Microbiota-Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.
- Reviews the many approaches to manipulating the microbiota in animal studies - including the use of germ-free animals, antibiotics and diet - and covers the strengths and limitations of each
- Outlines available microbiota research tools, such as 16S sequencing and shot-gun metagenomics
- Provides a comprehensive guide to analyzing microbiota-related data and the many choices for bioinformatics
1. Gut-brain Axis 2. Research approaches to manipulate/study microbiota 3. Microbiota analysis tools and techniques 4. What is a healthy microbiome? 5. Gene-environment contributions to microbiota composition, diversity, and function 6. Microbiota-brain communication in neurodevelopment
the first 1000 days 7. Microbiota in neurodevelopmental disorders 8. Microbiota-brain interactions in mental health
adolescence and adult 9. Microbiota-brain interactions in neurodegeneration 10. Antibiotics 11. Probiotics 12. Fecal transplantation 13. Microbiota-related biomarkers for precision medicine and drug discovery 14. Future considerations
Dr. Jane Foster is an Associate Professor in the Department of Psychiatry and Behavioural Neurosciences at McMaster University in Hamilton, ON. She holds a research appointment as a Scientific Associate with the University Health Network and as a Scientist at St. Michael's Hospital in Toronto, ON. Dr. Foster is an active researcher in two large translational networks ¬the Province of Ontario Neurodevelopmental Disorders Network (POND) and the Canadian Biomarkers in Depression (CAN-BIND). Dr. Foster's research focuses on the role of immune-brain and gut-brain interactions on neurodevelopment, behaviour, and brain function. Dr. Foster hopes that her research accomplishments lead to a better understanding of how these relationships contribute to psychiatric disorders such as neurodevelopmental disorders, anxiety and depression.
Diaz Heijtz, Rochellys
Dr. Rochellys Diaz Heijtz is an Associate Professor of Translational Neuroscience at the Department of Neuroscience, Karolinska Institutet, Sweden. Her research studies have a long-term goal of understanding the biological basis of neurodevelopmental disorders (ASD, ADHD), and how genes and the environment (prenatal and/or early postnatal) together influence brain development and behavior. Her research program includes basic studies investigating the impact of the gut microbiota on the development of neuronal circuitries that control emotional, motor and social behavior. Furthermore, ongoing clinical studies are investigating the potential role of the gut microbiota in the pathophysiology of ASD and other neurodevelopmental disorders.