Principles of Bone Biology, Fourth Edition, remains the essential resource for anyone involved in the study of bones. It is the most comprehensive, complete, up-to-date source of information on all aspects of bones and bone biology. Assembled by experts from around the world, this book is designed for students interested in the field, young investigators at the graduate and post-graduate level beginning their research careers, and scientists investigating skeletal disorders who need to enrich their research programs.
- Includes a repository of knowledge for anyone involved in the study of bone biology
- Provides a one-stop source written by experts in the field
B. Biochemistry 13. Type I Collagen Structure, Synthesis, and Regulation; 14. Collagen Cross-Linking and Metabolism; 15. Noncollagenous Bone Matrix Proteins (including osteopontin); 16. Bone Proteinases; 17. Integrins and Other Cell Surface Attachment Molecules of Bone Cells; 18. Intercellular Junctions and Cell-Cell Communication in the Skeletal System
C. Bone Remodeling and Mineral Homeostasis 19. Histomorphometric Analysis of Bone Remodeling; 20. Phosphorus Homeostasis and Related Disorders; 21. Magnesium Homeostasis; 22. Metals in Bone: Aluminum, Boron, Cadmium, Chromium, Lanthanum, Lead, Silicon, and Strontium; 23. Biology of the Extracellular Ca2+-Sensing Receptor
D. Endocrine and Paracrine Regulation of Bone 24. Parathyroid Hormone: Molecular Biology; 25. Paracrine PTHrP in Bone: Physiology and Pharmacology; 26. Actions of Parathyroid Hormone on the Vasculature and Cardiovascular System and Vascular, Cardiovascular, and Neurological Actions of Parathyroid-Related Protein; 27. PTH and PTHrP Actions on Kidney; 28. Receptors for Parathyroid Hormone (PTH) and PTH-Related Protein; 29. 1?,25(OH)2 Vitamin D3Vitamin D Nuclear Receptor (VDR) and Plasma Vitamin D-Binding Protein (DBP) Structures and Ligand Shape Preferences for Genomic and Rapid Biological Responses; 30. Vitamin D Gene Regulation; 31. Noncalcemic Actions of Vitamin D; 32. Cellular Actions of Parathyroid Hormone; 33. Calcitonin peptides; 34. Regulation of Bone Remodeling by Central and Peripheral Nervous System
E. Other Systemic Hormones that Influence Bone Metabolism 35. Estrogens and Progestins; 36. Physiological Actions of Parathyroid Hormone (PTH) and PTH-Related Protein: Epidermal, Mammary, Reproductive, Pancreatic Tissues; 37. The Pharmacology of Selective Estrogen Receptor Modulators; 38. Thyroid Hormone and Bone; 39. Clinical and Basic Aspects of Glucocorticoid Action in Bone 40. Effects of Diabetes and Insulin on Bone Physiology; 41. Androgens Receptor Expression and Steroid Action in Bone
F. Local Regulators 42. Insulin-like Growth Factors and the IGF Binding Proteins: Implications for Bone Biology; 43. Platelet-Derived Growth Factor and the Skeleton; 44. Notch Signaling and its Ligands; 45. Fibroblast Growth Factor (FGF) and FGF Receptor Families in Bone; 46. Vascular Endothelial Growth Factor and Osteogenic-Angiogenic Coupling; 47. Transforming Growth Factor-?; 48. Bone Morphogenetic Proteins and the Skeleton and Bone Morphogenetic Protein Receptors and Actions; 49. Non-Skeletal Actions of RANK Ligand; 50. Local Regulators of Bone: IL-1, TNF, Lymphotoxin, Interferon-?, the LIF/IL-6 Family, and Additional Cytokines; 51. Prostaglandins and Bone Metabolism
PART II Molecular Mechanisms of Metabolic Bone Disease 52. Molecular Actions of PTH1R and their implications; 53. Multiple Endocrine Neoplasia Type 1; 54. Parathyroid Hormone-Related Peptide and Other Systemic Factors in Skeletal Manifestations of Malignancy; 55. Localized Osteolysis; 56. Genetic Regulation of Parathyroid Gland Development; 57. Genetic Disorders Caused by PTH/PTHrP Receptor Mutations; 58. Molecular Basis of PTH Overexpression; 59. Diseases Resulting from Defects in the G Protein Gs?; 60. Renal Osteodystrophy: Pathogenic Mechanisms and Therapeutic Options; 61. Osteogenesis Imperfecta; 62. Hereditary Deficiencies in Vitamin D Action; 63. FGF 23; 64. Tumor-Induced Osteomalacia; 65. Osteopetrosis; 66. Hypophosphatasia: Nature's Window on Alkaline Phosphatase Function in Humans; 67. Paget's Disease of Bone; 68. Genetic Determinants of Bone Mass and Osteoporotic Fracture / Genomic Approaches in Skeletal Research
