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Stress Resilience

  • ID: 4772120
  • Book
  • 240 Pages
  • Elsevier Science and Technology
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Stress Resilience: Molecular and Behavioral Aspects presents the first reference available on the full-breadth of cutting-edge research being carried out in this field. It includes a wide range of basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance, but also focuses on the molecular and cellular mechanisms underlying stress resilience. World-renowned experts provide chapters that cover everything from the neural circuits of resilience, the effects of early-life adversity, and the transgenerational inheritance of resilience.

This unique and timely book will be a go-to resource for neuroscientists and biological psychiatrists who want to improve their understanding of the consequences of stress and on how some people are able to avoid it.

  • Approaches resilience as a process rather than as a static trait
  • Provides basic molecular knowledge on the potential associations between resilience phenomenon and biochemical balance
  • Presents thorough coverage of both the genetic and environmental factors that contribute to resilience
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1. Stress Resilience and Neuronal Plasticity 2. Resilience as a Process Instead of a Trait 3. Cognitive and Behavioral components of Resilience to Stress 4. The brain mineralocorticoid receptor: A resilience factor for psychopathology? 5. GABAB Receptors and Stress Resilience: A Tale of Two Isoforms 6. Sex Differences in Programming of Stress Resilience 7. Active Resilience in Response to Traumatic Stress 8. Rhythmic Regulation of Stress Resilience 9. The Role of Low Anxiety and/or Brain Bioenergetics in Stress Resilience 10. Understanding Resilience:  Biological Approaches in At-Risk Populations 11. Stress Resilience as a Consequence of Early-life Adversity 12. Mechanisms by which Early-life Experiences Promote Enduring Stress Resilience or Vulnerability 13. The Role of Child Abuse and Neglect in Stress Responsivity/ Resilience 14. How Genes and Environment Interact to Shape Risk and Resilience to Stress-Related Psychiatric Disorders. 15. Molecular Characterization of the Resilient Brain: Transcriptional and Epigenetic Mechanisms 16. The Role of the CRF-Urocortin System in Stress Resilience 17. Transgenerational Inheritance of Resilience from Preclinical to Clinical 18. Intergenerational Transmission of Stress Vulnerability and Resilience in Humans 19. Neural Circuits of Stress Resilience 20. The Neuro-connectomics of Stress Resilience 21. Stress-linked Psychopathologies 22. Maladaptive learning and the amygdala
prefrontal circuits: from genes to spikes

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Chen, Alon
Professor Alon Chen is Director and Scientific Member at the Max Planck Institute of Psychiatry in Munich, Germany. In parallel, he is Head of the Department of Neurobiology at Weizmann Institute of Science, Rehovot, Israel. Alon also serves as the Head of the Max Planck Society - Weizmann Institute of Science Laboratory for Experimental Neuropsychiatry and Behavioral Neurogenetics.
Alon's research focuses on the Neurobiology of Stress, particularly the mechanisms by which the brain is regulating the response to stressful challenges and how this response is linked to psychiatric disorders. The collective long-term goal of his research is to elucidate the pathways and mechanisms by which stressors are perceived, processed, and transduced into neuroendocrine and behavioral responses under healthy and pathological conditions.
Alon's lab has made significant discoveries in his field, including fundamental aspects of the organism's stress response and linking the action of specific stress-related genes, epigenetic mechanisms and brain circuits with anxiety disorders, depression, eating disorders and the metabolic syndrome. Alon and his team use both genetic mouse models and human patients to ultimately create the scientific groundwork for therapeutic interventions to treat stress-related behavioral and physiological disorders.
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