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Acute lymphocytic leukemia (ALL) - Market Insight, Epidemiology and Market Forecast -2032

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    Report

  • 200 Pages
  • January 2022
  • Region: Global
  • DelveInsight
  • ID: 5144508

Current Treatment Practices, Emerging Drugs, Market Share of Individual Therapies, and Forecasts to 2030

This "Acute lymphocytic leukemia (ALL)- Market Insights, Epidemiology, and Market Forecast-2032" report delivers an in-depth understanding of the Acute lymphocytic leukemia (ALL), historical and forecasted epidemiology as well as the Acute lymphocytic leukemia (ALL) market trends in the United States, EU5 (Germany, Spain, Italy, France, and United Kingdom) and Japan.

The Acute lymphocytic leukemia (ALL) market report provides current treatment practices, emerging drugs, Acute lymphocytic leukemia (ALL) market share of the individual therapies, current and forecasted Acute lymphocytic leukemia (ALL) market Size from 2019 to 2032 segmented by seven major markets. The Report also covers current Acute lymphocytic leukemia (ALL) treatment practice/algorithm, market drivers, market barriers and unmet medical needs to curate best of the opportunities and assesses the underlying potential of the market.

Geography Covered

  • The United States
  • EU5 (Germany, France, Italy, Spain, and the United Kingdom)
  • Japan

Study Period: 2019-2032

Acute lymphocytic leukemia (ALL) Disease Understanding and Treatment Algorithm


The Acute lymphocytic leukemia (ALL) market report gives a thorough understanding of the Acute lymphocytic leukemia (ALL) by including details such as disease definition, symptoms, causes, pathophysiology, diagnosis and treatment.

Diagnosis


This segment of the report covers the detailed diagnostic methods or tests for Acute lymphocytic leukemia (ALL).

Treatment


It covers the details of conventional and current medical therapies available in the Acute lymphocytic leukemia (ALL) market for the treatment of the condition. It also provides Acute lymphocytic leukemia (ALL) treatment algorithms and guidelines in the United States, Europe, and Japan.

Acute lymphocytic leukemia (ALL) Epidemiology


The Acute lymphocytic leukemia (ALL) epidemiology division provide insights about historical and current Acute lymphocytic leukemia (ALL) patient pool and forecasted trend for every seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of The report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings


The disease epidemiology covered in the report provides historical as well as forecasted Acute lymphocytic leukemia (ALL) epidemiology scenario in the 7MM covering the United States, EU5 countries (Germany, Spain, Italy, France, and the United Kingdom), and Japan from 2019 to 2032.

Country Wise- Acute lymphocytic leukemia (ALL) Epidemiology


The epidemiology segment also provides the Acute lymphocytic leukemia (ALL) epidemiology data and findings across the United States, EU5 (Germany, France, Italy, Spain, and the United Kingdom), and Japan.

Acute lymphocytic leukemia (ALL) Drug Chapters


Drug chapter segment of the Acute lymphocytic leukemia (ALL) report encloses the detailed analysis of Acute lymphocytic leukemia (ALL) marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the Acute lymphocytic leukemia (ALL) clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

Marketed Drugs


The report provides the details of the marketed product available for Acute lymphocytic leukemia (ALL) treatment.

Acute lymphocytic leukemia (ALL) Emerging Drugs


The report provides the details of the emerging therapies under the late and mid-stage of development for Acute lymphocytic leukemia (ALL) treatment.

Acute lymphocytic leukemia (ALL) Market Outlook


The Acute lymphocytic leukemia (ALL) market outlook of the report helps to build the detailed comprehension of the historic, current, and forecasted Acute lymphocytic leukemia (ALL) market trends by analyzing the impact of current therapies on the market, unmet needs, drivers and barriers and demand of better technology.

This segment gives a thorough detail of Acute lymphocytic leukemia (ALL) market trend of each marketed drug and late-stage pipeline therapy by evaluating their impact based on annual cost of therapy, inclusion and exclusion criteria's, mechanism of action, compliance rate, growing need of the market, increasing patient pool, covered patient segment, expected launch year, competition with other therapies, brand value, their impact on the market and view of the key opinion leaders. The calculated market data are presented with relevant tables and graphs to give a clear view of the market at first sight.

