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Issues in Calibrations and Accuracy in Method Validation - Webinar (Recorded)

  • Webinar

  • 90 Minutes
  • February 2019
  • Compliance Online
  • ID: 4899881
Why Should You Attend:

Accuracy, the ability for a methodology to give results within acceptable limits when compared to known values, is a fundamental and key requirement. Calibration is the most common approach to obtain accuracy.

Accuracy requires a comparison to a validated material. The level of confidence depends on traceability, a chain connecting the samples of interest all the way to the specific metric standards. This can be a complex task which can raise doubts in an auditor. There are different situations for the use of each of standards of the various types. How to access the validity is a key.

In calibration, fundamental reliance on linearity of response make proof of linearity important. This is more involved that only obtaining a linear regression factor or correlation coefficient. Once proven, though, calibrations can change with various factors. Monitoring calibration behavior and using that to maintain or even improve a methodology can be very useful.

Areas Covered in the Webinar:

How accuracy is determined
What are the various types of standards and what are their strengths and weaknesses?
The importance of traceability
Calibration curves – what are the important criteria? Linearity versus nonlinearity, slope, intercept and what they mean
Matrix effects and how to deal with them
Using calibration data to monitor performance

Speakers

John C. Fetzer, has had over 30 year experience in HPLC methods development. He has authored or co-authored over 50 peer-reviewed papers on liquid chromatography, has served on the editorial advisory boards of the Journal of Chromatography, Analytical Chemistry, and Analytical and Bio analytical Chemistry.