PART III Pharmacological Mechanisms of Therapeutics 69. Pharmacological Mechanisms of Therapeutics: Parathyroid Hormone; 70. Calcium; 71. Drugs Acting on the Calcium Receptor: Calcimimetics and Calcilytics; 72. Bisphosphonates: Mechanisms of Action; 73. Pharmacologic basis of RANK L inhibition; 74. Pharmacologic basis of Sclerostin Inhibition; 75. Vitamin D and Analogues; 76. Mechanisms of Exercise
PART IV Methods in Bone Research 77. Application of Genetically Modified Animals in Bone Research; 78. Biochemical Markers of Bone Metabolism; 79. Microimaging; 80. Macroimaging; 81. Methods in Lineage Tracing; 82. Histomorphometry in Rodents; 83. Bone Strength Testing in Rodents; 84. Endocrinology of Bone
Dr. Bilezikian is Chief of the Division of Endocrinology and Director of the Metabolic Bone Diseases Program at Columbia University Medical Center. He belongs to the American Society for Bone and Mineral Research (President 1995-1996), and the International Society of Clinical Densitometry (President, 1999-2001). He serves on the Board of Governors of the International Osteoporosis Foundation (1998-present) and on its Committee of Scientific Advisors (2001-present) and is Chair of the Endocrine Fellows Foundation. He served as Editor-in-Chief of the Journal of Clinical Endocrinology and Metabolism (2000-2004) and as Senior Associate Editor of the Journal of Bone and Mineral Research (2008-2012). He is Executive Advisory Editor of Bone Research (2013-present). He served as co-chair of the last three NIH Workshops on Primary Hyperparathyroidism (2002, 2008, 2013).
Dr. Bilezikian is the recipient of the Distinguished Physician Award of the Endocrine Society, the Frederic C. Bartter Award of the American Society for Bone and Mineral Research (ASBMR) for Excellence in Clinical Research and the First Annual Global Leadership Award of the International Society of Clinical Densitometry. In 2009, he received the Gideon A. Rodan Excellence in Mentorship Award from the ASBMR. He received the Laureate Distinguished Educator Award of The Endocrine Society in 2014. In 2014, he was made honorary member of the Brazilian Society of Endocrinology and Metabolism. His publications number over 700.
Martin, T. John
Dr. Martin has served on 12 state and national committees and boards, been an international lecturer for nearly 20 years, and his work has been extensively published in a total of 420 original papers, 178 reviews, chapters and editorials, and seven books. He was appointed as Officer of the Order of Australia, elected to fellowships of the Australian Academy and the Royal Society and received 12 prestigious career awards, including the Eric Susman Prize from the Royal Australasian College of Physician. He has had 12 patents granted and held eight international visiting appointments in the United Kingdom, United States, and Switzerland. An outstanding contribution to science includes the cloning of parathyroid hormone related protein.
Clemens, Thomas L.
Thomas Clemens works at the Johns Hopkins University in the Department of Orthopaedic Surgery, Baltimore, MD, USA
Dr. Rosen is Professor and Senior Scientists at The Jackson Laboratory, Bar Harbor, Maine, where his group studies the role of insulin-like growth factors on bone and the genetics of osteoporosis in inbred strains of mice. In 2007 he joined the Maine Medical Center Research Institute in Scarborough, Maine. He is also the former Director of the Maine Center for Osteoporosis Research and Education, St. Joseph Hospital, Bangor.
Dr. Rosen is a Past President of the American Society of Bone and Mineral Research (ASBMR). He served five years as the First Editor in Chief of the Journal of Clinical Densitometry, the official journal for the International Society of Clinical Densitometry, and currently serves as Associate Editor of the Journal of Bone and Mineral Research. His publications exceed 270 manuscripts published in a wide spectrum of clinical and basic science journals.