According to the publisher, Acute lymphocytic leukemia (ALL) market in 7MM is expected to change in the study period 2019-2032.

Key Findings


This section includes a glimpse of the Acute lymphocytic leukemia (ALL) market in 7MM.

The United States Market Outlook


This section provides the total Acute lymphocytic leukemia (ALL) market size and market size by therapies in the United States.

EU-5 Countries: Market Outlook


The total Acute lymphocytic leukemia (ALL) market size and market size by therapies in Germany, France, Italy, Spain, and the United Kingdom is provided in this section.

Japan Market Outlook


The total Acute lymphocytic leukemia (ALL) market size and market size by therapies in Japan is also mentioned.

Acute lymphocytic leukemia (ALL) Drugs Uptake


This section focusses on the rate of uptake of the potential drugs recently launched in the Acute lymphocytic leukemia (ALL) market or expected to get launched in the market during the study period 2019-2032. The analysis covers Acute lymphocytic leukemia (ALL) market uptake by drugs; patient uptake by therapies; and sales of each drug.

This helps in understanding the drugs with the most rapid uptake, reasons behind the maximal use of new drugs and allow the comparison of the drugs on the basis of market share and size which again will be useful in investigating factors important in market uptake and in making financial and regulatory decisions.

Acute lymphocytic leukemia (ALL) Pipeline Development Activities


The report provides insights into different therapeutic candidates in Phase II, and Phase III stage. It also analyses Acute lymphocytic leukemia (ALL) key players involved in developing targeted therapeutics.

Pipeline Development Activities


The report covers the detailed information of collaborations, acquisition and merger, licensing, patent details and other information for Acute lymphocytic leukemia (ALL) emerging therapies.

Reimbursement Scenario in Acute lymphocytic leukemia (ALL)


Approaching reimbursement proactively can have a positive impact both during the late stages of product development and well after product launch. In a report, we take reimbursement into consideration to identify economically attractive indications and market opportunities. When working with finite resources, the ability to select the markets with the fewest reimbursement barriers can be a critical business and price strategy.

KOL-Views


To keep up with current market trends, we take KOLs and SME's opinion working in Acute lymphocytic leukemia (ALL) domain through primary research to fill the data gaps and validate our secondary research. Their opinion helps to understand and validate current and emerging therapies treatment patterns or Acute lymphocytic leukemia (ALL) market trend. This will support the clients in potential upcoming novel treatment by identifying the overall scenario of the market and the unmet needs.

Competitive Intelligence Analysis


The publisher performs Competitive and Market Intelligence analysis of the Acute lymphocytic leukemia (ALL) Market by using various Competitive Intelligence tools that include - SWOT analysis, PESTLE analysis, Porter's five forces, BCG Matrix, Market entry strategies etc. The inclusion of the analysis entirely depends upon the data availability.

Scope of the Report

  • The report covers the descriptive overview of Acute lymphocytic leukemia (ALL), explaining its causes, signs and symptoms, pathophysiology, diagnosis and currently available therapies
  • Comprehensive insight has been provided into the Acute lymphocytic leukemia (ALL) epidemiology and treatment in the 7MM
  • Additionally, an all-inclusive account of both the current and emerging therapies for Acute lymphocytic leukemia (ALL) are provided, along with the assessment of new therapies, which will have an impact on the current treatment landscape
  • A detailed review of Acute lymphocytic leukemia (ALL) market; historical and forecasted is included in the report, covering drug outreach in the 7MM
  • The report provides an edge while developing business strategies, by understanding trends shaping and driving the global Acute lymphocytic leukemia (ALL) market

