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Dancing Protein Clouds: Intrinsically Disordered Proteins in Health and Disease, Part B, Vol 174. Progress in Molecular Biology and Translational Science

  • ID: 5007980
  • Book
  • September 2020
  • Region: Global
  • 300 Pages
  • Elsevier Science and Technology
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"Dancing protein clouds: Intrinsically disordered proteins in the norm and pathology" represents a set of selected studies on a variety of research topics related to intrinsically disordered proteins. Topics in this update include structural and functional characterization of several important intrinsically disordered proteins, such as 14-3-3 proteins and their partners, as well as proteins from muscle sarcomere; representation of intrinsic disorder-related concept of protein structure-function continuum; discussion of the role of intrinsic disorder in phenotypic switching; consideration of the role of intrinsically disordered proteins in the pathogenesis of neurodegenerative diseases and cancer; discussion of the roles of intrinsic disorder in functional amyloids; demonstration of the usefulness of the analysis of translational diffusion of unfolded and intrinsically disordered proteins; consideration of various computational tools for evaluation of functions of intrinsically disordered regions; and discussion of the role of shear stress in the amyloid formation of intrinsically disordered regions in the brain.

  • Provides some recent studies on the intrinsically disordered proteins and their functions, as well as on the involvement of intrinsically disordered proteins in pthogenesis of various diseases
  • Contains numerous illustrative materials (color figures, diagrams, and tables) to help the readers to delve in the information provided
  • Includes contributions from recognized experts in the field
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1. Intrinsically disordered proteins of viruses: involvement in the mechanism of cell regulation and pathogenesis Chayan K. Nandi and Pushpendra Mani Mishra 2. Using molecular simulations to study IDPs Paul Robustelli 3. Fluctuation, allostery, and binding in a mode analysis of protein dynamics Marina Guenza 4. The Balance between Liquid-Liquid Phase Separation and Fibrillization in Neurodegenerative Diseases Benjamin Wolozin 5. Intrinsic disorder and Hox transcription factor function Sarah Bondos 6. The many faces of IDPs, from protocells to modern cells Ashok Deniz 7. Dancing while self-eating: Protein intrinsic disorder in autophagy Hana Popelka 8. Intrinsic disorder in the nickel-dependent urease network Barbara Zambelli
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