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Recent Highlights in the Discovery and Optimization of Crop Protection Products

  • ID: 5137689
  • Book
  • March 2021
  • Elsevier Science and Technology

Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete.

Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field.

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Preface Peter Maienfisch and Sven Mangelinckx 1. Recent innovation in crop protection research Peter Maienfisch and Sven Mangelinckx 2. Status and potential of bioprotection products for crop protection Pamela G. Marrone 3. Research and development of green pesticides in China Xusheng Shao, Zhong Li and Xuhong Qian 4. Agrochemical disease control: The story so far Clemens Lamberth, Stefano Rendine and Sarah Sulzer-Mosse 5. Plant defense priming in the field: a review Willem Desmedt, Bartel Vanholme and Tina Kyndt 6. Reaching beyond crop protection: Synergism between agricultural development and malaria eradication Daniel Strickman, Nick Hamon, Thomas S. Churcher, Ellie Sherrard-Smith and Derek W. Willis 7. Discovery and optimization of a novel insecticide, broflanilide T. Nakao, H. Katsuta, M. Nomura, T. Wakita, H. Daido, Y. Kobayashi, A. Kawahara and S. Banba 8. Studies on a novel insecticide, fluxametamide T. Mita, Y. Furukawa, M. Iwasa, T. Kikuchi and M. Komoda 9. The discovery of isocycloseram: A novel isoxazoline insecticide Jérôme Cassayre, Tomas Smejkal, Judith Blythe, Patrik Hoegger, Peter Renold, Thomas Pitterna, C.S. Prasanna, Helmars Smits, Edouard Godineau, Torsten Luksch, Guillaume Berthon, Girish Rawal, Rupesh Patre, Mukul Lal, Mohamed Boussemghoune, Simonetta Masala, Fabien Barreteau, Michael Flaeschel, Juliane Vogt and Myriem El Qacemi 10. Cyclaniliprole: A novel diamide insecticide Masamitsu Tsukamoto, Taku Hamamoto, Masayuki Morita, Kenichi Nakamoto, Akihiro Hisamatsu and Toru Koyanagi 11. Optimization of mesoionic pyrido[1,2-a]pyrimidinone insecticides and discovery of 3-biaryl analogs controlling Lepidoptera species Wenming Zhang, Kenneth A. Hughes, Caleb W. Holyoke Jr., My-Hanh T. Tong, George P. Lahm, Thomas F. Pahutski, James Barry, Daniel Cordova, Robert M. Leighty, Ming Xu, Twyla A. Briddell, Stephen F. McCann, Yewande T. Henry and Yuzhong Chen 12. Chemistry and biology connected: the development of Inscalis Christopher Koradin, Hartwig Schröder, Kazuhiko Oyama and Satoshi Omura 13. Spiropidion discovery: Broad spectrum control of sucking insects and mites for multicrop utility M. Muehlebach, J. Schaetzer, A. Buchholz, A.J. Flemming, C.R. Godfrey, E. Godineau, M. Hamer, F. Vock-Hatt, O. Hueter, D.P. Kloer, P. Maienfisch, S. Oliver, F. Perruccio, Thomas Pitterna, C. Popp, R. Senn, R. Slater, Tomas Smejkal, D. Stafford, J. Wenger, L. Wildsmith and W. Zambach 14. Discovery of oxazosulfyl: A novel broad-spectrum insecticide Mai Ito, Yoshihiko Nokura, Masaki Takahashi, Hiroji Yamada and Atsushi Iwata 15. Synthesis and biological activity of a novel insecticide, benzpyrimoxan Eikoh Satoh, Ryota Kasahara, Kosuke Fukatsu, Takao Aoki, Hiroto Harayama, Tetsuya Murata and Akiyuki Suwa 16. Discovery and optimization of silicon-containing complex II acaricides Cong Zhou, Jiagao Cheng, Zhong Li and Peter Maienfisch 17. Cycloclavine: A natural product with insecticidal potential Joachim Dickhaut, Andrea Molt and Johannes Röckl 18. Photoresponsive pesticidal agents Xusheng Shao 19. Discovery and optimization of novel mosquitocidal compounds for the control of anopheline vectors of malaria P. Wege, O. Hueter, M. Hoppé, Peter Maienfisch, R. Nourani and M. Daniels 20. Antiparasitic dinitrile compounds for fly control in cattle Nikolas Huwyler, Vincent L. Salgado, Pascal Bindschaedler, Birgit Gockel, Matthias Pohlman, Sebastian Soergel, Douglas D. Anspaugh, Ralph Paulini, Nancy B. Rankl, James S. Hunter III and Charles Meng 21. Design, structural derivation, and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives Xiaoyong Xu, Xiulei