Report Highlights

  • In the coming years, Acute lymphocytic leukemia (ALL) market is set to change due to the rising awareness of the disease, and incremental healthcare spending across the world; which would expand the size of the market to enable the drug manufacturers to penetrate more into the market
  • The companies and academics are working to assess challenges and seek opportunities that could influence Acute lymphocytic leukemia (ALL) R&D. The therapies under development are focused on novel approaches to treat/improve the disease condition
  • Major players are involved in developing therapies for Acute lymphocytic leukemia (ALL). Launch of emerging therapies will significantly impact the Acute lymphocytic leukemia (ALL) market
  • A better understanding of disease pathogenesis will also contribute to the development of novel therapeutics for Acute lymphocytic leukemia (ALL)
  • Our in-depth analysis of the pipeline assets across different stages of development (Phase III and Phase II), different emerging trends and comparative analysis of pipeline products with detailed clinical profiles, key cross-competition, launch date along with product development activities will support the clients in the decision-making process regarding their therapeutic portfolio by identifying the overall scenario of the research and development activities

Acute lymphocytic leukemia (ALL) Report Insights

  • Patient Population
  • Therapeutic Approaches
  • Acute lymphocytic leukemia (ALL) Pipeline Analysis
  • Acute lymphocytic leukemia (ALL) Market Size and Trends
  • Market Opportunities
  • Impact of upcoming Therapies

Acute lymphocytic leukemia (ALL) Report Key Strengths

  • 11 Years Forecast
  • 7MM Coverage
  • Acute lymphocytic leukemia (ALL) Epidemiology Segmentation
  • Key Cross Competition
  • Highly Analyzed Market
  • Drugs Uptake

Acute lymphocytic leukemia (ALL) Report Assessment


Current Treatment Practices
  • Unmet Needs
  • Pipeline Product Profiles
  • Market Attractiveness
  • Market Drivers and Barriers

Key Questions Answered


Market Insights:

  • What was the Acute lymphocytic leukemia (ALL) market share (%) distribution in 2019 and how it would look like in 2032?
  • What would be the Acute lymphocytic leukemia (ALL) total market size as well as market size by therapies across the 7MM during the forecast period (2019-2032)?
  • What are the key findings pertaining to the market across 7MM and which country will have the largest Acute lymphocytic leukemia (ALL) market size during the forecast period (2019-2032)?
  • At what CAGR, the Acute lymphocytic leukemia (ALL) market is expected to grow in 7MM during the forecast period (2019-2032)?
  • What would be the Acute lymphocytic leukemia (ALL) market outlook across the 7MM during the forecast period (2019-2032)?
  • What would be the Acute lymphocytic leukemia (ALL) market growth till 2032, and what will be the resultant market Size in the year 2032?
  • How would the market drivers, barriers and future opportunities affect the market dynamics and subsequent analysis of the associated trends?

Epidemiology Insights:

  • What is the disease risk, burden and unmet needs of the Acute lymphocytic leukemia (ALL)?
  • What is the historical Acute lymphocytic leukemia (ALL) patient pool in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
  • What would be the forecasted patient pool of Acute lymphocytic leukemia (ALL) in seven major markets covering the United States, EU5 (Germany, Spain, France, Italy, UK), and Japan?
  • What will be the growth opportunities in the 7MM with respect to the patient population pertaining to Acute lymphocytic leukemia (ALL)?
  • Out of all 7MM countries, which country would have the highest prevalent population of Acute lymphocytic leukemia (ALL) during the forecast period (2019-2032)?
  • At what CAGR the population is expected to grow in 7MM during the forecast period (2019-2032)?

Current Treatment Scenario, Marketed Drugs and Emerging Therapies:

  • What are the current options for the Acute lymphocytic leukemia (ALL) treatment, along with the approved therapy?
  • What are the current treatment guidelines for the treatment of Acute lymphocytic leukemia (ALL) in the USA, Europe, and Japan?
  • What are the Acute lymphocytic leukemia (ALL) marketed drugs and their MOA, regulatory milestones, product development activities, advantages, disadvantages, safety and efficacy, etc.?
  • How many companies are developing therapies for the treatment of Acute lymphocytic leukemia (ALL)?
  • How many therapies are developed by each company for Acute lymphocytic leukemia (ALL) treatment?
  • How many are emerging therapies in mid-stage, and late stage of development for Acute lymphocytic leukemia (ALL) treatment?
  • What are the key collaborations (Industry - Industry, Industry - Academia), Mergers and acquisitions, licensing activities related to the Acute lymphocytic leukemia (ALL) therapies?
  • What are the recent novel therapies, targets, mechanisms of action and technologies developed to overcome the limitation of existing therapies?
  • What are the clinical studies going on for Acute lymphocytic leukemia (ALL) and their status?
  • What are the key designations that have been granted for the emerging therapies for Acute lymphocytic leukemia (ALL)?
  • What are the global historical and forecasted market of Acute lymphocytic leukemia (ALL)?

