The genetic, molecular, and cellular mechanisms of neural development are essential for understanding evolution and disorders of neural systems. Recent advances in genetic, molecular, and cellular methods have generated a massive increase in new information, but there is a paucity of comprehensive and up-to-date syntheses, references, and historical perspectives on this important subject. The Comprehensive Developmental Neuroscience series is designed to fill this gap, offering the most thorough coverage of this field on the market today and addressing all aspects of how the nervous system and its components develop.
Patterning and Cell Type Specification in the Developing CNS and PNS provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on the formation of axons and dendrites, migration, synaptogenesis, and developmental sequences in the maturation of intrinsic and synapse-driven patterns. A better understanding of the mechanisms underlying cell migration may help us better understand when the process goes awry and lead to the development of treatments for many of these issues.
- Series offers ~180 chapters for ~3600 full color pages addressing ways in which the nervous system and its components develop
- Features leading experts in various subfields as Section Editors and article Authors
- All articles peer reviewed by Section Editors to ensure accuracy, thoroughness, and scholarship
- Volume sections include coverage of mechanisms which regulate: the formation of axons and dendrites, cell migration, synapse formation and maintenance during development, and neural activity, from cell-intrinsic maturation to early correlated patterns of activity
I: Formation of Axons and Dendrites 1. Development of Neuronal Polarity In Vivo 2. Role of the Cytoskeleton and Membrane Trafficking in Axon-Dendrite Morphogenesis 3. Axon Growth and Branching 4. Axon Guidance: Semaphorin/Neuropilin/Plexin Signaling 5. Roles of Eph-Ephrin Signaling in Axon Guidance 6. Axon Guidance: Slit-Robo Signaling 7. Nonconventional Axon Guidance Cues 8. Axon Regeneration 9. Axon Maintenance and Degeneration 10. Dendrite Development: Invertebrates 11. Dendritic Development: Vertebrates
II: Migration 12. Cell Polarity and Initiation of Migration 13. Leading Process Dynamics During Neuronal Migration 14. Nucleokinesis 15. Migration in the Cerebellum 16. Radial Migration in the Developing Cerebral Cortex 17. Radial Migration of Neurons in the Cerebral Cortex 18. Migration in the Hippocampus 19. Hindbrain Tangential Migration 20. Tangential Migration: The Forebrain 21. Transcriptional Regulation of Tangential Neuronal Migration in the Vertebrate Hindbrain 22. Postnatal Neurogenesis of the Forebrain 23. Migration of Myelin-Forming Cells in the CNS 24. Neuronal Migration and Brain Patterning 25. Neuronal Migration of Guidepost Cells 26. Neuronal Migration Disorders
III: Synaptogenesis 27. Molecular Composition of Developing Glutamatergic Synapses 28. In Vivo Imaging of Synaptogenesis 29. Genetic Analysis of Synaptogenesis 30. Activity-Regulated Genes and Synaptic Plasticity 31. New Imaging Tools to Study Synaptogenesis 32. Wnt Signaling 33. Neurotrophins and Synaptogenesis 34. Ephrins and Eph Receptors
Synaptogenesis and Synaptic Function 35. Neuroligins and Neurexins 36. Circuit Assembly in the Developing Vertebrate Retina 37. Synaptogenesis in the Adult CNS
Neocortical Plasticity 38. Synaptogenesis in the Adult CNS
Hippocampus 39. Synaptogenesis in the Adult CNS-Olfactory System 40. Synaptogenesis and Recovery from Cortical Trauma 41. Local translation in synaptogenesis 42. Cadherin Code 43. Microglia and synapse pruning 44. Astrocytes and synaptogenesis
IV: Developmental Sequences in the Maturation of Intrinsic and Synapse Driven Patterns 45. GABA: A Multifacet Device that Exerts a Crucial Role in Brain Development 46. Lessons from Zebrafish: Ion Channels Guide Neuronal Developmen 47. Regulation of AMPA-Type Glutamate Receptor Trafficking 48. Pre- and Postsynaptic Assembly and Maturation: Principal Mechanisms and Coordination 49. Cajal-Retzius and Subplate Cells: Transient Cortical Neurons and Circuits 50. Chloride Homeodynamics Underlying Pathogenic Modal Shifts of GABA Actions 51. GABAergic Signaling at Newborn Mossy Fiber-CA3 Synapses: Short- and Long-Term Activity-Dependent Plasticity Processes 52. BDNF and the Plasticity of Brain Networks During Maturation 53. Retinal Waves: Underlying Cellular Mechanisms and Theoretical Considerations 54. Multimodal GABAA Receptor Functions on Cell Development 55. Retinal Waves and their Role in Visual System Development 56. The Maturation of Firing Properties of Forebrain GABAergic Interneurons 57. Multiple Roles of CC2 in the Developing Brain 58. NKCC1 and Brain Maturation 59. Maturation of Inhibitory Synaptic Transmission in the Spinal Cord: Role of the Brain Stem and Contribution to the Development of Motor Patterns 60. Calcium Signals Regulate Neurotransmitter Phenotype 61. Compensation mechanisms
Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health.
Kwan, Kenneth Y.
Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.