HLA from Benchtop to Bedside

Table of Contents

1. Introduction and some history2. The structure of the Major Histocompatibility Complex and major HLA components3. Nomenclature and naming conventions for HLA4. The Crossmatch5. HLA antibody detection (screening) and identification6. HLA typing by serologic methods7. HLA typing by molecular methods8. Massively parallel (Next Generation) sequencing9. HLA alleles, disease associations and HLA pharmacogenetics10. Engraftment monitoring

Authors

A. Bradley Eisenbrey Clinical Associate Professor of Pathology, Wayne State University School of Medicine and the University of Toledo College of Medicine and Health Sciences. Arthur Bradley Eisenbrey, MD, PhD is a Clinical Associate Professor of Pathology, Wayne State University School of Medicine and the University of Toledo College of Medicine and Health Sciences. Semi-retired Transplant Immunologist and Specialist in Transfusion Medicine. He formerly directed Immunogenetics (HLA) laboratories at the Detroit Medical Center/Wayne State University, William Beaumont Hospital, Royal Oak, MI, Gift of Life Michigan and Henry Ford Hospital, Detroit, MI. Retired as a Colonel in the reserves of the United States Air Force. Board Certified in Anatomic and Clinical Pathology with subspecialty Board Certification in Blood Banking/Transfusion Medicine. Has served as chairperson of national committees of the AABB and College of American Pathologists (CAP) and continues to serve as a laboratory inspector for the CAP.