Human Embryos and Preimplantation Genetic Technologies. Ethical, Social, and Public Policy Aspects

Table of Contents

1. The challenge for medical ethicists: Weighing pros and cons of advanced reproductive technologies to screen human embryos during IVF
Inmaculada de Melo-Martin
2. Too much information? The paradox of enlarging genetic datasets for human embryo assessment during in vitro fertilization (IVF)
Shachar Zuckerman and Gheona Altarescu
3. A new global perspective: Geographic variations in the use of preimplantation genetic technologies to screen human embryos
Alexander M. Quaas
4. Elective gender selection of human embryos during IVF: Ethical and public policy considerations
Gab Kovacs
5. Embryo mosaicism and its impact on IVF decisionmaking when using preimplantation genetic screening: Current challenges and controversies
Gon Shoham, Yuval Yaron and Ariel Weissman
6. Genetic counseling for preimplantation genetic testing (PGT): Practical and ethical challenges
Emily L. Mounts and Andria G. Besser
7. Psychological and interpersonal factors in preimplantation embryo assessment
Timothy Bracewell-Milnes, Jara Ben-Nagi and Meen-Yau Thum
8. Nonideal theory, self-respect, and preimplantation genetic technologies
Clair Morrissey and Elena Neale
9. Fate of non-transferred screened embryos from IVF: Current challenges and future directions
Alice J. Shapiro, Catherine Shea and Vitaly A. Kushnir
10. The Islamic perspective: Application of advanced reproductive technologies to screen human embryos during IVF
Gamal I. Serour and Ahmad G.I. Serour
11. An Orthodox Jewish approach to ethical and social aspects of embryo testing
Gideon Weitzman, Lior Segev and Benjamin David
12. The Australia experience: Cultural and political factors shaping human embryo assessment during in vitro fertilization
Brette Blakely, Tereza Hendl and Sheryl de Lacey
13. The Belgian experience: Cultural and political factors shaping preimplantation genetic diagnosis during in vitro fertilization
Guido Pennings and Heidi Mertes
14. The Brazil experience: Evolution and future trajectories of public health policy regarding human embryo assessment
Fernanda Souza Peruzzato and Juliana Cuzzi
15. The Chilean experience: Cultural and political factors shaping human embryo assessment during IVF
Fernando Zegers-Hochschild and Juan Enrique Schwarze
16. The Croatian experience: Cultural and political factors shaping human embryo assessment during assisted reproductive technology
Tamara Tramisak Milakovic and Ivana Milas Klaric
17. The Ireland experience: Cultural and political factors shaping the development of regulation of assisted human reproduction, ethical status of human embryos, and proposed regulation of surrogacy
Evelyn Mahon
18. The Thailand experience: Cultural and political factors shaping human embryo assessment during IVF
Patsama Vichinsartvichai
19. The Ukraine experience: Preimplantation testing of human embryos
Lyuda V. Shkrobot
20. Mitochondrial replacement therapy: Ethical, sociocultural, and public policy considerations
Shelley Dolitsky and Mark V. Sauer
21. Editing human reproduction? Legal and ethical aspects of genome editing
Judit Sandor

Authors

E. Scott Sills Senior Vice President for Research, Gen 5 Fertility Center, La Jolla, California USA Department of Obstetrics & Gynecology, Palomar Medical Center, Escondido, California USA Applied Biotechnology Research Group, University of Westminster, London, UK. Dr. Scott Sills is Senior Vice President for Research at Gen 5 Fertility in La Jolla, Califormia. In addition to full-time IVF practice, Dr. Sills' research portfolio focuses on reproductive genetics, bioethics, minimal access fertility surgery, and health policy. At G5F, Dr. Sills continues to standardize ovarian 'rejuvenation' using autologous platelet-rich plasma, following the first registered clinical trial of its kind for which he was Principal Investigator (2017-2018). Dr. Sills is a Vanderbilt graduate and received his PhD from London's University of Westminster. He was awarded the MD degree from University of Tennessee in 1992, followed by gynecology residency at NYU Downtown Hospital and a sub-specialty fellowship in reproductive endocrinology at Cornell University-New York Presbyterian Hospital. He is board certified both by the American Board of Obstetrics & Gynecology and the National Board of Physicians & Surgeons. Dr Sills is a Fellow of the American College of Obstetricians & Gynecologists, American College of Surgeons, and the Royal College of Physicians (Ireland), with medical credentials in California, New York and the United Kingdom. Gianpiero D. Palermo Center for Reproductive Medicine and Infertility, Weill Medical College of Cornell University, NY, USA. Gianpiero D. Palermo, MD, PhD is Director of Assisted Fertilization and Andrology at the Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine (CRM), Professor of Embryology in Obstetrics & Gynaecology, and the Blavatnik Distinguished Professor of Reproductive Medicine at Weill Cornell Medical College. Dr. Gianpiero Palermo is internationally known as an innovator in reproductive medicine, having developed intracytoplasmic sperm injection (ICSI), a revolutionary procedure in which a single sperm is injected directly into the egg for fertilization. In recognition of his ground-breaking contribution to reproductive medicine, he has received prestigious awards, including the Serono Prize for Medical Research on chromosomal analysis of embryos; the Barbara Eck Menning Founder's Award from RESOLVE, the national infertility organization; the Shackman Memorial Lecture at Johns Hopkins; the Buckeye Lecture of the American Society of Andrology; the Jacob Heskel Gabbay Award in Biotechnology and Medicine; and the Russian Crystal Tube Award. His current research includes molecular and genetic aspects of fertilization, follow-up of ICSI babies, and genetic aspects of male infertility, as well as devising new procedures to treat age-related female infertility, harvesting and differentiation of embryonic stem cells and in vitro maturation of male germ cells.