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Carbonic Anhydrases. Biochemistry and Pharmacology of an Evergreen Pharmaceutical Target

  • Book

  • July 2019
  • Elsevier Science and Technology
  • ID: 4759490

Carbonic Anhydrases provides an interdisciplinary review of the burgeoning carbonic anhydrase (CA) research area, spanning from CAs classification (biochemical and structural features) to drug design and pharmacology of CA inhibitors and activators, finally touching on the biotechnological applications of these metalloenzymes. The book adopts a clear step-by-step approach and introduction to this intricate and highly interdisciplinary field. A diverse range of chapters from international experts speak to CA classification and distribution, the mechanisms of action and drug design of inhibitors and activators, the druggability of the various isoforms in the treatment of a multitude of diseases, and threats to human health.

Carbonic Anhydrases provides biology, biochemistry, and medicinal chemistry students and researchers a thorough discussion and update on the evergreen and expanding research area of CAs.

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Table of Contents

1. Carbonic Anhydrases: An Overview
2. a-Carbonic Anhydrases
3. �-Carbonic Anhydrases
4. ?-Carbonic Anhydrases
5. d-Carbonic Anhydrases
6. ?-Carbonic Anhydrases
7. ? and ?-Carbonic Anhydrases
8. Human Carbonic Anhydrases: Tissue Distribution, Physiological Role and Druggability
9. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Zinc Binders
10. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Anchor to The Zinc-Bound Nucleophile
11. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds Occluding the Entrance of The Active Site
12. Mechanisms of Action of Carbonic Anhydrase Inhibitors: Compounds That Bind "Out of The Binding Site� And Compounds with An Unknown Mechanism of Action
13. Carbonic Anhydrase Inhibitors as Ophthalmologic Drugs for The Treatment of Glaucoma
14. Carbonic Anhydrase Inhibitors as Diuretics
15. Carbonic Anhydrase Inhibitors for The Treatment of Epilepsy and Obesity
16. Carbonic Anhydrase Inhibitors for The Treatment of Tumors: Therapeutic, Immunologic, And Diagnostic Tools Targeting Isoforms IX And XII
17. Carbonic Anhydrase Inhibitors for The Treatment of Neuropathic Pain and Arthritis
18. Carbonic Anhydrases from Pathogens: Bacterial Cas And Their Inhibitors as Potential Anti-Infectives
19. Carbonic Anhydrases from Pathogens: Fungal Cas And Their Inhibitors as Potential Antifungal Agents
20. Carbonic Anhydrases from Pathogens: Protozoan Cas And Related Inhibitors as Potential Anti-Protozoal Agents
21. Carbonic Anhydrase Activators and Their Potential in The Pharmaceutical Field
22. Biotechnological Applications of Carbonic Anhydrases from Extremophiles
23. CO2 Capture by Engineered Mammalian Carbonic Anhydrases

Authors

Claudiu T. Supuran Full Professor, University of Florence, Neuroscience, Psychology, Medicine and Child Health, Florence, Italy. Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields. Alessio Nocentini Post-doc Researcher, Department of Neuroscience, University of Florence, Italy. Dr. Alessio Nocentini currently works at the Department of Neuroscience, University of Florence, Italy. He recently concluded his PhD thesis, which dealt with several aspects of carbonic anhydrase, spanning from drug-design, synthesis of inhibitors, and molecular modeling to biological evaluations of carbonic anhydrase modulators. He is now a post-doctoral researcher in Professor Supuran's research team.