Reproductive Immunology: Basic Concepts, Immune Cells and Reproduction provides an introduction to reproductive immunology, focusing on the immunological aspects of specific pregnancy complications. The book includes discussions on immune cells, cytokines and chemokines, along with other topics that are central to the success of a pregnancy, from the process of implantation to parturition. The knowledge on the role of immune cells and the inflammatory process in each step of reproduction has grown exponentially in the last 10 years. Several autoimmune factors have been investigated as possible influences on reproductive success and failure.
We are just beginning to understand the complex interactions between the endocrine and immune system that support the human fetal semi-allograft, hence this first volume in the book series gives holistic insights for this understanding.
- Shows the detailed evaluation of the knowledge related to each immune cell type in the pregnant and not pregnant uterus
- Evaluates each immune cell type and its function during specific reproductive events
- Provides the biological background for understanding the clinical aspects that will be discussed in subsequent volumes in the series
1. The role of the immune system during reproduction: General concepts 2. Antigen presentation and pregnancy: biological concepts 3. The role of monocytes and Macrophages in the non-pregnant reproductive tract 4. The role of macrophages in pregnancy: from implantation to parturition. 5. Natural Killer cells and reproduction: before, during and after pregnancy 6. Dendritic Cells: antigen presentation and decidual preparation 7. B cells and the pregnant uterus: new concepts and characteristics 8. Neutrophils and their role in the protection of the endometrium 9. Regulatory T cells: master regulators for the success of pregnancy 10. Decidual cells and their role as immune modulators 11. Cytokines and Chemokines at the reproductive track: function and regulation 12. Immune regulatory role of glucocorticoids: Basic concepts 13. Foetal signals and their impact on material immune cells 14. Innate receptors at their role in immune regulation 15. MHC molecules during pregnancy: regulation and function 16. Mucosal immunity of the female and male reproductive tract 17. Immune Check Point during pregnancy, basic concepts
Professor Gil Mor, M.D., Ph.D. is Professor of Obstetrics and Gynecology and Reproductive Science at Yale University School of Medicine. Dr. Mor has focused his studies on the interaction between reproductive organs and the innate immune system. In his research, he examines topics related to the immunology of implantation, the role of apoptosis in tissue remodeling and cancer, as well as the role of inflammation in cancer formation and progression. Dr. Mor earned his Ph.D. in Immunoendocrinology from the Weizmann Institute of Science and his M.S. and M.D. from Hebrew University in Jerusalem.
He completed postgraduate training at the National Institutes of Health where he worked in the Laboratory of Immunology as a Postdoctoral Fellow. At Yale University, he serves as Director of the Reproductive Immunology Unit and the Translational Research Program, "Discovery To Cure (DTC). The Reproductive Immunology Unit has made important contributions in our understanding of the immunology of the female reproductive tract in normal and abnormal conditions. His studies on apoptosis and cancer, primarily the role of the Fas/FasL system in tissue renewal and the regulation of apoptosis in cancer cells and immune cells, have been published in prestigious journals and are highly cited.
He is member of the American Association for Cancer Research and the Society for Gynecologic Investigation and the former Treasurer of the American Society of Reproductive Immunology. He is also honorary member of several scientific societies in South America, China and Japan. Dr. Mor was elected as the Editor in Chief of the Journal of the American Society for Reproductive Immunology and is the member of the Editorial Board of numerous journals. Dr. Mor has five patents licensed to pharmaceutical companies. Dr. Mor is also founder and organizer of the DTC High School internship program; an educational program to promote science in high school students, undergraduate students, and science educators. The program is an internationally recognized educational activity, enrolling 30 students out of more than 200 applications per year. The program is supported by NIH/NCI and private foundations.