Metalloenzymes. From Bench to Bedside

Table of Contents

1. Introduction to metalloenzymes

Section II 2. Magnesium and calcium-containing enzymes

Section III 3. Zinc enzymes

Section IV. Other metalloenzymes 4. Manganese enzymes 5. Nickel enzymes 6. Iron enzymes (heme-containing) 7. Iron enzymes (non-heme containing, Fe(II) or Fe(III) proteins) 8. Copper enzymes 9. Cadmium enzymes 10. Molybdenum enzymes 11. Tungsten-containing enzymes

Authors

Claudiu T. Supuran Full Professor, University of Florence, Neuroscience, Psychology, Medicine and Child Health, Florence, Italy. Dr. Claudiu T. Supuran received his BSc in chemistry from the Polytechnic University of Bucharest, Romania (1987) and PhD in chemistry at the same university in 1991. In 1990, he became Assistant and then Associate Professor of Chemistry at the University of Bucharest. He was Visiting Scholar at the University of Florida, Gainesville, United States, at Griffith University, Brisbane, Australia, and Visiting Professor at University of La Plata, Argentina. In 1995 he moved to the University of Florence, Italy, where he is currently Full Professor in the Department of Neuroscience, Psychology, Medicine and Child Health. His main research interests include design of enzyme inhibitors and activators, heterocyclic chemistry, chemistry of sulfonamides, sulfamates, and sulfamides, biologically active organo-element derivatives, QSAR studies, X-ray crystallography of metallo-enzymes, metal complexes with biologically active ligands (metal-based drugs), carbonic anhydrases, cyclooxygenases, serine proteases, matrix metalloproteinases, bacterial proteases, and amino acid derivatives among others. He has published more than 1900 papers in these fields. William Alexander Donald Associate Professor, School of Chemistry, University of New South Wales, Sydney, Australia. Dr. William Alexander Donald is an academic and research group leader in the School of Chemistry at the University of New South Wales, Australia. His research interests include carbonic anhydrases, coordination chemistry, and the development of bioanalytical methodologies for improving drug discovery and development. He has published more than 120 papers in these fields.