Reasons to Buy

  • The report will help in developing business strategies by understanding trends shaping and driving the Acute lymphocytic leukemia (ALL) market
  • To understand the future market competition in the Acute lymphocytic leukemia (ALL) market and Insightful review of the key market drivers and barriers
  • Organize sales and marketing efforts by identifying the best opportunities for Acute lymphocytic leukemia (ALL) in the US, Europe (Germany, Spain, Italy, France, and the United Kingdom) and Japan
  • Identification of strong upcoming players in the market will help in devising strategies that will help in getting ahead of competitors
  • Organize sales and marketing efforts by identifying the best opportunities for Acute lymphocytic leukemia (ALL) market
  • To understand the future market competition in the Acute lymphocytic leukemia (ALL) market

Table of Contents

1. Key Insights2. Executive Summary of Acute lymphocytic leukemia (ALL)3. Competitive Intelligence Analysis for Acute lymphocytic leukemia (ALL)
4. Acute lymphocytic leukemia (ALL): Market Overview at a Glance
4.1. Acute lymphocytic leukemia (ALL) Total Market Share (%) Distribution in 2019
4.2. Acute lymphocytic leukemia (ALL) Total Market Share (%) Distribution in 2032
5. Acute lymphocytic leukemia (ALL): Disease Background and Overview
5.1. Introduction
5.2. Sign and Symptoms
5.3. Pathophysiology
5.4. Risk Factors
5.5. Diagnosis
6. Patient Journey
7. Acute lymphocytic leukemia (ALL) Epidemiology and Patient Population
7.1. Epidemiology Key Findings
7.2. Assumptions and Rationale: 7MM
7.3. Epidemiology Scenario: 7MM
7.3.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in the 7MM (2019-2032)
7.4. United States Epidemiology
7.4.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in the United States (2019-2032)
7.5. EU-5 Country-wise Epidemiology
7.5.1. Germany Epidemiology
7.5.1.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in Germany (2019-2032)
7.5.2. France Epidemiology
7.5.2.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in France (2019-2032)
7.5.3. Italy Epidemiology
7.5.3.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in Italy (2019-2032)
7.5.4. Spain Epidemiology
7.5.4.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in Spain (2019-2032)
7.5.5. United Kingdom Epidemiology
7.5.5.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in the United Kingdom (2019-2032)
7.5.6. Japan Epidemiology
7.5.6.1. Acute lymphocytic leukemia (ALL) Epidemiology Scenario in Japan (2019-2032)
8. Treatment Algorithm, Current Treatment, and Medical Practices
8.1. Acute lymphocytic leukemia (ALL) Treatment and Management
8.2. Acute lymphocytic leukemia (ALL) Treatment Algorithm
9. Unmet Needs10. Key Endpoints of Acute lymphocytic leukemia (ALL) Treatment
11. Marketed Products
11.1. List of Marketed Products in the 7MM
11.2. Drug Name: Company Name
11.2.1. Product Description
11.2.2. Regulatory Milestones
11.2.3. Other Developmental Activities
11.2.4. Pivotal Clinical Trials
11.2.5. Summary of Pivotal Clinical Trial
List to be continued in report
12. Emerging Therapies
12.1. Key Cross
12.2. Drug Name: Company Name
12.2.1. Product Description
12.2.2. Other Developmental Activities
12.2.3. Clinical Development
12.2.4. Safety and Efficacy
12.2.5. Product Profile
List to be continued in report
13. Acute lymphocytic leukemia (ALL): Seven Major Market Analysis
13.1. Key Findings
13.2. Acute lymphocytic leukemia (ALL) Market Size in 7MM
