DNA Repair, Vol 115. Advances in Protein Chemistry and Structural Biology

  • ID: 4622059
  • Book
  • 383 Pages
  • Elsevier Science and Technology
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DNA Repair, Volume 115, the latest release in the Advances in Protein Chemistry and Structural Biology series, provides an overview of current developments in mechanisms underlying DNA repair, their involvement in maintaining chromatin repair, the balance between chromosome breaks repair pathways, tumorigenesis, immune signaling and infection-induced inflammation. Specific chapters cover the Structure and function of the multi-subunit TFIIH with insights into nucleotide excision repair, Chromatin repair: how DNA packaging controls double-strand break repair, Controlling the balance between chromosome breaks repair pathways, The targeting of DNA repair pathways in the era of precision oncology, and much more.

  • Describes advances in our understanding on DNA repair mechanisms and the involvement of their dysregulation in promoting diseases
  • Presents data that is targeted to a very wide audience of specialists, researchers and students
  • Contains timely chapters written by well-renowned authorities in their field
  • Provides targeted information that is well supported by a number of high-quality illustrations, figures and tables

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1. DNA repair by photolyases Ibrahim Halil Kavakli, Nuri Ozturk and Seref Gul 2. TFIIH: A multi-subunit complex at the cross-roads of transcription and DNA repair Olga Kolesnikova, Laura Radu, and Arnaud Poterszman 3. Chromatin control in double strand break repair Anastas Gospodinov and Iva Ugrinova 4. Controlling the balance between chromosome break repair pathways Sonia Jimeno, Fernando Mejías-Navarro, Rosario Prados-Carvajal and Pablo Huertas 5. Targeting DNA repair in precision medicine Reena Beggs and Eddy S. Yang 6. Replication stress: Driver and therapeutic target in genomically instable cancers Pepijn M. Schoonen, Sergi Guerrero Llobet and Marcel A.T.M. van Vugt 7. Claspin: From replication stress and DNA damage responses to cancer therapy Diana Azenha, Maria Celeste Lopes and Teresa C. Martins 8. cAMP-mediated regulation of melanocyte genomic instability: A melanoma-preventive strategy Nathaniel C. Holcomb, Robert-Marlo Bautista, Stuart G. Jarrett, Madeline Krentz Gober, Katharine M. Carter and John A. D'Orazio 9. Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling Shibani Mukherjee, Salim Abdisalaam, Souparno Bhattacharya, Kalayarasan Srinivasan, Debapriya Sinha and Aroumougame Asaithamby 10. Elucidating the role of interacting residues of the MSH2-MSH6 complex in DNA repair mechanism: A computational approach D. Thirumal Kumar, B. Susmita, E. Judith, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed 11. A computational model to predict the structural and functional consequences of missense mutations in O6-methylguanine DNA methyltransferase Thirumal Kumar D., Enid Mendonca, J. Priyadharshini Christy, C. George Priya Doss and Hatem Zayed
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