Breathborne Biomarkers and the Human Volatilome, Second Edition, provides a much-needed update to the classic 2013 edition of the book. The new editing team has expanded this edition beyond volatile organic compounds to cover the whole field of breath analysis, including the many exciting developments that have occurred since the first edition published. Breathborne biomarkers carry much information on the state of human health, and their role in clinical diagnosis and therapeutic monitoring has become increasingly significant due to advances in the field. This thoroughly revised volume includes the latest discoveries and applications in breath analysis from the world's foremost scientists.
- Covers the latest research and includes new material on novel mass spectrometry methods for breath analysis, novel sensors and instrumentation, and novel data analytics for untargeted and targeted breath biomarker detection
- Appeals to a multidisciplinary audience, including scientists, researchers and clinicians with an interest in breath analysis
- Includes case presentations documenting applications in multiple areas of human health and safety
PART A: Physiological Basis of Biomarkers 1. The Human Volatilome 2. Physiological Modeling of Exhaled Breath 3. Sampling
PART B: Nitric Oxide and Carbon Monoxide 4. Nitric Oxide: Physiology and Modeling 5. Nitric Oxide: Clinical Applicaitons 6. Carbon Monoxide in Pulmonary Diseases
PART C: Analytical Platforms and Sensors 7. Selected Ion Flow Tube Mass Spectrometry 8. Proton Transfer Reaction Mass Spectrometry 9. Ion Mobility Spectrometry 10. Secondary Electrospray Ionization 11. Sensor Systems 12. Optical Spectroscopy 13. Comprehensive Gas Chromatography-Mass Spectrometry 14. High-Resolution Mass Spectrometry
PART D: Clinical Breath Tests 15. Isotope Labelled Substrates 16. Good Study Design, Blinded Validation, and Clinical Cohort Selection 17. Lifestyle Applications 18. Cancer Biomarkers in Exhaled Breath 19. Breath Analysis in Critically Ill Patients
PART E: Exhaled Breath Condensate (EBC) and Aerosol Particulates 20. Introduction to the Non-VOC fraction of Breath 21. Particles in Exhaled Air 22. Chronic Obstructive Pulmonary Disease and Smokers 23. Exhaled Breath Aerosols
PART F: Volatiles of Microbial Origin: Urine, Stool and in vitro Cultures 24. Urine and Stool 25. Host Response to Infection for Respiratory Viruses 26. Volatile Biomarkers of Malaria Infection 27. Bacterial Infections 28. VOCs from Cell Cultures 29. Skin VOCs
PART G: Animal Models and Veterinary Applications 30. Ruminants 31. Marine Mammals 32. Mammal Models
PART H: Security Applications 33. Urban Search and Rescue 34. Exposome 35. Mass Casualty Triage 36. Breath Analysis in Occupational Medicine 37. Canine olfaction 38. Breath Ethanol for Law Enfocement 39. Drugs in breath
PART I: Interpretation of Breath Analysis Data
40. Challenges in Clinical Breath Research Development 41. Mathematical and Statistical Approaches 42. Data Analysis, Signal Processing and Classification 43. Bioinformatics and Analytical Workflow Management 44. Clinical Phenotyping 45. Human Exposure Studies
Professor Cristina Davis is Vice Chair and Professor of Mechanical and Aerospace Engineering at the University of California Davis, United States. Her research work focuses on development of novel chemical and biological sensor systems, and biomarker identification for high priority application areas in agriculture and human/animal health monitoring. She is a 2016 Fellow of the American Institute for Medical and Biological Engineering (AIMBE) and a 2011 Fellow of The Hartwell Foundation. She has 10 issued patents and has co-authored more than 100 peer-reviewed journal articles and book chapters. She earned her BS in mathematics and biology from Duke University and her Ph.D. in biomedical engineering from the University of Virginia, and she completed a postdoctoral fellowship in electrical engineering and physiology at the Johns Hopkins University. Having spent more than a half-decade working in industry, she joined the University of California Davis as an academic professor in late 2005.
Jonathan Beauchamp holds an M.S. degree in Physics (University College London, UK) and Ph.D. in Environmental Physics (University of Innsbruck, Austria). He currently works as a research associate at the Fraunhofer Institute for Process Engineering and Packaging IVV in Freising, Germany, where he manages an applied research group that investigates the emissions of volatile organic compounds (VOCs) from diverse sources, including the human volatilome. Jonathan has been involved in breath research for the past 15 years and is currently principal investigator in several breath-related projects. He is an active member (and current treasurer) of the International Association of Breath Research (IABR), for which he co-chairs the focus group on standardization, and is also Associate Editor of Journal of Breath Research.
Joachim Pleil holds B.S. degrees in Mathematics and Physics, M.S. in Physics (SIU, Carbondale, IL), and Ph.D. in Environmental Science and Engineering (UNC, Chapel Hill, NC). In 1980, he joined Northrop Corp. as a Physicist designing laser-based optical instrumentation and then moved to U.S. EPA in 1987 as a Research Scientist developing analytical methods for measuring organic environmental pollutants. He has published over 150 journal articles, many involving breath biomarker research and statistical interpretation of breath-based data. He serves as Professor (adjunct) at the University of North Carolina School of Public Health where he teaches Environmental Exposure Assessment. He is currently assigned to a U.S. NASA team to assist on their Pilot Breathing Assessment project. He is a founding member of International Association of Breath Research (IABR) and Institute of Physics Journal of Breath Research (JBR); he has been serving as Editor-in-Chief of JBR since 2014.