13.3. Acute lymphocytic leukemia (ALL) Market Size by Therapies in the 7MM
14. Attribute analysis
15. 7MM: Market Outlook
15.1. United States: Market Size
15.1.1. Acute lymphocytic leukemia (ALL) Total Market Size in the United States
15.1.2. Acute lymphocytic leukemia (ALL) Market Size by Therapies in the United States
15.2. EU-5 countries: Market Size and Outlook
15.3. Germany Market Size
15.3.1. Acute lymphocytic leukemia (ALL) Total Market Size in Germany
15.3.2. Acute lymphocytic leukemia (ALL) Market Size by Therapies in Germany
15.4. France Market Size
15.4.1. Acute lymphocytic leukemia (ALL) Total Market Size in France
15.4.2. Acute lymphocytic leukemia (ALL) Market Size by Therapies in France
15.5. Italy Market Size
15.5.1. Acute lymphocytic leukemia (ALL) Total Market Size in Italy
15.5.2. Acute lymphocytic leukemia (ALL) Market Size by Therapies in Italy
15.6. Spain Market Size
15.6.1. Acute lymphocytic leukemia (ALL) Total Market Size in Spain
15.6.2. Acute lymphocytic leukemia (ALL) Market Size by Therapies in Spain
15.7. United Kingdom Market Size
15.7.1. Acute lymphocytic leukemia (ALL) Total Market Size in the United Kingdom
15.7.2. Acute lymphocytic leukemia (ALL) Market Size by Therapies in the United Kingdom
15.8. Japan Market Outlook
15.8.1. Japan Market Size
15.8.2. Acute lymphocytic leukemia (ALL) Total Market Size in Japan
15.8.3. Acute lymphocytic leukemia (ALL) Market Size by Therapies in Japan
16. Access and Reimbursement Overview of Acute lymphocytic leukemia (ALL)17. KOL Views18. Market Drivers19. Market Barriers
20. Appendix
20.1. Bibliography
20.2. Report Methodology
21. Publisher Capabilities22. Disclaimer
23. About the Publisher
*The table of contents is not exhaustive; the final content may vary.
List of Tables
Table 1: 7MM Acute lymphocytic leukemia (ALL) Epidemiology (2019-2032)
Table 2: 7MM Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases (2019-2032)
Table 3: Acute lymphocytic leukemia (ALL) Epidemiology in the United States (2019-2032)
Table 4: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in the United States (2019-2032)
Table 5: Acute lymphocytic leukemia (ALL) Epidemiology in Germany (2019-2032)
Table 6: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Germany (2019-2032)
Table 7: Acute lymphocytic leukemia (ALL) Epidemiology in France (2019-2032)
Table 8: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in France (2019-2032)
Table 9: Acute lymphocytic leukemia (ALL) Epidemiology in Italy (2019-2032)
Table 10: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Italy (2019-2032)
Table 11: Acute lymphocytic leukemia (ALL) Epidemiology in Spain (2019-2032)
Table 12: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Spain (2019-2032)
Table 13: Acute lymphocytic leukemia (ALL) Epidemiology in the UK (2019-2032)
Table 14: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in the UK (2019-2032)
Table 15: Acute lymphocytic leukemia (ALL) Epidemiology in Japan (2019-2032)
Table 16: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Japan (2019-2032)
Table 17: Drug Name, Clinical Trials by Recruitment status
Table 18: Drug Name, Clinical Trials by Zone
Table 19: Total Seven Major Market Size in USD, Million (2019-2032)
Table 20: Region-wise Market Size in USD, Million (2019-2032)
Table 21: 7MM-Market Size by Therapy in USD, Million (2019-2032)
Table 22: United States Market Size in USD, Million (2019-2032)
Table 23: United States Market Size by Therapy in USD, Million (2019-2032)
