Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels.
- Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels
- Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences
- Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
1.1. Sprouting angiogenesis (D. Ribatti)
1.2. Non-angiogenesis-dependent tumor growth (F. Pezzella)
1.3. Intussusceptive microvascular growth (V. Djonov)
1.4. Vascular co-option (J. Holash)
1.5. Vasculogenic mimicry (A.J. Maniotis)
1.6. Post-natal vasculogenesis (D.J. Nolan)
1.7 The perivascular niche (Frank Winkler)
2. Clinical implications (A.L. Harris)
3. Therapeutic implications (R.S. Kerbel)
Domenico Ribatti was born in Andria, Italy, on December 27, 1956. He was awarded his M.D. degree on October 1981. His present position is full professor of Human Anatomy at the University of Bari Medical School, Italy. Domenico Ribatti is author 8 monographs. History of research on tumor angiogenesis, Springer, 2009. The chick embryo chorioallantoic membrane in the study of angiogenesis and metastases, Springer, 2010. Protagonists of medicine, Springer, 2010. Mast cells and tumours. From biology to clinic (in collaboration with E. Crivellato) Springer, 2011. Morphofunctional aspects of tumor microcirculation, Springer, 2012. Angiogenesis and anti-angiogenesis in hematological malignancies, Springer, 2014. Development of immunological competence, Springer, 2016. The role of microenvironment in the control of tumor angiogenesis, Springer,2016.
Francesco Pezzella is a histopathologist and is currently Professor of Tumour Pathology at Oxford. He worked in the past on the pathology of HIV (at the time HTLV III) infection and molecular alterations in lymphoma. Because of his friends pushing him into the field of cancer and blood vessels, eventually he discovered in the mid-nineties, by pure chance, the tumours growing without angiogenesis.