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Phytochemicals as Lead Compounds for New Drug Discovery

  • ID: 4806679
  • Book
  • 378 Pages
  • Elsevier Science and Technology
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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases.

Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain.

  • Presents fundamental concepts and factors affecting choice for plant-based products
  • Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward
  • Highlights recent advances in computational-based drug discovery
  • Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

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Part I: Plants As Natural Sources Of Drugs 1. Plant Secondary Metabolites as Lead Compounds for the Production of Potent Drugs 2. Factors Affecting the Choice for Plant-based Products in Drug Discoveries 3. Advances in Computer-Aided Drug Discovery 4. FDA drug candidacy acceptance criteria and steps: Problems and way forward

Part II: Bio-functional Leads for Drug Development 5. Bioactive lead compounds and molecular targets for the treatment of heart diseases 6. Natural bioactive lead compounds effective against haematological malignancies 7. Adjunct Therapeutic Potential of Phytochemicals Against Cancer 8. Anti-diabetic lead compounds and targets for drug development 9. Anti-obesity functional leads and targets for drug development 10. Phytochemicals as therapeutic interventions in neurodegenerative diseases 11. Organosulfur phytochemicals against metabolic and neurodegenerative diseases: Benefits and risks 12. Lead compounds with the potentials for the treatment of chronic liver diseases 13. Phytocompounds and potential target sites against skin diseases 14. Phytochemicals as emerging therapeutic agents for alopecia treatment 15. Antiviral phytocompounds for drug development: A data mining studies 16. Shikimic acid as intermediary model for the production of drugs effective against influenza virus 17. Antimicrobial Lead Compounds from Marine Plants 18. Antibacterial lead compounds and targets for drug development 19. Awareness and Current Therapeutic Strategies of Malaria 20. Bioactive lead compounds and targets for the development of anti-malarial drugs 21. Bioactive lead compounds and targets for the development of anti-inflammatory drugs 22. Functional lead compounds and targets for the development of drugs for the treatment of male infertility 23. Prenylated flavonoids as a promising drug discovery candidate: A pharmacological update

