Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms.
Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics.
- Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations
- Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers
- Features chapter contributions from international researchers in the field
Section I: Spermatogenesis, Oogenesis and fertility 1. Epigenetic reprograming and maintenance in the male and female germline 2. Genomic Imprinting 3. Chromatin remodelling of the male genome during spermiogenesis and embryo development 4. Stem cells and epigenetics 5. Aberrant epigenetics and reproductive disorders (PCOS, Endometriosis, male infertility etc)
Section II: Pregnancy/developmental/placental epigenetics 6. Epigenetic reprogramming of the embryo 7. Epigenetic modulation during placentation 8. Epigenetic modulation during pregnancy and pregnancy related disorders 9. Fetal origin of adult onset diseases
Section III: Epigenetic
Lifestyle, Aging and Environmental Influence 10. Environmental chemicals and Endocrine disruptors 11. Nutrition 12. Stress and Lifestyle 13. Aging of male and female gametes/Reproductive senescence
Section IV: Reproductive cancer and epigenetics 14. Testicular and Prostrate cancers 15. Breast cancers 16. Ovarian and Endometrial cancers 17. Cervical cancers
Section V: Epigenetics in diagnosis, prognosis and therapy 18. Natural products / synthetic molecule as an epigenetic modifier 19. Epigenetic markers in prognosis / early diagnosis 20. Therapies targeting the epigenome