Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described.
Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models.
- Includes case studies of other organs on a chip that have been developed and successfully used
- Provides insights into functional microphysiological organ on a chip platforms for toxicity and efficacy testing, along with opportunities for translational medicine
- Presented fields (PK/PD, physiology, medicine, safety) are given a definition followed by the challenges and potential of organs on a chip
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1. Need for alternative testing methods and opportunities for organ-on-a-chip systems 2. Cell sources and methods for producing organotypic in vitro human tissue models 3. Organs-on-a-chip engineering
Part I Organ-on-a-chip platforms to model disease pathogenesis 4. Lung-on-a-chip platforms for modeling disease pathogenesis 5. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease 6. Brain-on-a-chip systems for modeling disease pathogenesis 7. Kidney-on-a-chip 8. Heart-on-a-chip 9. Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping 10. Gut-on-a-chip microphysiological systems for the recapitulation of the gut microenvironment 11. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems
Part II Multi-organs-on-a-chip platforms to mimic humans physiology 12. Design and engineering of multiorgan systems 13. 8.b. Human body-on-a-chip systems 14. Automation and opportunities for industry scale-up of microphysiological systems 15. How to build your multiorgan-on-a-chip system: a case study
Dr. Hoeng is Director of Systems Biology at Phillip Morris International and program leader. She has a profound understanding of inhalation toxicology and computational modeling of smoking-related diseases, lung cancer, COPD, and CVD. Dr. Hoeng holds a BSc in biology, MSc in bioinformatics, PhD in protein crystallography, and an executive MBA.
David Bovard is a scientist at Philip Morris with expertise in the field of organotypic models and microfluidic systems. Before this role, David led the development of a company-owned lung/liver-on-a-chip to assess the toxicity of aerosols accurately.
Peitsch, Manuel C.
Dr. Peitsch is Chief Scientific Officer and VP of Research and Development at Philip Morris International. He has extensive experience in tobacco harm reduction, smoking-related diseases, systems biology, toxicology, bioinformatics, chemoinformatics, high-performance computing, and knowledge management. An innovation-focused results-driven biomedical research leader, Dr. Peitsch has many years of experience managing large multi-cultural teams across several countries. He holds several patents related to proteomics, genomics, and computer science and has published over 200 book chapters, technical reports, and articles in top ranking scientific journals (cited over 22000 times). He has done pioneering work in the area of molecular modeling, cell biology, computational text analytics, and systems biology/toxicology and is a founder of several initiatives, including two start-up companies, the Swiss Institute of Bioinformatics, and the [BC]2 conference (http://www.bc2.ch). He is Chairman of the Executive Board of the Swiss Institute of Bioinformatics and an active scientific advisor to several academic and commercial entities. He has also served on the Swiss National Research Council. Dr. Peitsch is a Computerworld Honors Laureate and a recipient of several awards including the New England Business and Technology Award and the United Devices Grid Visionary Award. He holds a BSc in life sciences, MSc in physical chemistry, and PhD in biochemistry. He is also Professor of Bioinformatics at the University of Basel.