemical and Engineering News. She received the nomination award of China Top 100 Excellent Doctoral Dissertations in 2009, and won the 2nd prize for Progress in Science and Technology awarded by Chinese Pharmaceutical Association in 2010. As a main contributor, she also won the 1st Prize for Progress in Science and the 1st Prize for Progress in Technology, awarded by the Chinese Ministry of Education. In 2017, she won the Excellent Youth Award from the National Natural Science Foundation, and was enrolled in National Youth Talent Support Program.