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Issues in Calibrations and Accuracy in Method Validation - Webinar

  • ID: 4899881
  • Webinar
  • February 2019
  • Region: Global
  • 90 Minutes
  • Compliance Online
Why Should You Attend:

Accuracy, the ability for a methodology to give results within acceptable limits when compared to known values, is a fundamental and key requirement. Calibration is the most common approach to obtain accuracy.

Accuracy requires a comparison to a validated material. The level of confidence depends on traceability, a chain connecting the samples of interest all the way to the specific metric standards. This can be a complex task which can raise doubts in an auditor. There are different situations for the use of each of standards of the various types. How to access the validity is a key.

In calibration, fundamental reliance on linearity of response make proof of linearity important. This is more involved that only obtaining a linear regression factor or correlation coefficient. Once proven, though, calibrations can change with various factors. Monitoring calibration behavior and using that to maintain or even improve a methodology can be very useful.

Areas Covered in the Webinar:

How accuracy is determined
What are the various types of standards and what are their strengths and weaknesses?
The importance of traceability
Calibration curves – what are the important criteria? Linearity versus nonlinearity, slope, intercept and what they mean
Matrix effects and how to deal with them
Using calibration data to monitor performance
Note: Product cover images may vary from those shown
John C. Fetzer, has had over 30 year experience in HPLC methods development. He has authored or co-authored over 50 peer-reviewed papers on liquid chromatography, has served on the editorial advisory boards of the Journal of Chromatography, Analytical Chemistry, and Analytical and Bio analytical Chemistry.
Note: Product cover images may vary from those shown