Chen, Gaolei Wang, Jingwei Zhang, Youxin Xiao, Hongfeng Shen, Yaning Chang, Wei Li, Haowu Jia, Ruifeng Zhang and Xiaofeng Cao 22. ADEPIDYN-the first N-methoxy-substituted carboxamide among the succinate dehydrogenase inhibitors Daniel Stierli, Hans Ulrich Haas, Ramya Rajan, Dave Bartlett, Helge Sierotzki, Fredrik Cederbaum, Harald Walter and Clemens Lamberth 23. Isoflucypram-the next-generation succinate dehydrogenase inhibitor fungicide Anika Bartholomaeus, Peter Dahmen, Philippe Desbordes, Bernd Essigmann, Stephanie Gary, Oliver Gutbrod, Jochen Kleemann, Peter Lancashire, Michael Maue, Hans-Georg Schwarz and Helen Tinwell 24. Discovery and biological profile of inpyrfluxam: A new broad-spectrum succinate dehydrogenase inhibitor fungicide So Kiguchi, Takuya Inoue, Yuichi Matsuzaki, Fukumatsu Iwahashi and Hiroshi Sakaguchi 25. Isofetamid: Discovery and optimization of a novel fungicide T. Yoneda, Y. Nakamura, S. Tsukuda, Y. Abe, M. Matsumoto and S. Mitani 26. Discovery of the trifluoromethyloxadiazoles-a new class of fungicides with a novel mode-of-action Christian Winter and Marcus Fehr 27. The discovery of metyltetraprole: Reconstruction of the quinone outside inhibitor extended pharmacophore to overcome QoI-resistant strains Yuichi Matsuzaki, Yuya Yoshimoto, Sadayuki Arimori and Fukumatsu Iwahashi 28. The discovery of florylpicoxamid, a new picolinamide for disease control Kevin G. Meyer, Chenglin Yao, Yu Lu, Karla Bravo-Altamirano, Zachary Buchan, John F. Daeuble, Kyle DeKorver, Jonathan DeLorbe, Ron Heemstra, Jessica Herrick, David Jones, Brian A. Loy, Jared Rigoli, Nick X. Wang, Jeremy Wilmot and David Young 29. Discovery and validation of pesticide novel target: take pyruvate kinase as an example Bin Zhao, Lai Chen, Jingao Dong and Zhijin Fan 30. Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide Mamiko Shino, Takahiro Hamada, Yoshio Shigematsu, Kangetsu Hirase, Shinichi Banba, Yoshihisa Tsukamoto and Junji Kadotani 31. Toward a mechanistic understanding of IGPD: A potential herbicide target Russell Viner 32. Isoxazolopyridines-a novel chemical cluster and a new (?) mode of action for dicot weed control Thomas Seitz, Ruth Campe and Anna Michrowska-Pianowska 33. Quinazoline-2,4-dione: A promising scaffold for herbicide discovery Ren-Yu Qu, Jia-Xu Nan, Yao-Chao Yan, Hong-Yan Lin, Wen-Chao Yang and Guang-Fu Yang 34. Tirexorâ -design of a new resistance breaking protoporphyrinogen IX oxidase inhibitor Matthias Witschel, Raphael Aponte, Gregory Armel, Peter Bowerman, Thomas Mietzner, Trevor Newton, Aimone Porri, Anja Simon and Thomas Seitz 35. Rinskor active herbicide-A new environment-friendly tool for weed management in rice and aquatic environments Rafael Herrera, Monte R. Weimer, Mauricio Morell, Patrick L. Havens, Giovanna Meregalli, Sabitha Papineni, Laura A. Laughlin and Guomin Shan 36. Discovery of a novel uracil herbicide by using intermediate derivatization approach Jichun Yang, Aiying Guan, Qiao Wu, Dongliang Cui, Hongjuan Ma and Changling Liu 37. Herbicidal activity and application of 1-(furan-2-yl)methylphosphonates as pyruvate dehydrogenase complex inhibitor against broadleaf weeds Hong-Wu He, Yuan Zhou, Hao Peng, Tao Wang, Xiao-song Tan and Jun-Lin Yuan 38. Pesticide activities evaluation of b -carboline, dihydro-b -carboline, tetrahydro-b -carboline alkaloids, and their derivatives Hongjian Song, Jingjing Zhang, Yongqiang Li and Qingmin Wang 39. Marine natural products and plant virus control Ziwen Wang, Aidang Lu and Qingmin Wang 40. Design, synthesis, and biological evaluation of strigolactone derivatives for crop enhancement applications Alain De Mesmaeker, Alexandre Lumbroso, Claudio Screpanti, Katrin Hermann, Mathilde Lachia and Raymonde Fonné-Pfister 41. Discovery and optimization of novel plant activators through structure-based virtual screening Qinjie Shi, Yanxia Shi, Kang Chang, Zheng Xu, Pengfei Li, Zhenjiang Zhao, Weiping Zhu, Honglin Li, BaoJu Li, Xuhong Qian and Yufang Xu

