Modern Applications of Cycloaddition Chemistry examines this area of organic chemistry, with special attention paid to cycloadditions in synthetic and mechanistic applications in modern organic chemistry. While many books dedicated to cycloaddition reactions deal with the synthesis of heterocycles, general applications, specific applications in natural product synthesis, and the use of a class of organic compounds, this work sheds new light on pericyclic reactions by demonstrating how these valuable tools elegantly solve synthetic and mechanistic problems. The work examines how pericyclic reactions have been extensively applied to different chemistry areas, such as chemical biology, biological processes, catalyzed cycloaddition reactions, and more.
This work will be useful for organic chemists who deal with organic chemistry, medicinal chemistry, agrochemistry and material chemistry.
- Provides details on the synthesis of antiviral and anticancer compounds, marking the key role of unconventional catalyzed cycloaddition reactions for preparing new derivatives in a unique reaction pathway that is scalable in industrial processes
- Contains the most up-to-date review of the use of pericyclic reactions in drug delivery
- Includes the enzyme-catalyzed processes involving cycloaddition reactions for different targets, demonstrating that cycloaddition is more common in nature than expected
- Features new applications for cycloadditions in material chemistry and provides a general view of the most recent results in the area
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1. Cycloaddition Reactions for Antiviral Compounds 2. Cycloaddition Reactions for Anticancer Compounds 3. Drug Delivery and Cycloaddition Reactions 4. Natural Strategies in Cycloaddition Reactions 5. Cycloaddition Reactions in Material Chemistry
Dr. Paolo Quadrelli is Professor in the Department of Chemistry, University of Pavia, Pavia, Italy. Prof. He graduated in Chemistry at the University of Pavia in 1986, magna cum laude, and conducted his PhD research in Chemical Sciences at the University of Pavia. From November 1989 to June 1992, Dr. Quadrelli worked in R&D Laboratories of the Eniricerche SpA Company (ENI Group), San Donato Milanese (MI), operating in the field of heterogeneous catalysis and developing a superacidic original catalyst for the reactions isomerization of n-alkanes and alkylation. He is author of a Patent, EP 0520543 - 1992, dealing with the preparation of novel solid superacid catalysts. In 1992, Dr. Quadrelli joined the Department of Organic Chemistry, Faculty of Sciences, University of Pavia, as Researcher in Organic Chemistry. From November 1996 to October 1997 Dr. Quadrelli was Marie Curie Fellow at the School of Chemistry, University of Leeds (Great Britain) in the research group of Prof. Ronald Grigg. During this period, the research focused on the themes of the Palladium as a catalyst for chemical cascade and 1,3-dipolar cycloadditions of azomethine ylides, conducted both in solution and on solid phase. He was appointed Associate Professor in 2010 and in 2017 he was promoted to Full Professor in Organic Chemistry. He is a member of the American Chemical Society (ACS) as well as member of the board of referees of Eur. J. Org. Chem., J. Org. Chem., ARKIVOC, and regional editor of The Scientific Journal of Chemistry. He is author of more than 90 papers. Prof. Quadrelli is Head of the Organic Chemistry section of the Department of Chemistry in Pavia and Vice-President of the Didactic Council for the Degree in Chemistry.