Neuroscience of Nicotine: Mechanisms and Treatment presents the fundamental information necessary for a thorough understanding of the neurobiological underpinnings of nicotine addiction and its effects on the brain. Offering thorough coverage of all aspects of nicotine research, treatment, policy and prevention, and containing contributions from internationally recognized experts, the book provides students, early-career researchers, and investigators at all levels with a fundamental introduction to all aspects of nicotine misuse.
With an estimated one billion individuals worldwide classified as tobacco users-and tobacco use often being synonymous with nicotine addiction-nicotine is one of the world's most common addictive substances, and a frequent comorbidity of misuse of other common addictive substances. Nicotine alters a variety of neurological processes, from molecular biology, to cognition, and quitting is exceedingly difficult because of the number of withdrawal symptoms that accompany the process.
- Integrates cutting-edge research on the pharmacological, cellular and molecular aspects of nicotine use, along with its effects on neurobiological function
- Discusses nicotine use as a component of dual-use and poly addictions and outlines numerous screening and treatment strategies for misuse
- Covers both the physical and psychological effects of nicotine use and withdrawal to provide a fully-formed view of nicotine dependency and its effects
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1. Understanding Tobacco Use in Different Countries 2. Maternal Smoking and Fetal Brain Outcome: Mechanisms and Possible Solutions 3. Nicotine Effects in Adolescents 4. The Impact of Traditional Cigarettes and ECigarettes on the Brain 5. Reduction of Nicotine in Tobacco and Impact 6. Prenatal Nicotine Exposure and Neuronal Progenitor Cells 7. Synaptically Located Nicotinic Acetylcholine Receptor Subunits in Neurons Involved in Dependency to Nicotine 8. Cotinine as a Possible Allosteric Modulator of Nicotine Effects in Various Models 9. Nicotine, Neural Plasticity, and Nicotine's Therapeutic Potential 10. Habenular Synapses and Nicotine 11. Nicotine Neuroprotection of Brain Neurons: The Other Side of Nicotine Addiction 12. Linking Nicotine, Menthol, and Brain Changes 13. Cigarette Smoking and Nicotine: Effects on Multiple Sclerosis 14. Tobacco and Positron-Emission Tomography (PET) of the Dopaminergic System: A Review of Human Studies 15. Resting-State Functional Connectivity Imaging and Nicotine Dependence 16. Functional Magnetic Resonance Imaging of Acute Nicotine Effects 17. Nicotine Dependence in Schizophrenia: Contributions of Nicotinic Acetylcholine Receptors 18. Attentional Bias and Smoking 19. Effects of Nicotine on Inhibitory Control in Humans 20. Nicotine, Corticotropin-Releasing Factor, and Anxiety-Like Behavior 21. 6-Hydroxy-L-Nicotine and Memory Impairment 22. Cotinine and Memory: Remembering to Forget 23. Nicotine in Aberrant Learning and Corticostriatal Plasticity 24. Prenatal Nicotine Exposure and Impact on the Behaviors of Offspring 25. Craving in Substance Use Disorders With a Focus on Cigarette Smoking 26. The Acute Effect of Exercise on Cravings and Withdrawal Symptoms 27. CRF2 Receptor Agonists and Nicotine Withdrawal 28. Delirium and Nicotine Withdrawal 29. Postoperative Nicotine Withdrawal 30. Nicotine and Alpha3beta2 Neuronal Nicotinic Acetylcholine Receptors 31. Nicotine Addiction and Alpha4beta2* Nicotinic Acetylcholine Receptors 32. The Medial Habenula-Interpeduncular Nucleus Pathway in Nicotine Sensitization: The Role of ?3?4 Nicotinic Acetylcholine Receptors and Substance P 33. Targeting Nicotinic Acetylcholine Receptors for the Treatment of Pain 34. Pharmacology of Muscle-Type Nicotinic Receptors 35. Involvement of Opioid Receptors in Nicotine-Related Reinforcement and Pleasure 36. Nicotine-Induced Kindling: Influences of Age, Sex, and Prevention by Antioxidants 37. Nicotine Reward and Abstinence: Role of the CB1 Receptors 38. The Therapeutic Potential of the Cognitive- Enhancing Effects of Nicotine and Other Nicotinic Acetylcholine Receptor Agonists 39. Nicotine and Dopamine DA1 Receptor Pharmacology 40. Brain Gene Expression in the Context of Nicotine Rewards: A Focus on Cholinergic Genes 41. HIV-Infected Subjects and Tobacco Smoking: A Focus on Nicotine Effects in the Brain 42. Renin-Angiotensin System Genes and Nicotine Dependence 43. Nicotine Dependence and the CHRNA5/CHRNA3/CHRNB4 Nicotinic Receptor Regulome 44. Brain, Nrf2, and Tobacco: Mechanisms and Countermechanisms Underlying Oxidative-Stress-Mediated Cerebrovascular Effects of Cigarette Smoking 45. Effects of Nicotine and Histone Deacetylase Inhibitors on the Brain 46. L-Type Calcium Channels and Nicotine 47. The Co-occurrence of Nicotine With Other Substance Use and Addiction: Risks, Mechanisms, onsequences, and Implications for Practice,With a Focus on Youth 48. Comorbid Smoking and Gambling Disorder: Potential Underlying Mechanisms and Future Explorations 49. Neuroscience of Tobacco and Crack Cocaine Use: Metabolism, Effects, and Symptomatology 50. Salivary Cotinine Assays 51. Overview of Cotinine Cutoff Values for Smoking Status Classification 52. Smoking Abstinence Expectancies Questionnaire 53. Pharmacist-led Smoking Cessation Services: Current and Future Perspectives 54. Nicotine Use and Weight Control in Young People: Implications for Prevention and Early Intervention 55. Exercise as a Smoking Cessation Aid 56. Varenicline: Treating Smoking Addiction and Schizophrenia 57. Nicotine Vaccines: The Past, the Present, and the Future 58. Treating Nicotine Dependence in Psychiatric Hospitals 59. Oral 18-Methoxycoronaridine (18-MC) Decreases Nicotine Self-Administration in Rats 60. Pharmacogenetics and Smoking Cessation 61. The Orexin System and Nicotine Addiction: Preclinical Insights 62. Tobacco Control Policies and Smokers' Responses 63. Resources for the Neuroscience of Nicotine
Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a staff member of the Faculty of Life Sciences and Medicine within King's College London. He is also a member of the Division of Diabetes and Nutritional Sciences (research) and the Department of Nutrition and Dietetics (teaching). Professor Preedy is also Director of the Genomics Centre of King's College London.
Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctorate (DSc), for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. Professor Preedy has carried out research when attached to Imperial College London, The School of Pharmacy (now part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. Prof Preedy is a leading expert on the science of health and has a long standing interest in neurological disease and tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.