Patterning and Cell Type Specification in the Developing CNS and PNS, Second Edition, the latest release in the Comprehensive Developmental Neuroscience series, presents recent advances in genetic, molecular and cellular methods that have generated a massive increase in new information. The book provides a much-needed update to underscore the latest research in this rapidly evolving field, with new section editors discussing the technological advances that are enabling the pursuit of new research on brain development. This volume focuses on neural patterning and cell type specification in the developing central and peripheral nervous systems.
- Features leading experts in various subfields as section editors and article authors
- Contains articles that are peer reviewed to ensure accuracy, thoroughness and scholarship
- Covers mechanisms which control regional specification, regulate proliferation of neuronal progenitors, control differentiation and survival of specific neuronal subtypes, and control the development of non-neural cells
I: Induction and Patterning of the CNS and PNS 1. Telencephalon Patterning 2. Morphogens, Patterning Centers, and their Mechanisms of Action 3. Midbrain Patterning: Isthmus Organizer, Tectum Regionalization, and Polarity Formation 4. Area Patterning of the Mammalian Cortex 5. The Formation and Maturation of Neuromuscular Junctions 6. Neural Induction of Embryonic Stem/Induced Pluripotent Stem Cells 7. Spinal Cord Patterning 8. Patterning of the Diencephalon 9. Neural Induction Embryonic Stem Cells 10. Plan of the Developing Vertebrate Nervous System: Relating Embryology to the Adult Nervous System (Prosomere Model, Overview of Brain Organization) 11. Cerebellar Patterning 12. Hox Genes and Neural Patterning in Drosophila 13. Induction and Patterning of Neural Crest and Ectodermal Placodes and their Derivatives 14. Cerebral organoids 15. Olfactory epithelium 16. Patterning of reptilian forebrain 17. Fish patterning 18. Formation of gyri and sulci
II: Generation of Neuronal Diversity 19. Cell Biology of Neuronal Progenitor Cells 20. Cell Cycle Regulation in Brain Construction 21. Regulation of Neuronal Survival by Neurotrophins in the Developing Peripheral Nervous System 22. Notch and Neural Development 23. bHLH Factors in Neurogenesis and Neuronal Subtype Specification 24. Environmental Cues and Signaling Pathways that Regulate Neural Precursor Development 25. Specification of Neural Crest- and Placode-Derived Neurons 26. The Specification and Generation of Neurons in the Ventral Spinal Cord 27. Neurogenesis in the Cerebellum 28. The Generation of Midbrain Dopaminergic Neurons 29. Neurogenesis in the Basal Ganglia 30. Specification of Cortical Projection Neurons: Transcriptional Mechanisms 31. The Generation of Cortical Interneurons 32. Specification of Retinal Cell Types 33. Neurogenesis in the Postnatal VZ-SVZ and the Origin of Interneuron Diversity 34. Neurogenesis in the Damaged Mammalian Brain 35. Neurogenesis in the Nematode Caenorhabditis elegans 36. Development of the Drosophila Embryonic Ventral Nerve Cord: From Neuroectoderm to Unique Neurons and Glia 37. Neurogenesis in Zebrafish 38. Epigenetic/enhancer regulation of neural diversity 39. Single cell sequencing and neuronal diversity 40. Sequential generation 41. Post-transcriptional regulation of corticogenesis
III: Development of Glia, Blood Vessels, Choroid Plexus, Immune Cells in the Nervous System 42. 'Glial' Biology: Has it Come to the Beginning of the End? 43. Neural Stem Cells Among Glia 44. Structure and Function of Myelinated Axons 45. Mechanisms of Astrocyte Development 46. Specification of Macroglia by Transcription Factors: Oligodendrocytes 47. Specification of Macroglia by Transcription Factors: Schwann Cells 48. Signaling Pathways that Regulate Glial Development and Early Migration 49. Signaling Pathways that Regulate Glial Development and Early Migration 50. Microglia 51. Ependyma, Choroid 52. Meninges and Vasculature 53. Neuron-Glial Interactions: Schwann Cells 54. Neuron-Glial Interactions: Neurotransmitter Signaling to Cells of the Oligodendrocyte Lineage 55. Invertebrate Glia 56. Nonmammalian Model Systems: Zebrafish 57. New Approaches in Glial Biology: Imaging Neuroglial Pathology In Vivo
Dr. Chen is Professor of Molecular, Cell, and Developmental Biology at the University of California, Santa Cruz. Research in her laboratory focuses on the cellular and molecular mechanisms that underlie the generation of diverse cell types in the brain, and the assembly of these cell types into functional neural circuits. Dr. Chen completed her graduate study with Dr. Sidney Strickland at Stony Brook University-SUNY, and her post-doctoral training in the laboratory of Dr. Susan McConnell at Stanford University. She has 22 years of experience in genetics and developmental neurobiology research. Her laboratory has been funded by the March of Dimes Foundation, California Institute of Regenerative Medicine, and National Institute of Health.
Kwan, Kenneth Y.
Dr. Kwan is Assistant Professor of Human Genetics and Research Assistant Professor in the Molecular and Behavioral Neuroscience Institute at the University of Michigan Medical School. Research in his laboratory is aimed at the molecular and cellular mechanisms that underlie normal neural circuit assembly in the cerebral cortex and their dysregulation in human neurodevelopmental disorders, in particular autism spectrum disorder, fragile X syndrome, and schizophrenia. Dr. Kwan completed his graduate and post-doctoral training in the laboratory of Dr. Nenad Sestan at Yale School of Medicine. He has 14 years of experience in developmental neurobiology research and his worked has been recognized by awards from the Brain Research Foundation, March of Dimes Foundation, Simons Foundation, and Cajal Club.