Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming.
As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics.
- Provides a foundational overview of epigenetics in regenerative medicine
- Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice
- Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways
- Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine
Section I: Epigenetics: molecular players and mechanisms 2. Dynamics and mechanisms of DNA methylation reprogramming 3. Histone modifications 4. Non-coding RNAs 5. Nuclear structure and 3D organization of the genome
Section II: Development, Reprogramming & Tissue regeneration 6. Epigenetics of early mammalian development 7. Somatic Cell Epigenetic Reprogramming: Molecular Mechanisms and Therapeutic Potential 8. Regenerative potential across species
Section III: Regenerative medicine: The epigenetics of tissue homeostasis, repair and regeneration 9. Common challenges in tissue regeneration 10. Epigenetic Mechanisms in Liver and Pancreas Generation and Regeneration 11. Transcriptional mechanisms controlling intestinal cell fate 12. Heart regeneration 13. Skeletal muscle regeneration in physiological and pathological conditions 14. Regeneration of the skeletal system and dental tissue 15. Neural tissue regeneration 16. Insights into the epigenetics of retinal development and diseases 17. Epigenetics of regeneration with a focus on organoids
Section IV: Epigenetics, regeneration and environment 18. Epigenetic pharmacology in regenerative medicine (epi-drugs) 19. Regenerative potential with age: The epigenetic clock and tissue rejuvenation 20. Epigenetics and life style: the impact of stress, diet and social habits in tissue homeostasis
Section V: Conclusive remarks 21. Ethical considerations 22. Epigenetics and Regeneration: looking towards the future