Table 24: Germany Market Size in USD, Million (2019-2032)
Table 25: Germany Market Size by Therapy in USD, Million (2019-2032)
Table 26: France Market Size in USD, Million (2019-2032)
Table 27: France Market Size by Therapy in USD, Million (2019-2032)
Table 28: Italy Market Size in USD, Million (2019-2032)
Table 29: Italy Market Size by Therapy in USD, Million (2019-2032)
Table 30: Spain Market Size in USD, Million (2019-2032)
Table 31: Spain Market Size by Therapy in USD, Million (2019-2032)
Table 32: United Kingdom Market Size in USD, Million (2019-2032)
Table 33: United Kingdom Market Size by Therapy in USD, Million (2019-2032)
Table 34: Japan Market Size in USD, Million (2019-2032)
Table 35: Japan Market Size by Therapy in USD, Million (2019-2032)
*The list of tables is not exhaustive; the final content may vary
List of Figures
Figure 1: 7MM Acute lymphocytic leukemia (ALL) Epidemiology (2019-2032)
Figure 2: 7MM Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases (2019-2032)
Figure 3: Acute lymphocytic leukemia (ALL) Epidemiology in the United States (2019-2032)
Figure 4: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in the United States (2019-2032)
Figure 5: Acute lymphocytic leukemia (ALL) Epidemiology in Germany (2019-2032)
Figure 6: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Germany (2019-2032)
Figure 7: Acute lymphocytic leukemia (ALL) Epidemiology in France (2019-2032)
Figure 8: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in France (2019-2032)
Figure 9: Acute lymphocytic leukemia (ALL) Epidemiology in Italy (2019-2032)
Figure 10: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Italy (2019-2032)
Figure 11: Acute lymphocytic leukemia (ALL) Epidemiology in Spain (2019-2032)
Figure 12: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Spain (2019-2032)
Figure 13: Acute lymphocytic leukemia (ALL) Epidemiology in the UK (2019-2032)
Figure 14: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in the UK (2019-2032)
Figure 15: Acute lymphocytic leukemia (ALL) Epidemiology in Japan (2019-2032)
Figure 16: Acute lymphocytic leukemia (ALL) Diagnosed and Treatable Cases in Japan (2019-2032)
Figure 17: Drug Name, Clinical Trials by Recruitment status
Figure 18: Drug Name, Clinical Trials by Zone
Figure 19: Total Seven Major Market Size in USD, Million (2019-2032)
Figure 20: Region-wise Market Size in USD, Million (2019-2032)
Figure 21: 7MM-Market Size by Therapy in USD, Million (2019-2032)
Figure 22: United States Market Size in USD, Million (2019-2032)
Figure 23: United States Market Size by Therapy in USD, Million (2019-2032)
Figure 24: Germany Market Size in USD, Million (2019-2032)
Figure 25: Germany Market Size by Therapy in USD, Million (2019-2032)
Figure 26: France Market Size in USD, Million (2019-2032)
Figure 27: France Market Size by Therapy in USD, Million (2019-2032)
Figure 28: Italy Market Size in USD, Million (2019-2032)
Figure 29: Italy Market Size by Therapy in USD, Million (2019-2032)
Figure 30: Spain Market Size in USD, Million (2019-2032)
Figure 31: Spain Market Size by Therapy in USD, Million (2019-2032)
Figure 32: United Kingdom Market Size in USD, Million (2019-2032)
Figure 33: United Kingdom Market Size by Therapy in USD, Million (2019-2032)
Figure 34: Japan Market Size in USD, Million (2019-2032)
Figure 35: Japan Market Size by Therapy in USD, Million (2019-2032)
*The list of figures is not exhaustive; the final content may vary

