Unraveling the Complexities of Metastasis: Transition from a Segmented View to a Conceptual Continuum provides a critical overview of the recent developments of metastasis research and how progress can be further enhanced in the field. Metastasis is a highly complicated mechanism and prognostic analysis of different metastatic patterns in advanced cancer patients is becoming increasingly problematic. It is therefore essential to take a step back and focus on the underlying mechanisms of metastasis before moving ahead for effective translation of laboratory findings to clinically effective therapeutics. This book is surely helpful in putting together missing pieces of an incomplete jig-saw puzzle of molecular cancer.
The book discusses topics such as the role of TRAIL-mediated signaling, late metastasis and mechanisms underlying tumor cell dormancy, CTCs and exomes, non-coding way of metastasis, and stem cells. Additionally, it brings relevant and updated information on nanotechnology-based docetaxel and the peculiarities of cancer cell metabolism.
This book is a valuable source for cancer researchers, medical doctors and several members of biomedical field who need to understand better the complex mechanism of metastasis.
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Table of Contents
1. Role of TRAIL-mediated signaling as Jekyll and Hyde in metastasis: Changing places, changing faces Ammad Ahmad Farooqi, Iqra Mobeen, Rukset Attar, and Gamze Tanriover2. Multiple roles of CTCs and exosomes in cancer metastasis, detailing the most advanced diagnostic technologies and the most innovative therapeutic approaches in preventing their spreadingChiara Martinelli3. Diagnosis and treatment of metastatic prostate cancer: The role of imaging, liquid biopsies and biomarkers for deciphering tumor heterogeneityWensi Tao4. Prognostic and predictive role of bone metastasis in NSCLC: Risk factor and clinical implications Rossana Berardi5. Brain metastasis from breast cancerMaria Luisa Gasparri, Rosa Di Micco, Arianna Siconolfi, Ammad Ahmad Farooqi, Gabrielle Di Bartolomeo, Veronica Zuber, Donatella Caserta, Filippo Bellati, Ilary Ruscito, Andrea Papadia, and Oreste D. Gentilini6. Non-coding way of the metastasis Cigir Avci7. Newer horizons with nanotechnology-based docetaxel: Upcoming avenue for management of breast tumour and its metastasisIndu Pal Kaur8. Metastasis in gynecological cancersViolante Di Donato9. Regulation of HSP90 by non-coding RNAs in carcinogenesis and metastasis: Harbingers of good or evil Seher Yilmaz, Rukset Attar, Lazzat Karasholakova, Ishmuratova Margarita Yulaevna, and Ammad Ahmad Farooqi10. Role of circular RNAs in carcinogenesis and metastasis: Closer analysis of unresolved mysteries Humaira Naureen, Rukset Attar, Ilhan Yaylim, Lara Youssef, and Ammad Ahmad Farooqi11. Metastatic potential: Focus on lipid transport with emphasis on CD36Laura C. Ceafalan12. Developmental genes: The bridge between development and cancer metastasisTania Spohr13. Heat shock proteins in tumor progression and metastasis Yusuf Tutar, Humaira Naureen, and Ammad Ahmad Farooqi14. Role of Kisspeptin-mediated signaling pathway in carcinogenesis and metastasis: Opposite sides of the same coinHumaira Naureen, Seda Avnioglu, Seher Yilmaz, Lara Youssef, and Ammad Ahmad Farooqi15. Tumor microenvironment manipulation and cancer metastasisWaleed Arafat16. Metastasis inhibitory role of Hydroxycinnamic acid and its derivativesMuhammad Javed Iqbal, Maham Fakhar, Tahira Alyas, and Ammad Ahmad Farooqi17. Regulatory role of SMURF1 and SMURF2 in Metastasis: Multitalented SMURFs occupy the StageIlhan Yaylim, Rukset Attar, Naila Nasir Mahmood, and Ammad Ahmad Farooqi18. Anti-metastatic Effects of Curcumin Durr-e-shahwar Malik, Tatiana Colombo Pimentel, Naila Nasir Mahmood, and Ammad Ahmad Farooqi19. Metastasis-inhibitory Role of Blueberries: Time to Play Gooseberry with Oncogenic Cascades and MetastasisAmmad Ahmad Farooqi, Ulku Ozbey, Tatiana Colombo Pimentel, Rukset Attar20. The role of ATP-binding cassette transporter genes in the metastatic process of epithelial thyroid carcinoma with aggressive behaviorJoan Carles Escol�-Gil 21. The role of epigenetics in cancer metastasisMadeline Farmer, Kristina Redd, Tinsley Roberson, Metta Smith, and Kayla Lewis Steed22. Regulation of angiogenesis in tumor metastasis via Ets- related ERG and micro RNAs; one hand washes otherNaila Malkani, Muhammad Usman Rashid, Sidra Mumtaz, Muhammad Imran Sohail
Authors
Ammad Ahmad Farooqi Senior Scientist, Institute of Biomedical and Genetic Engineering (IBGE), Islamabad, Pakistan. Ammad Ahmad Farooqi is currently serving as a Senior Scientist at Institute of Biomedical and Genetic Engineering (IBGE). His research-work is tightly focused on cell signaling cascades and how these pathways can be therapeutically exploited. He has published more than 200 articles in International peer-reviewed Journals and has guest edited 2 Books. He has over 5000 citations and an H-index above 37. He is editor of various national and international Journals. He has guest edited various thematic issues related to molecular oncology. He has authored/co- authored more than 25 chapters in various books published by internationally distinguished publishers. He was ranked in the top 10 scientists of biological sciences for 2017/2018 by most prestigious national research steering body, Pakistan Council of Science and Technology (PCST). He was ranked in top 2% scientists of the world in the field of oncology in 2019/2020. According to recently published research, he was ranked as No. 1 Scientist in the field of breast cancer research in Pakistan. Muhammad Zahid Qureshi Professor of Biochemistry, Government College University, Lahore, PakistanProfessor of Biochemistry, Qassim University, Malidah Al Qassim, Saudi Arabia. Muhammad Zahid Qureshi, PhD is a Professor of Biochemistry in Qassim University, Saudi Arabia. He received his PhD from Quaid-i-Azam University Islamabad and post-doctorate from Brunel University, London. He has notable contributions in Biochemistry and Molecular Biology. He has authored/co-authored many articles in international Journals and has published seven chapters. His research is focused on molecular cancer and nanotechnology. Uteuliyev Yerzhan Sabitaliyevi Scientific Center for Innovative Technologies and Research, Kazakhstan. Uteuliyev Yerzhan Sabitaliyevich is an academician and reputed scientist from Kazakhstan. He has previously served as a Vice-Rector for academic affairs and research and innovation activities of Kazakhstan Medical University "KSPH". He has notable contributions in scientifically distinguished international journals. He has played key role in inspiring young researchers to make progress in medical field. He has organized series of medical conferences in Kazakhstan to maximize the interaction of local researchers with scientifically eminent researchers from technically advanced countries.
