Histone Modifications in Therapy provides an in-depth analysis of the role of histone mechanisms in major diseases and the promise of targeting histone modifications for disease prevention and treatment. Here, researchers, clinicians and students will discover a thorough, evidence-based discussion of the biology of histones, the diseases engaged by aberrant histone modifications, and pathways with therapeutic potential. Expert chapter addresses the role of histone modifications across a variety of disorders, including cancer, neuropsychiatric, neurodegenerative, cardiac, metabolic, infectious, bacterial, autoimmune and inflammatory disorders, among others. In relation to these disease types, histone modifications are discussed, both as mechanisms of prevention and possible treatment.
A concluding chapter brings together future perspectives for targeting histone modifications in therapy and next steps in research.
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1. Histone modifications in diseases
Section I Targeting histone modifications for cancer treatment 2. HDAC inhibitors in cancer therapy 3. HAT inhibitors in cancer therapy 4. Targeting DOT1L for mixed-lineage rearranged leukemia 5. BET mechanisms in cancer 6. Histone demethylase inhibitors and their potential in cancer treatment 7. Targeting chromatin remodelers in urological tumors
Section II Targeting histone modifications for infectious disease 8. The therapeutic potential of epigenetic manipulation during infectious diseases 9. Targeting histone deacetylases for bacterial infections 10. Targeting histone epigenetics to control viral infections
Section III Targeting histone modifications for treating other pathologies 11. Targeting histone modifications in psychotic disorders 12. Epigenetic treatment of neurodegenerative diseases 13. Histone modification as a potential preventative and therapeutic approach for cardiovascular disease 14. The potentiality of histone deacetylase inhibitors for diabetes and obesity 15. Targeting histone modifications in cancer immunotherapy 16. Epigenetic drug development for autoimmune and inflammatory diseases 17. Future perspectives for targeting histone modifications in therapy