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Egbuna, Chukwuebuka
Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), the Society of Quality Assurance (SQA) (USA), and the Royal Society of Chemistry (RSC) (United Kingdom). He has been engaged in a number of roles at New Divine Favor Pharmaceutical Industry Limited, Akuzor Nkpor, Anambra State, Nigeria, and Chukwuemeka Odumegwu Ojukwu University (COOU) in Nigeria. He has collaboratively worked on and published quite a number of research articles in the area of phytochemistry, nutrition, and toxicology and other related areas. Mr. Egbuna has edited a 3-volume set book of phytochemistry with Apple Academic Press (Phytochemistry, Volume 1: Fundamentals, Modern Techniques, and Applications; Phytochemistry, Volume 2: Pharmacognosy, Nanomedicine, and Contemporary Issues; and Phytochemistry, Volume 3: Marine Sources, Industrial Applications and Recent Advances). He has also co-edited another book on Phytochemistry: An in-silico and in-vitro Update with Springer Nature, Singapore. He is also working on other books with Elsevier, Springer Nature, Wiley-Blackwell, and Apple Academic Press. He is a reviewer and editorial board member of various journals, including serving as a website administrator for the Tropical Journal of Applied Natural Sciences (TJANS), a journal of the faculty of Natural Sciences, COOU. His primary research interests are in phytochemistry, nutrition and toxicology, food and medicinal chemistry, and analytical biochemistry. He obtained his BSc and MSc degrees in biochemistry at COOU and is presently a PhD fellow in Nutritional Biochemistry and Toxicology with the World Bank Africa Centre of Excellence, Centre for Public Health and Toxicological Research (PUTOR), University of Port-Harcourt, Rivers State, Nigeria.
Kumar, Shashank
Shashank Kumar, PhD, obtained his BSc, MSc, and PhD degrees in biochemistry from the University of Allahabad. He has worked as a postdoctoral fellow at the Department of Biochemistry in King George's Medical University. Dr. Kumar has about 60 published scientific papers, reviews, editorial articles, and book chapters in various national and international peer-reviewed journals and has been cited more than 1,200 times. His expertise is in the areas of free radical biology, cancer biology, characterization of plant products, xenobiotic metabolism, and microbiology. He is familiar with many biochemical techniques such as spectrophotometry, ELISA, electrophoresis, PCR, RT-PCR, flow cytometry, TLC, HPLC, LC-MS, cell culture, and microbiological techniques. He has presented his research findings at more than 25 national and international conferences and has attended about 30 workshops at many major universities and medical colleges throughout the India. Dr. Kumar is a life-time member of the Italo-Latin American Society of Ethnomedicine and the Indian Sciences Congress Association, and a member of the Asian Council of Science Editors in Dubai and Publication Integrity & Ethics in London. He has been awarded junior, senior, and research associate fellowships formulated and funded by various Indian agencies, such as the Indian Council of Medical Research, University Grants Commission, and the Council of Scientific and Industrial Research India.
Ifemeje, Jonathan C.
Dr. Jonathan Chinenye Ifemeje, PhD, is an Associate Professor (Reader) in the Department of Biochemistry, Faculty of Natural Sciences, Chukwuemeka Odumegwu Ojukwu University, Nigeria. He has published over 40 articles with international publishers and has attended series of workshops and conferences. He has also served as an external examiner for various institutions. He is the managing editor of the Tropical Journal of Applied Natural Sciences and a reviewer and an editorial board member for various reputable journals. He has worked extensively in the areas of phytochemistry, environment, and nutritional toxicology. He is a member of various institutes, including the Institute of Chartered Chemists of Nigeria, the Nigerian Society of Biochemistry and Molecular Biology, and Society of Quality Assurance. Dr. Ifemeje is presently the Director of Student Industrial Work Experience Scheme (SIWES), COOU and the Department of Biochemistry Postgraduate Coordinator, COOU. He has also served as the department and faculty staff adviser. He obtained his PhD in applied biochemistry from Nnamdi Azikiwe University, Awka, Nigeria, and his MSc degree in nutrition and toxicology from the University of Port-Harcourt, Nigeria.
Ezzat, Shahira M.
Professor Shahira M. Ezzat holds a Ph.D in pharmacognosy from the College of Pharmacy, Cairo University (CU) since 2007. She is a frequent speaker in conferences around the world, in which she won several prizes for excellent presentations. She has published over 60 articles including research articles, reviews, books, and book chapters in the field of chemistry and biological activity of natural products. She is positioned as a professor and head of Department of Pharmacognosy, College of Pharmacy, MSA University, Egypt. Her main field of research includes the isolation of bioactive plant constituents using advanced chromatographic techniques and the elucidation of their structures using different chemical and spectral methods. She has also performed work using in vitro enzymes-based assays for biological evaluation of plant extracts and the standardization of biologically active extracts using HPLC and other advanced techniques. In addition to identification of chemical constituents in plant extracts using HPLC-MS/MS and UPLC-MS/MS, Professor Ezzat currently works on the deep mechanism of anticancer activity of pure compounds in collaboration with National Cancer Institute (NCI) and searches for the effectiveness of Egyptian herbs as antiaging agents.
Kaliyaperumal, Saravanan
Dr. Saravanan Kaliyaperumal has been engaged in teaching and research for over 16 years. He obtained MSc Wildlife Biology and PhD degrees at A.V.C. College, Mayiladuthurai, and obtained his MSc, Bioinformatics degree at Annamalai University, India. He has been awarded Har Gobind Kohorana Best Scientist Award (2016-17). He has published 55 research papers and a book and has contributed chapters to four other books. He has completed one major research project and has organized one national and two international conferences, as well as three state-level workshops. He has been engaged in a number of academic roles at Nehru Memorial College, including his most recent appointment as Dean of Academic Affairs. He is a reviewer and editorial board member of various journals. He is a member of Indian Society of Systems for Science and Engineering and OISCA-International in Tokyo, Japan.
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