Executive Summary

Acute Lymphocytic Leukemia Overview

Leukemia is a term given to a group of cancers that develop in the blood and bone marrow. It originates in developing blood cells that have undergone a malignant change, which means they multiply in an uncontrolled manner, leaving them unformed and inoperative.

Leukemia can be either acute or chronic. In chronic leukemia, there is an accumulation of mature but abnormal white blood cells that have undergone a malignant change when developing from a blast cell. It progresses more slowly than acute leukemia and may not require treatment for a long time after it is diagnosed.

On the other hand, with acute leukemia, the diseased bone marrow produces an excessive number of abnormal blast cells, called leukemic cells.  These cells accumulate in the bone marrow interfering with the production of normal blood cells. Acute leukemia develops and progresses quickly, and therefore, needs to be treated as soon as it is detected.

Typical forms of acute leukemia include acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL), and acute promyelocytic leukemia (APML).

Acute lymphocytic leukemia (ALL), also known as acute lymphoblastic leukemia, is a type of cancer that affects the blood and bone marrow. It starts from young white blood cells called lymphocytes in the bone marrow; mainly characterized by an overproduction of immature white blood cells, called lymphoblasts or leukemic blasts. Because the bone marrow is unable to make adequate numbers of red cells, normal white cells, and platelets, people with ALL become more susceptible to anemia, recurrent infections, and to bruising and bleeding easily. The blast cells can then spill out of the bone marrow into the bloodstream and accumulate in various organs including the lymph nodes or glands, spleen, liver, and central nervous system (brain and spinal cord).

ALL is mainly classified into B-cell and T-cell ALL. ALL can occur at any age but is more common in young children (0-14 years) and it develops quickly, around 54% of ALL cases in US diagnosed among people aged <20 years. Among children, B-cell lineage ALL constitutes approximately 88% of cases. Among adults, B-cell lineage represents around 75% of cases.

Acute Lymphocytic Leukemia Diagnosis

Certain signs and symptoms can suggest that a person might have ALL, but tests are needed to confirm the diagnosis. During the physical exam, the doctor usually focus on any enlarged lymph nodes, areas of bleeding or bruising, or possible signs of infection. The eyes, mouth, and skin will be looked at carefully, and a thorough nervous system exam may be done. The patient’s abdomen will be checked for spleen or liver enlargement.

If there is reason to think low levels of blood cells might be causing symptoms (anemia, infections, bleeding or bruising, etc.), the doctor will most likely order blood tests to check blood cell counts. The patient might also be referred to a hematologist doctor who specializes in diseases of the blood, including leukemia.

The diagnosis of ALL is mainly done by Blood test (complete blood count (CBC) and peripheral blood smear, blood chemistry tests, blood coagulation tests), Bone marrow test (bone marrow aspiration and biopsy), Lab tests (routine exams with a microscope, cytochemistry tests, flow cytometry and immunohistochemistry), Chromosome tests (fluorescent in situ hybridization (FISH), polymerase chain reaction (PCR)), Imaging tests (computerized Tomography (CT) scan, magnetic resonance imaging (MRI) Scan, and staging).

Acute Lymphocytic Leukemia Treatment

ALL is a malignant clonal disease that usually develops when a lymphoid progenitor cell turns into genetically altered through somatic changes and goes through uncontrolled proliferation. This progression of clonal expansion further leads to ALL. However, common treatment of ALL divided into distinct phases such as Induction therapy, Consolidation therapy, Maintenance therapy, and Preventive treatment to the spinal cord, among others.


  • Induction Therapy - The main purpose of the first phase of treatment is to kill most of the leukemia cells in the bone marrow and blood also to restore normal blood cell production.
  • Consolidation Therapy - Consolidation therapy is also known as post-remission therapy. The main purpose of this therapy is to completely wipe out remaining leukemia in the body, such as in the brain or spinal cord. Consolidation therapy is also known as post-remission therapy.
  • Maintenance Therapy - This is known as the third phase of treatment, which prevents leukemia cells from regrowth. However, the treatment used in this stage is often given at much lesser doses for a long period, often years.
  • Preventive treatment to the spinal cord - In this phase of therapy, a patient suffering from ALL may receive additional treatment from killing leukemia cells which are located in the central nervous system. Also, in this type of treatment phase chemotherapy drugs are often injected directly into the fluid that covers the spinal cord.

The therapies that are approved for the treatment of ALL are Blincyto (blinatumomab/MT 103), Kymriah {CTL019 (tisagenlecleucel)}, Besponsa (inotuzumab ozogamicin), Iclusig (Ponatinib), among others.   

ALL Epidemiology

The ALL epidemiology division provides the insights about historical and current ALL patient pool and forecasted trend for each seven major countries. It helps to recognize the causes of current and forecasted trends by exploring numerous studies and views of key opinion leaders. This part of the report also provides the diagnosed patient pool and their trends along with assumptions undertaken.

Key Findings

In the year 2017, the 7MM total incident case of ALL was 10,341 cases which are expected to grow during the study period, i.e., 2017-2030.

