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Microbiota Brain Axis. A Neuroscience Primer

  • Book
  • 496 Pages
  • October 2022
  • Elsevier Science and Technology
  • ID: 5007870
Microbiota Brain Axis: A Neuroscience Primer provides neuroscience researchers with a comprehensive guide on how to conduct effective microbiota-brain research, understand the appropriate methodologies, and collect and analyze microbiota data. The book begins with an introduction to the importance of the microbiota-brain communication in development and how microbiota impact neurodevelopmental disorders, mental health and neurodegeneration. In addition, the book discusses advances in microbiota analysis tools and techniques for neuroscience related research.

Table of Contents

1. Gut-brain Axis
2. Research approaches to manipulate/study microbiota
3. Microbiota analysis tools and techniques
4. What is a healthy microbiome?
5. Gene-environment contributions to microbiota composition, diversity, and function
6. Microbiota-brain communication in neurodevelopment the first 1000 days
7. Microbiota in neurodevelopmental disorders
8. Microbiota-brain interactions in mental health adolescence and adult
9. Microbiota-brain interactions in neurodegeneration
10. Antibiotics
11. Probiotics
12. Fecal transplantation
13. Microbiota-related biomarkers for precision medicine and drug discovery
14. Future considerations


Jane A. Foster Professor, Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada. Dr. Jane Foster is a Professor in the Department of Psychiatry and Behavioural Neurosciences at McMaster University in Hamilton, ON, a Scientific Associate at University Health Network and a Scientist at St. Michael's Hospital in Toronto, ON. Dr. Foster is an active researcher in the Province of Ontario Neurodevelopmental Disorders Network (POND) and the Canadian Biomarker Integration Network in Depression in Depression (CAN-BIND). The Foster lab research team focuses on the role of microbiota-immune-brain interacations on neurodevelopment, behaviour, and brain function and aims to understand how these relationships contribute to psychiatric disorders such as neurodevelopmental disorders, anxiety and depression. Gerard Clarke Lecturer, Department of Psychiatry and Neurobehavioural Science and Principal Investigator, APC Microbiome Ireland, University College Cork, Cork, Ireland. Dr Gerard Clarke is a Lecturer in the Department of Psychiatry and Neurobehavioural Science and a Principal Investigator in APC Microbiome Ireland at University College Cork. His research interests include translational biomarkers of stress-related neuropsychiatric disorders, the impact of the gut microbiome on brain and behaviour across the life span and microbial regulation of tryptophan metabolism. Target human populations of his research include those with major depression and anxiety as well as gastrointestinal disorders with high psychiatric comorbidities such as irritable bowel syndrome.