Nanostructured Biomaterials for Regenerative Medicine focuses on the definition of new trends for the design of biomaterials for biomedical applications. It includes the ex novo synthesis as well as technological strategies to manipulate them into appropriate two-dimensional (2D) and three-dimensional (3D) forms, in order to impart all the main physical, chemical, structural and biological properties requested to achieve desired clinical efficacy. This book aims at offering a concise overview of innovative platforms based on nanostructured biomaterials as a function of their chemical nature - established by a consolidated material classification i.e., polymer, ceramics and metals. For each class, emerging bioinspired systems with rapid expansion in the biomedical research area and fabricated via new enabling technologies will be proposed for the use in tissue repair/regeneration and nanomedicine.
This book is an essential resource for researchers, academics and professionals interested in the potential of nanostructured biomaterials for regenerative medicine.
- Classifies materials into three classes for comprehensive discussion
- Discusses design techniques to create innovative nanostructured biomaterials
- Looks at enabling technologies and strategies for emerging applications
1. Introducing biomaterials for tissue repair and Regeneration 2. Regulatory landscape of nanostructured biomaterials for tissue regeneration 3. Nanostructured biomaterials: future perspectives in clinical use 4. Nanostructured biomaterials with antimicrobial activity for tissue engineering
Polymers and composites 5. Molecularly imprinted polymers for controlled release in regenerative medicine 6. Polysaccharide based hybrid materials for protein release 7. Patterned nanocomposites for hierarchical tissue regeneration
Ceramics 8. Nanostructured synthetic calcium phosphates for hard tissue engineering and nanomedicine 9. Silicate based nanoceramics in regenerative medicine 10. Bioactive glass-ceramics: from macro to nano 11. Inorganic nanoparticle based biomaterials for regenerative medicine
Metals 12. Surface topographies on the micro and nanoscale for guided tissue regeneration on metal alloys 13. Fast and effective osseointegration of dental, spinal and orthopaedic implants through tailored chemistry of inorganic surfaces 14. Micro and nano-needles as innovative approach in nanomedicine 15. Metal nanoscale systems functionalized with organic compounds
Vincenzo Guarino is Research Scientist at Institute of Polymers, Composite and Biomaterials of the Italian National Research Council since January 2006. He is Scientific Responsible of the Electrospinning and Microscopy labs at IPCB UOS Napoli/Portici (2014-today) and Scientific Co-Responsible of Lamest (Scanning and Transmission Electron Microscopy labs) at IPCB Pozzuoli since 2016. Currently, he is scientific responsible of the project 3DNeuroglia, financially supported by the Air Force Office of Scientific Research (AFOSR)(2018-2020), PI for the Italy in the CNR/NRC bilateral cooperation (2018-2019) and Scientific Responsible of research activities with leader R&D companies (Procter & Gamble, Dompè Pharmaceuticals). He is also supervisor/co-supervisor of PhD students co-founded by INCIPIT H2020 Marie Sklodowska-Curie project (Grant n. 665403). His main research interests include polymer and composite biomaterials for scaffold design, electro-fluid-dynamic technologies (i.e, electrospinning, electrospraying, electro dynamic atomization) for the fabrication of micro/nanofibres, particles and micro-nanostructured coatings/interfaces for biomedical applications (i.e., tissue engineering, drug delivery, nanomedicine). To date, he is author/co-author of over 100 indexed publications, 22 chapters in International books, 2 patents and over 200 contributions to international/national conferences.
Michele Iafisco is a researcher at Institute of Science and Technology for Ceramics (ISTEC) of the National Research Council (CNR) in Faenza (RA), Italy since 2013. He graduated in Chemistry in 2005 from the Alma Mater Studiorum, University of Bologna. From the same university he obtained the Ph.D. degree in Chemical Science in April 2009. His research interests include biomaterials, biomineralization, nanomedicine, calcium phosphates and bioceramics. He has authored more than 90 papers in international peer-reviewed journals, 15 book chapters and 6 patents. He is member of the editorial boards of several international journals and expert evaluator for the European Commission and for other European research agencies. In 2015 he was recipient of the prize "Ricercatamente 2014 for the best research activity of most promising young researcher "under 35 at the National Research Council of Italy in the field "Chemical Sciences and Materials Technology" and of the IUPAC-2015 Young Chemist Travel Award. From 01/01/2016, he is scientific responsible of the Research Line on "Nanostructured materials for dental and maxillofacial applications of the ISTEC-CNR.
Prof. S. Spriano is Associate Professor at the Applied Sciences and Technology Department of Politecnico di Torino (DISAT - POLITO). She has 20 years experience in metallic materials and biomaterials, in particular her research activities cover: surface modification and characterization of metallic alloys for biomedical applications, functionalization of biomaterials with natural biomolecules, bioactivity, shape memory and pseudo-elastic alloys, antibacterial and anti-fouling surfaces, surfaces with enhanced osteointegration ability, surface for guided soft tissues generation, low friction composite materials with graphene/nano-graphite and coatings for materials for high wear and/or fretting resistance.