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Lipid Signaling and Metabolism

  • Book

  • August 2020
  • Elsevier Science and Technology
  • ID: 4991095

Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics.

Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine.

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Table of Contents

1. Homeostatic Control of Membrane Lipid Biosynthesis in Bacteria 2. Lipid trafficking and signaling in plants 3. Sex as a modulator of lipid metabolism and metabolic disease 4. Local interactions in the bone marrow microenvironment and their contribution to system metabolic processes 5. Lipids in the Transcriptional Regulation of Adipocyte Differentiation and Metabolism 6. Lipid receptors and signaling in adipose tissue 7. Adipocyte lipolysis and lipid derived metabolite signaling 8. Regulation of Intracellular Lipid Storage and Utilization 9. The lipid droplet as a signaling node 10. Lipid droplets in the immune response and beyond 11. Fatty acids mediators and the inflammasome 12. Identification and pathophysiological roles of LTB4 receptors BLT1 and BLT2 13. The Forkhead Box O family in Insulin Action and Lipid Metabolism 14. Interplays between nutritional and inflammatory signaling and fat metabolism in pathophysiology of NAFLD 15. Endocannabinoids: The Lipid Effectors of Metabolic Regulation in Health and Disease 16. Gut Microbiota Interaction in Host Lipid Metabolism 17. Insights into the metabolism of lipids in Obesity and Diabetes 18. Lipid metabolic features of skeletal muscle in pathological and physiological conditions 19. Sphingolipid mediators of cell signaling and metabolism 20. Role of bile acid receptors in the regulation of cardiovascular diseases 21. Molecular Mechanisms Underlying Effects of n-3 and n-6 Fatty Acids in Cardiovascular Diseases 22. Lipid metabolism and signaling in Cancer 23. Altered lipid metabolic homeostasis in Alzheimer's disease 24. Role of Xenosterols in Health and Disease 25. Adipose Tissue Development and Metabolic Regulation


James M. Ntambi Professor of Biochemistry, Steenbock Professor of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI, USA. Dr. James M. Ntambi is Professor of Biochemistry and the Steenbock Professor of Nutritional Sciences, at the University of Wisconsin-Madison, as well as Adjunct Professor of Biological Chemistry at Johns Hopkins University School of Medicine. The focus of Dr. Ntambi's research is to understand the genetic regulation of metabolism, adipocyte biology, and differentiation. He is specifically interested in the genetic basis of obesity, cardiovascular disease, insulin resistance, diabetes and fatty live disease and how dietary factors, hormones, and environmental factors influence these disease states. Most recently, his team have genetically engineered mice that are born without the stearoyl-CoA desaturase gene-1, and found that these mice resist obesity, diabetes, and fatty liver disease. Dr. Ntambi also conducts research on obesity and diabetes and other non-communicable metabolic diseases in developing countries. He has set up the Lweza-Mukono Community Health Initiatives Inc. (lwezahealth.org) a registered organization operating as a center of excellence in Lweza village Mukono District, Uganda implementing projects linking health to agriculture, nutrition and education to address, prevent, delay and manage the non-communicable metabolic diseases referred to above. Dr. Ntambi has published more than 200 scientific articles in such journals as Cell Metabolism, JBC, Journal of Lipid research, PNAS, JCI, Scientific Reports, PLoS ONE, BBRC, Gastroenterology, and Journal of Hepatology.