Fungi are both the cause of many major health problems and an incredible source of compounds for developing new medicinal treatments, and with the increasing emergence of multidrug resistance, the need for new antimicrobial agents is greater than ever. Antifungal Compound Discovery provides researchers with a detailed study of both natural and synthetic compounds that can be effective against a variety of fungal species, supporting and encouraging the design of innovative, potent new drug candidates for the treatment of fungal infections.
Beginning with an introduction to both the history and latest developments in this field, the book goes on to provide helpful background information on key fungal species before outlining current antifungal therapies and reasons further development is needed. Detailed chapters then follow reviewing a broad range of natural and synthetic antifungal agents, and discussing the synergistic effect of working with both simultaneously. Finally, the book concludes by considering potential future developments in this important field.
Supported with detailed schemes and key information on the biological activity of all selected compounds, Antifungal Compound Discovery is a comprehensive guide helping researchers understand the relationship between specific chemicals structures and their antifungal potency, and a key tool for all those involved in the identification and development of antimicrobial compounds.
- Provides an overview of the most specific mycotic infections and fungal species as background for compound development
- Presents the chemical formulas of all natural and synthetic compounds reviewed
- Combines detailed information about origin, isolation and possible therapeutic uses of all indexed compounds, including biological activity, mechanism of action and SAR information
2. Fungal infections
Background to specific fungal species
3. Antifungal therapy
4. Natural products as antifungals
5. Synthetic antifungal compounds
6. Future trends
7. Concluding remarks
Dr. Sokovic is a pioneer in the study of antibacterial and antifungal activity of metabolites of plants, fungi, and their extracts. In addition to her extensive experience as a teacher, researcher, and consultant, she has led a number of international projects, published over 250 papers and 5 book chapters with international publishers, and participated in over 120 conferences. Additionally, she is a reviewer for a number of prominent journals.
Dr. Sokovic's main research interests are in the fields of mycology and chemistry of natural products, activity of secondary metabolites of medicinal plants and fungi, and pathogenic fungi.
Konstantinos Liaras is a Doctor of Medicinal Chemistry at the department of Pharmacy at Aristotle University of Thessaloniki, Greece. He is a community pharmacist, an elected national delegate of the Panhellenic Pharmaceutical Association of Greece, and also a council member of the Pharmaceutical Association of Kilkis, Greece. Moreover, Dr. Liaras is a compounder and has experience in teaching Medicinal Chemistry and Pharmacology.
Dr Liaras's research interests include the design, synthesis, purification, structural determination, and identification of novel synthetic heterocyclic compounds; evaluation of anti-inflammatory, antibacterial, antifungal, and antioxidant activity of synthesized molecules; and the study of SAR of biologically active compounds.