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esuberaprost

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    Report

  • 17 Pages
  • October 2018
  • Region: Global
  • Citeline
  • ID: 4775226
Drug Overview
Esuberaprost (United Therapeutics) is an oral chemically stable prostacyclin analog targeting the prostaglandin I2 (PGI2) receptor.

Analyst Outlook
United Therapeutics has ceded a large advantage in the time required to develop and formulate esuberaprost as an oral prostacyclin. The pulmonary hypertension (PH) market now contains both Uptravi (selexipag; Johnson & Johnson/Nippon Shinyaku) and Orenitram (treprostinil; United Therapeutics) to occupy the oral prostacyclin niche, leaving esuberaprost a much narrower potential indication to be used as an adjunctive to inhaled Tyvaso (treprostinil; United Therapeutics/Mochida). This narrow therapeutic role, combined with questions surrounding esuberaprost’s efficacy, leaves the drug with restricted commercial potential

Table of Contents

OVERVIEW
Drug Overview
Product Profiles
esuberaprost : Pulmonary hypertension
LIST OF FIGURES
Figure 1: Esuberaprost for pulmonary hypertension – SWOT analysis
Figure 2: The authors drug assessment summary of esuberaprost for pulmonary hypertension
Figure 3: The authors drug assessment summary of esuberaprost for pulmonary hypertension
Figure 4: Esuberaprost sales for pulmonary hypertension in the US, 2016–25
LIST OF TABLES
Table 1: Esuberaprost drug profile
Table 2: Esuberaprost Phase II data in pulmonary arterial hypertension
Table 3: Esuberaprost Phase III trials in pulmonary arterial hypertension
Table 4: Esuberaprost sales for pulmonary hypertension in the US ($m), 2016–25