Helicases from All Domains of Life is the first book to compile information about helicases from many different organisms in a single volume. Research in the helicase field has been going on for a long time now, but the completion of so many genomes of these ubiquitous enzymes has made it difficult to keep up with new discoveries. As the huge number of identified DNA and RNA helicases, along with the structural and functional differences among them, make it difficult for the interested scholar to grasp a comprehensive view of the field, this book helps fill in the gaps.
- Presents updates on the functions and features of helicases across the different kingdoms
- Begins with a chapter on the evolutionary history of helicases
- Contains specific chapters on selected helicases of great importance from a biological/applicative point-of-view
1. Archaea helicases: Unwinding in the extreme 2. Structure and function of Helicases in Archaea the third domain of life 3. Role of plant helicases in imparting salinity stress tolerance to plants 4. Evolution of RNA helicases in plants: molecular and functional insights 5. Genome wide in-silico identification of helicases from Leishmania donovani 6. Genome wide in-silico characterization of Ded1 family of helicases from Plasmodium falciparum 7. Overview of Post translational modifications of biochemically characterized Plasmodium falciparum helicases 8. Role of Human Xeroderma pigmentosum Group D (XPD) helicase in various cellular pathways 9. Diverse Roles of DEAD/DEAH-box Helicases in Immunity and Disease 10. Role of zinc-binding domain of RecQ helicases 11. Helicase dysfunctions in human diseases 12. A general model of DNA unwinding by monomeric helicases 13. Assaying the activity of Helicases: An Overview 14. An Overview of AAA+ superfamily proteins associated helicases
Renu Tuteja received her BS in Chemistry, Botany and Zoology from the University of Lucknow, India. She also received her MS in Biochemistry from the University of Lucknow, India. She did her Ph.D. in Chemistry at the University of Kanpur, India. She is presently National Officer and Group Leader for Parasite Biology at the International Center for Genetic Engineering and Biotechnology (ICGEB), in New Delhi India.