The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches.
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Table of Contents
1. Tackling the heterogeneity of bipolar disorder in the era of the Research Domain Criteria (RDoC) 2. The neurodevelopmental basis of Bipolar Disorder: Mechanisms and Implications 3. The neuroprogressive nature of Bipolar Disorder: Mechanisms and Implications 4. Immune mechanisms in Bipolar Disorder: evidence and implications 5. Mitochondrial pathways in Bipolar Disorder: mechanisms and implications 6. Neuro-oxidative and neuro-nitrosative mechanisms in bipolar disorder: evidence and implications 7. Mechanisms underpinning neurocognitive dysfunction in bipolar disorder 8. The evolution of animal models for bipolar disorder 9. Alteration in Circadian rhythms in bipolar disorder: mechanisms and implications 10. The genetics of bipolar disorder 11. Pharmacogenomics of bipolar disorder 12. Blood-brain barrier dysfunction as a pathophysiological mechanism of bipolar disorder 13. Induced Pluripotent stem cells as tools for the investigation of the neurobiology of bipolar disorder 14. Bipolar disorder as a gliopathy 15. Molecular Imaging findings in Bipolar disorder 16. Structural and functional neuroimaging findings in bipolar disorder 17. Epigenetic mechanisms of bipolar disorder 18. Bipolar disorder and cardiovascular dysfunction: mechanisms and implications 19. At-risk mental states for bipolar disorder 20. Stress, allostatic load and bipolar disorder: mechanisms and implications 21. Bipolar disorder, obesity and metabolic disturbances: mechanisms and implications 22. The gut-brain axis in bipolar disorder 23. The hypothalamic-pituitary-adrenal axis in bipolar disorder 24. Disturbed neuroplasticity pathways in bipolar disorder: mechanisms and implications 25. Aberrations in intracellular signaling pathways in bipolar disorder 26. The impact of early-life stress in the development and course of bipolar disorder: mechanisms and implications 27. Bipolar disorder and accelerated aging: mechanisms and implications 28. Suicidal behaviors in bipolar disorder 29. Pediatric bipolar disorder 30. Late-life bipolar disorder 31. Biomarkers for Bipolar Disorder 32. The mechanisms of action of lithium in bipolar disorder 33. Is there a biosignature for lithium response in bipolar disorder? Evidence and implications 34. Exercise as a treatment for bipolar disorder 35. Non-invasive neuromodulatory approaches for bipolar disorder 36. Novel therapeutic drug targets for bipolar disorder 37. The treatment of bipolar disorder in the era of precision psychiatry: challenges and opportunities
Authors
Joao Quevedo Professor of Psychiatry at the McGovern Medical School, The University of Texas Health Science Center at Houston, TX, USA.Dr. Jo�o Luciano de Quevedo, MD, PhD, is a Professor of Psychiatry at the McGovern Medical School, the University of Texas Health Science Center at Houston, where he is the Vice-Chair for Faculty Development and Outreach, Director of the Translational Psychiatry Program, and Director of the Treatment-Resistant Depression Clinic. Before moving to Houston, he was a Dean at the University of Southern Santa Catarina Medical School, Crici�ma, SC, Brazil, where he is still an Adjunct Professor of Psychiatry. He is also Editor-in-Chief of the Brazilian Journal of Psychiatry and Director of the Continuous Medical Education Program in Psychiatry (PROPSIQ) of the Brazilian Psychiatric Association. Dr. Quevedo's research interest is neurobiology of psychiatric disorders, particularly mood disorders, and he is a specialist in both unipolar and bipolar treatment-resistant depression. He is author of nearly 600 publications and 10 scientific books.
Andre Ferrer Carvalho Associate Professor, Department of Psychiatry, Temerty Medical School, University of Toronto, Toronto, ON, Canada. Andr� F Carvalho is associate professor at the Department of Psychiatry at the University of Toronto and a clinician scientist at the Centre for Addiction and Mental Health (CAMH). He was elected member of the board of councilors of the International Society of Bipolar Disorders (2016-2017) and the vice-chair of the section of private practice psychiatry of the World Psychiatric Association (2015-2017). He sits on the editorial board of several international peer-reviewed journals, including Psychotherapy and Psychosomatics, and has served as a peer reviewer for several leading journals and funding agencies. He is an expert in mood disorders, psychiatric epidemiology, and evidence-based mental health. Dr. Carvalho is a sought after speaker in several national and international meetings, and is the author of over 300 publications. Eduard Vieta Professor of Psychiatry and Chair, University of Barcelona, Spain; Head of the Department of Psychiatry and Psychology at the Hospital Clinic and Scientific. Eduard Vieta is Professor of Psychiatry at the University of Barcelona and Chair of the Department of Psychiatry and Psychology at the Hospital Clinic, where he also leads the Bipolar Disorders Program in Barcelona, Catalonia, Spain. The Bipolar Unit is one of the worldwide leaders in clinical care, teaching and research on bipolar disorder.Dr. Vieta is the current Director of the Bipolar Research Program at the Spanish Research Network on Mental Diseases (CIBERSAM), funded by the Spanish Ministry of Economy and Competitiveness. Professor Vieta has received several awards, including the Aristotle award (2005), the Mogens Schou award (2007), the Strategic Research award of the Spanish Society of Biological Psychiatry (2009), the Official College of Physicians award to Professional Excellence (2011) and the Colvin Price on Outstanding Achievement in Mood Disorders Research by the Brain and Behaviour Research Foundation (2012).
He has made significant contributions to many of the published bipolar disorder treatment guidelines and has authored more than 500 original articles, 350 book chapters and 30 complete books. His H index is 66 and has over 16000 citations, which makes him the most cited scientist worldwide in the field of bipolar disorder over the last 5 years. Furthermore, he is on the editorial board of a range of international scientific journals and has served as invited professor at Harvard University and as neuroscience scientific advisor to the European Presidency.
