Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others.
In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care.
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Table of Contents
1. Introduction to systems medicine 2. Genomics 3. Proteomics 4. Metabolomics 5. Microbiomics 6. Functional "Omics for systems medicine 7. Analytic methods for systems medicine 8. Epigenetics and oral diseases 9. Systems medicine in periodontal disease 10. Oral and systemic health 11. Systems medicine in the diseases of the bone 12. Systems medicine and salivary gland diseases 13. Systems medicine and neuropathic oral diseases 14. Systems medicine in oral oncology 15. Systems medicine and autoimmune diseases 16. Stem cells and regenerative medicine 17. Practical considerations applications 18. Conclusion and future directions