Lipid Signaling and Metabolism provides foundational knowledge and methods to examine lipid metabolism and bioactive lipid signaling mediators that regulate a broad spectrum of biological processes and disease states. Here, world-renowned investigators offer a basic examination of general lipid, metabolism, intracellular lipid storage and utilization that is followed by an in-depth discussion of lipid signaling and metabolism across disease areas, including obesity, diabetes, fatty liver disease, inflammation, cancer, cardiovascular disease and mood-related disorders. Throughout, authors demonstrate how expanding our understanding of lipid mediators in metabolism and signaling enables opportunities for novel therapeutics.
Emphasis is placed on bioactive lipid metabolism and research that has been impacted by new technologies and their new potential to transform precision medicine.
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Table of Contents
1. Homeostatic Control of Membrane Lipid Biosynthesis in Bacteria 2. Lipid trafficking and signaling in plants 3. Sex as a modulator of lipid metabolism and metabolic disease 4. Local interactions in the bone marrow microenvironment and their contribution to system metabolic processes 5. Lipids in the Transcriptional Regulation of Adipocyte Differentiation and Metabolism 6. Lipid receptors and signaling in adipose tissue 7. Adipocyte lipolysis and lipid derived metabolite signaling 8. Regulation of Intracellular Lipid Storage and Utilization 9. The lipid droplet as a signaling node 10. Lipid droplets in the immune response and beyond 11. Fatty acids mediators and the inflammasome 12. Identification and pathophysiological roles of LTB4 receptors BLT1 and BLT2 13. The Forkhead Box O family in Insulin Action and Lipid Metabolism 14. Interplays between nutritional and inflammatory signaling and fat metabolism in pathophysiology of NAFLD 15. Endocannabinoids: The Lipid Effectors of Metabolic Regulation in Health and Disease 16. Gut Microbiota Interaction in Host Lipid Metabolism 17. Insights into the metabolism of lipids in Obesity and Diabetes 18. Lipid metabolic features of skeletal muscle in pathological and physiological conditions 19. Sphingolipid mediators of cell signaling and metabolism 20. Role of bile acid receptors in the regulation of cardiovascular diseases 21. Molecular Mechanisms Underlying Effects of n-3 and n-6 Fatty Acids in Cardiovascular Diseases 22. Lipid metabolism and signaling in Cancer 23. Altered lipid metabolic homeostasis in Alzheimer's disease 24. Role of Xenosterols in Health and Disease 25. Adipose Tissue Development and Metabolic Regulation