Synaptic transmission is the process by which neurons communicate with one another at synapses, which is essential for normal function of the central and peripheral nervous systems. Synaptic dysfunction is linked to a number of conditions affecting the nervous system, including schizophrenia, Alzheimer's disease, Parkinson's disease, impairments in muscle control, and other neurological disorders. Synaptic Transmission is a comprehensive guide to the topic of neurotransmission, providing an in-depth discussion of many aspects of synapse structure and function, a fundamental part of the neuroscience discipline. Chapters include boxes that describe renowned/award-winning researchers and their contributions to the field of synaptic transmission, diseases relevant to the material presented, details of experimental approaches used to study synaptic transmission, and interesting asides that expand on the topics covered. This book will inspire students to appreciate how the basic cellular and molecular biology of the synapse can lead to a better understanding of nervous system function and neurological disorders, training future researchers and clinicians in this critical discipline.
- A comprehensive reference on synaptic structure, physiology, function, and neurotransmission
- Discusses many landmark experiments in the field of synaptic transmission to emphasize core principles
- Chapters include references to primary scientific literature, relevant review articles, and books, many of which could be assigned as discussion material for courses focused on this topic
Part 1: Synaptic Biophysics and Nerve Terminal Structure 2. The formation and Structure of Synapses 3. Basics of Cellular Neurophysiology 4. Ion Channels and Their Role in Generating Action Potentials 5. Electrical Synapses
Part 2: Regulation of Chemical Transmitter Release 6. Function of Chemical Synapses and the Quantal Theory of Transmitter Release 7. Calcium Homeostasis, Calcium Channels, and Transmitter Release 8. Cellular and Molecular Mechanisms of Exocytosis 9. Cellular and Molecular Mechanisms of Endocytosis and Synaptic Vesicle Trafficking
Part 3: Receptors and Signaling 10. Introduction to Receptors 11. Ionotropic Receptors 12. Metabotropic G-protein-coupled Receptors and Their Cytoplasmic Signaling Pathways 13. Synaptic Integration Within Postsynaptic Neurons 14. Synaptic Plasticity
Part 4: Chemical Transmitters 15. Introduction to Chemical Transmitter Systems 16. Acetylcholine 17. Monoamine Transmitters 18. Amino Acid Neurotransmitters 19. Neuropeptide Transmitters 20. Gaseous Neurotransmitters 21. The Use of Multiple Neurotransmitters at Synapses 22. Complex Signaling Within Tripartite Synapses
Dr. Meriney is Professor of Neuroscience and Psychiatry at the University of Pittsburgh. He completed his Ph.D. in Physiology / Neuroscience with Dr. Guillermo Pilar at the University of Connecticut studying the development of parasympathetic synapses that innervate the intrinsic eye muscles. He then moved on to postdoctoral training in synaptic physiology at UCLA under the direction of Dr. Alan Grinnell where he used the neuromuscular junction as a model system to study presynaptic mechanisms of transmitter release. At the University of Pittsburgh, he has developed a research program focused on neurotransmitter release, plasticity, and diseases of the synapse, including the development of a new class of calcium channel gating modifiers with therapeutic potential to treat various neuromuscular disorders that result in weakness. Dr. Meriney has received grant support for this research from the National Institutes of Health, the National Science Foundation, the American Heart Association, and the Muscular Dystrophy Association. Dr. Meriney has developed and taught several undergraduate courses at the University of Pittsburgh including Developmental Neuroscience and Synaptic Transmission, that both serve a relatively large class of undergraduates majoring in Neuroscience. He is also currently the co-director for the graduate program within the Center for Neuroscience at the University of Pittsburgh, a multi-departmental cross campus PhD training program.
Dr. Fanselow completed her Ph.D. in neurobiology with Dr. Miguel Nicolelis at Duke University, where she studied the function of the thalamocortical loop in the rodent somatosensory system. Additionally, she pioneered methods for using trigeminal nerve stimulation as a treatment for epilepsy. She then did a postdoctoral fellowship with Dr. Barry Connors at Brown University, where her research focused on neurophysiological aspects of synaptic connectivity and the roles inhibitory neurons play neuronal networks. Her findings apply both to understanding the basic function of neocortical circuitry and to the pathology of epilepsy. Dr. Fanselow was an Assistant Professor in the Department of Neurobiology at the University of Pittsburgh, where her lab focused on the physiological roles of inhibitory synapses in neocortical circuitry. During this time, she also had the opportunity to teach neurophysiology to graduate and medical students. Dr. Fanselow has worked as an independent consultant on neuroelectrophysiological recording techniques, and is currently a full-time instructor in the Department of Neuroscience at the University of Pittsburgh. She teaches multiple undergraduate courses to neuroscience majors, including Synaptic Transmission, Functional Neuroanatomy, Drugs and Behavior, Introduction to Neuroscience, and several advanced neuroscience electives focusing on the anatomical and neurobiological bases for neurological disorders.