Biotin and Other Interferences in Immunoassays: A Concise Guide is aimed at clinical laboratory scientists, medical technologists and pathologists who are often the first individuals contacted by a clinician when a laboratory test result does not correlate with clinical presentation. Research scientists working in diagnostics companies will also find this information essential. Sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratory are also discussed so readers can get all important information from one concise guide. This succinct, user-friendly reference provides the necessary information to address high levels of biotin in clinical laboratory results.
- Discusses issues of biotin interferences and ways to avoid them for accurate clinical laboratory results
- Provides sources of errors in non-immunoassay based methods used in clinical chemistry and toxicology laboratories
- Highlights how to handle specimens in the lab and how to eliminate the effect of biotin in precious samples
1. Immunoassay design and mechanism of biotin interference 2. Biotin: Pharmacology, Pathophysiology and Assessment of Biotin Status 3. Biotin: From Supplement to Therapy 4. Effect of Biotin on Clinical Laboratory Test Results: How to Avoid such Interferences? 5. Issues of Interferences in Clinical Chemistry Tests including Heterophilic Antibody Interferences 6. Issues of Interferences in Therapeutic Drug Monitoring 7. Issues of Interference in Drugs of Abuse Testing and Toxicology
Amitava Dasgupta received his PhD degree in Chemistry from Stanford University and his fellowship training in Clinical Chemistry from the Laboratory Medicine Department of the University of Washington School of Medicine at Seattle. He is a tenured Full Professor of Pathology and Laboratory Medicine at the University of Texas Health Sciences Center located at the Texas Medical Center at Houston. Dr. Dasgupta has published 210 scientific papers, written many invited review articles, and has edited, co-edited or written 15 books. He is on the Editorial Board of five major medical journals including American Journal of Clinical Pathology, Archives of Pathology and Laboratory Medicine, Therapeutic Drug Monitoring, Clinica Chimica Acta and Journal of Clinical Laboratory Analysis.