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Quorum Sensing. Molecular Mechanism and Biotechnological Application

  • Book

  • April 2019
  • Elsevier Science and Technology
  • ID: 4612871
Quorum sensing (QS) is a process of bacterial cooperative behaviour that has an effect on gene regulation. This cell-to-cell communication system involves the production of signalling molecules according to cell density and growth stage. Virulence, the ability to infest a habitat and cause disease, is also governed by such communication signals.

Quorum Sensing: Molecular mechanism and biotechnological application collects, describes and summarizes the most interesting results obtained from experts working on QS mechanisms. It contributes to the understanding of the molecular basis that regulates this mechanism, and describes new findings in fields of application. This volume describes the QS mechanism from its molecular basis to medical applications such as antibiotic therapy and involvement of QS in pathologies. This reference also analyzes its potential use in biotechnological applications such as food packaging, drug delivery, and marine biofilm. The broad scope of this title will be of significant use to researchers across several fields with interest in QS, including to microbiologists, chemists, biochemists and ecologists.

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Table of Contents

1. GENERAL: CHEMISTRY AND MICROBIOLOGY 1. The Chemical Language Of Gram-Negative Bacteria 2. Analytical approaches for the identification of quorum-sensing molecules 3. Quorum sensing in marine biofilms and environments 4. Quorum sensing in extremophiles

2. INTER-KINGDOM COMMUNICATION 5. Quorum Sensing in Phytopathogenesis 6. Quorum sensing and gut microbiome

3. QUORUM SENSING INHIBITION 7. Enzymatic Quorum Quenching in Biofilms 8. Effect of Polyphenols on Microbial Cell-Cell Communications

4. APPLICATIONS 9. Pseudomonas aeruginosa Quorum Sensing and Biofilm Inhibition

10. Cyclic Peptides in Neurological Disorders: The Case of Cyclo(His-Pro)


Giuseppina Tommonaro Biologist, Institute of Biomolecular Chemistry, National Research Council of Italy. Giuseppina Tommonaro, biologist, is a highly-experienced researcher based at one of Italy's leading research institutions: The Institute of Biomolecular Chemistry, at the National Research Council. Her research activity concerns the extraction, isolation and the chemical characterization of secondary metabolites biologically active from natural source. Marine organisms, in particular sponges, plants and marine microorganisms are objects of her studies. In particular, she is involved in the isolation and characterization of natural products produced from sponge -and plant- associated microorganisms, with particular attention to metabolites involved in Quorum Sensing mechanism. Dr. Tommonaro was involved in the chemical characterization of polysaccharides and biopolymers extracted from bacteria and vegetables. During her research activity, she has developed a sound experience in the isolation and structural elucidation of natural compounds, as well as in the chemical derivation of bioactive compounds to improve the biological activity.