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Non-Enzymatic Protein Modifications in Health, Disease and Ageing

  • ID: 4540003
  • Book
  • November 2018
  • 252 Pages
  • Elsevier Science and Technology

Non-Enzymatic Protein Modifications in Health, Diseases and Ageing discusses each type of non-enzymatic protein, introducing non-enzymatic protein modifications, reviewing the state-of-the-art, and presenting updates and current trends. The book covers various aspects of the subject, including the formation and removal of modified proteins, their roles in disease, preventative methods, and possible roles in cellular signaling. This book not only provides well-established facts, but also discusses current hypotheses and controversies.

  • Provides the basic chemical knowledge necessary to understand non-enzymatic protein modifications
  • Combines a systematic chemical introduction to non-enzymatic protein modifications
  • Presents the types of non-enzymatic proteins that are usually separately reported and reviewed
  • Considers current hypotheses and controversies alongside the facts
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1. Chemistry of non-enzymatic protein modifications
2. Methods for detection and quantification of non-enzymatic protein modifications
3. Non-enzymatic protein modifications under physiological conditions
4. Possible role of non-enzymatic protein modifications in cellular signalling
5. Altered non-enzymatic protein modifications in diseases and their pathogenic roles
6. Accumulation of products of non-enzymatic protein modification in aging and their potential role in aging
7. Prevention of non-enzymatic protein modifications and of their effects
8. Non-enzymatic protein modifications during food and feed preparation and storage, and their effect on food and feed quality
9. Summary: what to expect?
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Sadowska-Bartosz, Izabela
Izabela Sadowska-Bartosz is Assistant Professor in the Department of Biochemistry and Cell Biology, at the University of Rzeszów in Poland. Her research focusses on non-enzymatic protein modifications, their roles in disease and aging, and their prevention. She has published widely on the topic, and received the title of Dr.habil for her work on 'Prevention of selected non-enzymatic modifications of proteins by natural and synthetic antioxidants'
Bartosz, Grzegorz
Grzegorz Bartosz is a Professor and Head of the Molecular and Biophysics Department, and the Department for Membrane Biophysics at the Faculty of Biology and Environmental Protection at the University of Lodz in Poland. He has published widely in the field.
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