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Translational Systems Medicine and Oral Disease

  • Book
  • September 2019
  • Elsevier Science and Technology
  • ID: 4753530

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others.

In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care.

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Table of Contents

1. Introduction to systems medicine 2. Genomics 3. Proteomics 4. Metabolomics 5. Microbiomics 6. Functional "Omics” for systems medicine 7. Analytic methods for systems medicine 8. Epigenetics and oral diseases 9. Systems medicine in periodontal disease 10. Oral and systemic health 11. Systems medicine in the diseases of the bone 12. Systems medicine and salivary gland diseases 13. Systems medicine and neuropathic oral diseases 14. Systems medicine in oral oncology 15. Systems medicine and autoimmune diseases 16. Stem cells and regenerative medicine 17. Practical considerations applications 18. Conclusion and future directions


Stephen T. Sonis Professor and Chairman, Department of Oral Medicine and Diagnostic Sciences, Harvard School of Dental Medicine, Chief, Division of Oral Medicine, Oral and Maxillofacial Surgery and Dentistry, Dana-Farber Cancer Institute, Boston, Massachusetts. Dr. Sonis is senior academic at Harvard, Brigham and Women's Hospital and the Dana-Farber Cancer Institute and a world-renowned expert in epithelial injury associated with cancer therapy. His development of predictive animal models has enabled the investigation of the biological basis of cancer regimen-related epithelial injury and has catalyzed the development of potential therapies. Dr. Sonis' interest in the genomic basis for toxicity risk and its pathology has led to innovative genomics-based analytical approaches to clinically actionable outcomes to personalize disease therapy. He has published extensively on the clinical, biological, and health economic aspects of cancer and complications associated with its treatment. Steve holds several patents and is the author of more than 275 original publications, reviews, and chapters and is completing his eleventh book. He obtained degrees from Tufts and Harvard and completed his post-doctoral education (tumor immunology) at Oxford University where he was a Knox Fellow. Allessandro Villa Associate Surgeon, Brigham and Women's Hospital and Dana-Farber Cancer Institute; Instructor in Oral Medicine, Program Director for Oral Medicine Residency Program, Harvard School of Dental Medicine, Boston, MA, USA. Dr. Alessandro Villa is an Associate Surgeon at Brigham and Women's Hospital and Dana-Farber Cancer Institute. He also holds an appointment as Instructor in Oral medicine at the Harvard School of Dental Medicine where he serves as the Program Director for the Oral Medicine Residency Program. Dr. Villa studied dental medicine at the University of Milano, and obtained a PhD from the University of Sassari, Italy. He obtained his Master of Public Health from AT Still University, MO. He completed a surgical residency in oral medicine at Brigham and Women's Hospital/Harvard School of Dental Medicine and a post-doctoral fellowship in cancer epidemiology and genetics at the National Cancer Institute at the National Institutes of Health in Bethesda, MD. Dr. Villa is board certified in Oral Medicine. His clinical interests include the treatment of oral mucosal diseases, salivary gland disorders and oral complications from cancer therapy. Dr. Villa's research interests are focused primarily on potentially malignant disorders of the oral cavity and oral toxicities from cancer treatment. Dr. Villa has published widely on topics in oral medicine and is the author of over 40 research papers, reviews and chapters. He serves on the editorial boards of both the World Journal of Stomatology and the American Journal of Oral Medicine.