RNA-based Regulation in Human Health and Disease offers an in-depth exploration of RNA mediated genome regulation at different hierarchies. Beginning with multitude of canonical and non-canonical RNA populations, especially noncoding RNA in human physiology and evolution, further sections examine the various classes of RNAs (from small to large noncoding and extracellular RNAs), functional categories of RNA regulation (RNA-binding proteins, alternative splicing, RNA editing, antisense transcripts and RNA G-quadruplexes), dynamic aspects of RNA regulation modulating physiological homeostasis (aging), role of RNA beyond humans, tools and technologies for RNA research (wet lab and computational) and future prospects for RNA-based diagnostics and therapeutics. One of the core strengths of the book includes spectrum of disease-specific chapters from experts in the field highlighting RNA-based regulation in metabolic & neurodegenerative disorders, cancer, inflammatory disease, viral and bacterial infections. We hope the book helps researchers, students and clinicians appreciate the role of RNA-based regulation in genome regulation, aiding the development of useful biomarkers for prognosis, diagnosis, and novel RNA-based therapeutics.
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CHAPTER 1 Introduction CHAPTER 2 Non-coding RNAs: ever-expanding diversity of types and functions CHAPTER 3 Functional categories of RNA regulation CHAPTER 4 The dynamic aspects of RNA regulation CHAPTER 5 RNA beyond humans CHAPTER 6 Extracellular RNA in human health and disease CHAPTER 7 RNA and malaria pathogenesis CHAPTER 8 RNA and metabolic disorders CHAPTER 9 RNA toxicity in tandem nucleotide repeats mediated neurodegenerative disorders CHAPTER 10 Regulation by non-coding RNAs in respiratory disorders CHAPTER 11 RNA in cancer CHAPTER 12 RNA and inflammatory autoimmune diseases CHAPTER 13 RNA and bacterial infection CHAPTER 14 RNA and stress CHAPTER 15 RNA and aging CHAPTER 16 Experimental toolkit to study RNA level regulation CHAPTER 17 Industry perspective CHAPTER 18 Summary and future perspectives