Pedigree Analysis in R gives an introduction to the theory of relatedness and covers a range of applications in forensic and medical genetics. The book's material was developed through teaching courses on genetic relatedness, pedigree analysis and R, and offers insights from a decade of research activities in forensic and medical genetics. The R code in the book uses the ped suite, a unified collection of packages for pedigree analysis, developed by the author. All code examples are given in full, allowing accurate reproduction of figures and results. At the end of each chapter, a selection of exercises encourages the reader to explore further and perform their own analyses.
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Table of Contents
1. Prerequisites2. Pedigrees and Marker Data3. Coefficients of Relatedness4. Realised Relatedness5. Probabilities on Pedigrees6. Kinship Testing7. Inference of Pairwise Relatedness8. Pedigree Reconstruction9. Linkage Analysis10. Segregation Analysis for Variant Interpretation