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Peter Maienfisch Founder and owner--CreInSol MCB
Honorary professor--East China University of Science and Technology
Lecturer--University of Basel, Switzerland. Peter Maienfisch is founder and owner of CreInSol MCB, honorary professor at the East China University of Science and Technology, Shanghai, China and lecturer at the University of Basel, Switzerland. Previously he held various management positions in crop protection research and development at Ciba, Novartis and Syngenta, most recently as Research Portfolio Manager Insect Control & Seedcare at Syngenta Crop Protection AG in Switzerland (until April 2020).
His track record of innovation and successful introduction of new technologies includes the authorship of more than 200 scientific papers and patents, the invention of Thiamethoxam (Actara®, Cruiser®), one of the leading insecticides worldwide, and major contributions to the discovery of several new active ingredients currently in worldwide development, such as spiropidion, isocycloseram, cyclobutrifluram and a malaria vector control agent. His scientific contributions also led to numerous invitations as speaker and/or co-organizer of many international congresses, including IUPAC Crop Protection congresses. Ir. Sven Mangelinckx Co-Director--SynBioC Research Group
Ghent University, Belgium. Sven Mangelinckx is co-director of the SynBioC Research Group, Ghent University, Belgium. SynBioC is broadly active in the synthesis of medicinal and crop protection compounds, isolation of natural products, modification of bioresources, green chemistry, microreactor technology and chemical biology.
He obtained a PhD in chemistry in 2006 at Ghent University. Afterwards, he was a postdoctoral fellow of the Scientific Research Fund of Flanders with a research stay at the RWTH Aachen, Germany and received the Thieme Chemistry Journal Award in 2013. Since 2013, he is professor at the Department of Green Chemistry and Technology, (co-)author of 100 scientific papers, >100 conference abstracts, and (co-)promoter of 16 PhD students. He has been acting as organic chemistry section editor of Molecules, co-chairman of Bioheterocycles 2019 and national chairman of the scientific committee of topic 3 'Discovery and Optimization of Crop Protection Products' of the 14th International IUPAC Congress on Crop Protection.
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