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Protein Interactions as Targets in Drug Discovery, Vol 121

  • ID: 4858510
  • Book
  • 264 Pages
  • Elsevier Science and Technology
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Protein Interactions as Targets in Drug Discovery, Volume 122 is dedicated to the design of therapeutics, both experimental and computational, that target protein interactions. Chapters in this new release include Trends in structure based drug design with protein targets, From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD), Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis, Aromatic-aromatic interactions in protein-drug and protein-protein interactions, Role of protein-protein interaction in allosteric drug design within the human methyltransferome, and much more.

  • Integrates experimental and computational methods for studying protein interactions and their modulation by potential therapeutics
  • Contains timely chapters written by well-renown authorities in their field
  • Covers information that is well supported by a number of high quality illustrations, figures and tables
  • Targets a very wide audience of specialists, researchers and students
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1. Latest trends in structure based drug design with protein targets Angshuman Bagchi 2. From fragment- to peptide-protein interaction: addressing the structural basis of binding using Supervised Molecular Dynamics (SuMD) Stefano Moro 3. Protein-protein and protein-ligand interactions: identification of potential inhibitors through computational analysis M. Michael Gromiha 4. Aromatic-aromatic interactions in protein-drug and protein-protein interactions Adrian Gustavo Turjanski 5. Role of protein-protein interaction in allosteric drug design within the human methyltransferome Guang Hu 6. Protein-Protein Interactions as the Basis for Cyclin-Dependent Kinase Inhibition Mark Klein 7. Targeting FOXP3 complex ensemble in drug discovery Bin Li 8. Targeting arrestin interactions with its partners for therapeutic purposes Vsevolod V. Gurevich 9. Protein interactomics in kidney stone research Visith Thongboonkerd 10. Human oral microbiome protein-protein interaction a cross-talk with health systemic implications Marlene M.T. Barros 11. Protein-protein complexes as targets for drug discovery against infectious diseases Yusuf Akhter 12. Therapeutic intervention of protein-protein interactions in innate immunity Kevin J. Lumb 13. Physicochemical determinants of antibody-protein interactions Sibel Kalyoncu Uzunlar
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Donev, Rossen
Rossen Donev received his PhD degree in 1999 from the Institute of Molecular Biology, Bulgarian Academy of Sciences. He did postdoctoral training at Imperial Cancer Research Fund, UK (renamed after the merger with Cancer Research Campaign to Cancer Research UK, London Research Institute) and Cardiff University. In 2007 he was awarded a New Investigator Grant Award from the Medical Research Council (UK) to establish himself as an independent Principle Investigator. In 2010 Dr. Donev was appointed Senior Lecturer at Swansea University. In 2016 Dr. Donev joined MicroPharm Ltd (UK) where currently he is Head of Research. He has published more than 60 research papers, chaired scientific meetings and given invited plenary talks. Rossen Donev has consulted on projects related to development of treatments for neurodevelopmental disorders and cancer therapies. He serves as Editor-in-Chief of the Advances in Protein Chemistry and Structural Biology and on editorial board of several other journals. His research interests include signaling pathways involved in neuropsychiatric disorders and tumor escape from the immune system, and development of therapeutic strategies for their treatment. More recently he has focused on design of antibody-based oral treatment of pathological conditions of the gastrointestinal tract.
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