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Smell and Taste, Vol 164. Handbook of Clinical Neurology

  • ID: 4768659
  • Book
  • November 2019
  • Region: Global
  • 504 Pages
  • Elsevier Science and Technology
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Smell and Taste, Volume 164 focuses on recent clinical research regarding two of our primary chemical senses, smell and taste. This volume is the most comprehensive neurology book on disorders of smell and taste function. Its major sections include epidemiology, anatomy and physiology, and clinical assessment, including neuroimaging, clinical conditions affecting smell and taste function (e.g., autoimmune disorders, head trauma, diseases of the nose and mouth, etc.). The widespread use of olfactory testing in clinical trials searching for biomarkers of neurodegenerative diseases is reviewed, along with evidence that smell dysfunction can be an early marker in neurodegenerative diseases and autoimmune disorders.

  • Covers all aspects of disorders of taste and smell for beginning students of various disciplines (neurology, psychiatry, neuropsychology, otolaryngology)
  • Teaches that smell and taste testing can be useful in differential diagnosis and can assess brain regions not normally assessed by traditional neurological or neuropsychological tests
  • Addresses, in detail, recent evidence that smell loss is a better predictor of future mortality than dementia and even heart disease
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SECTION I. BASIC PRINCIPLES A. Fundamentals 1. Epidemiology of smell and taste dysfunction

B. Morphophysiology of the olfactory and nasal trigeminal sensory systems 2. Anatomy of the olfactory system 3. Development of the human olfactory system 4. Anatomy of the olfactory mucosa 5. Olfactory receptor function 6. Central olfactory structures 7. Taste and smell processing in the brain 8. The intranasal trigeminal system 9. Cranial nerve 13

C. Morphophysiology of the gustatory and oral trigeminal systems 10. Anatomy and development of the human taste system 11. Taste receptor function 12. Central taste anatomy and physiology 13. The orotrigeminal system

SECTION II. CLINICAL ASPECTS A. Clinical assessment 14. Health histories and medical evaluations of patients with complaints of chemosensory dysfunction 15. Psychophysical testing of smell and taste function 16. Electrophysiological assessment of olfactory and gustatory function 17. Neuroimaging of smell and taste

B. Diseases and disorders 18. Diseases of the nasal cavity 19. Neurolocalization of taste disorders 20. Chemosensory dysfunction in neurodegenerative diseases 21. Systemic diseases and disorders 22. Toxic exposures and the senses of taste and smell 23. The influence of head injury on olfactory and gustatory function 24. Animal models of olfactory dysfunction in neurodegenerative diseases

C. Treatment and management of chemosensory disorders 25. Treatments for smell and taste disorders: A critical review

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Doty, Richard L.
Richard L. Doty, M.S., Ph.D., is the Director of the University of Pennsylvania's Smell and Taste Center, and Professor within the Department of Otorhinolaryngology: Head and Neck Surgery. He is an editorial consultant to over 50 scientific and medical journals and to dozens of major corporations and governmental advisory committees. Dr. Doty is author or coauthor of over 400 professional publications (including 12 books). He is perhaps best known for having invented the University of Pennsylvania Smell Identification Test or UPSIT (commercially known as the Smell Identification TestTM), the first widely used standardized olfactory test. This test, which has been heralded as "the eye chart of the nose,” has been administered to an estimated half million persons since its introduction in the 1980s and has been translated into over 30 different languages. Among his numerous awards are the James A. Shannon Award from the National Institutes of Health (1996), the Olfactory Research Fund's Scientific Sense of Smell Award (2000), the William Osler Patient-Oriented Research Award from the University of Pennsylvania (2003), the Society of Cosmetic Chemist's Service Award (2004), and the Association for Chemoreception Science's Max Mozell Award for Outstanding Achievement in the Chemical Senses (2005). Dr. Doty is an elected Fellow of the College of Physicians and Surgeons (1983), the American Association for the Advancement of Science (2005), the Royal College of Medicine (2008), Association for Psychological Science (2009), and the American Academy of Neurology (2017).
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