DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more.
- Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases
- Presents data that is targeted to a very wide audience of specialists, researchers and students
- Contains timely chapters written by well-renowned authorities in their field
- Provides targeted information that is well supported by a number of high-quality illustrations, figures and tables
how DNA packaging controls double-strand break repair Iva Ugrinova 4. Controlling the balance between chromosome breaks repair pathways Pablo Huertas 5. The targeting of DNA repair pathways in the era of precision oncology Eddy S. Yang 6. Cancer cells repair and deal with DNA replication stress Marcel A.T.M. van Vugt 7. Claspin: from DNA damage responses to cancer therapy Teresa C. Martins 8. cAMP-mediated regulation of melanocyte genomic instability: a melanoma-preventive strategy John J. D'Orazio 9. Mechanistic link between DNA Repair factors and Immune Signaling Asaithamby Aroumougame 10. DNA base excision repair in infection-induced inflammation Min Wu