The disease epidemiology covered in the report provides historical as well as forecasted ALL epidemiology [segmented as Total Incident Cases of Leukemia, Total Incident Cases of ALL, Gender-specific cases of ALL, Diagnosed cases of ALL by Age Distribution, Subtype-specific cases of ALL, Genetic mutation-specific cases of ALL, and Total Treated Cases of ALL] scenario of ALL in the 7MM covering United States, EU5 countries (Germany, France, Italy, Spain, and United Kingdom), and Japan from 2017 to 2030.

Country-wise ALL Epidemiology


  • Estimates show that the highest cases of ALL in the 7MM were in the United States, followed by Germany, Japan, France, the United Kingdom, Italy, and Spain in 2017.
  • In the United States, the total number of incident cases of ALL was 5,816 cases in the year 2017 which are expected to grow during the study period, i.e., 2017-2030.
  • In the year 2017, the total incident cases of ALL were 3,652 cases in EU-5 which are expected to grow during the study period, i.e., 2017-2030.
  • In Japan, the total number of incident cases of ALL was 872 cases in the year 2017 which are expected to grow during the study period, i.e., 2017-2030.

 


ALL Drug Chapters

Drug chapter segment of the ALL report encloses the detailed analysis of ALL marketed drugs and late stage (Phase-III and Phase-II) pipeline drugs. It also helps to understand the ALL clinical trial details, expressive pharmacological action, agreements and collaborations, approval and patent details, advantages and disadvantages of each included drug and the latest news and press releases.

ALL Approved Drugs

Blincyto/blinatumomab/MT 103 (Amgen)

Blincyto is a bispecific CD19-directed CD3 T-cell engager (BiTE) immunotherapy that binds to CD19 expressed on the surface of cells of B-lineage origin and CD3 expressed on the surface of T-cells. Blinatumomab possesses two antigen-recognition sites, one for the CD3 complex, a group of T-cell surface glycoproteins that complex with the T-cell receptor (TCR), and one for CD19, a tumor-associated antigen (TAA) overexpressed on the surface of B-cells. This bispecific monoclonal antibody brings CD19-expressing tumor B-cells and cytotoxic T lymphocytes (CTLs) and helper T lymphocytes (HTLs) together, which may result in the CTL- and HTL-mediated cell death of CD19-expressing B-lymphocytes.

In July 2014, the US FDA granted Breakthrough Therapy Designation to Blincyto for adults with Philadelphia-negative (Ph-) relapsed/refractory B-precursor ALL. Before this, in May 2008, the US FDA granted orphan drug designation to blinatumomab for the treatment of ALL.

Furthermore, in July 2009, the European Commission granted orphan drug designation to Micromet AG, Germany, for blinatumomab for the treatment of acute lymphoblastic leukemia.

Asparlas/calaspargase pegol-mknl (Servier Pharmaceuticals)

Asparlas (calaspargase pegol-mknl) is an intravenous formulation containing E.coli-derived L-asparaginase II conjugated with succinimidyl carbonate monomethoxypolyethylene glycol (SC-PEG), with potential antineoplastic activity. L-asparaginase hydrolyzes L-asparagine to L-aspartic acid and ammonia, thus depleting cells of asparagine. Asparagine depletion blocks protein synthesis and tumor cell proliferation, especially in the G1 phase of the cell cycle and ultimately induces tumor cell death. Asparagine is critical to protein synthesis in acute lymphoblastic leukemia (ALL) cells which, unlike normal cells, cannot synthesize this amino acid due to the absence of the enzyme asparagine synthase.

In April 2018, Servier entered into a definitive agreement with the Shire, a leading global biotechnology company focused on rare diseases, to acquire its Oncology business for USD 2.4 Billion. The acquisition allows Servier to establish an immediate and direct commercial presence in the United States, the world’s leading biopharmaceuticals market.

Kymriah/tisagenlecleucel (Novartis Pharmaceuticals)

Kymriah (tisagenlecleucel, formerly CTL019) suspension for intravenous infusion is a CD19-directed genetically modified autologous chimeric antigen receptor T-cell (CAR-T) therapy. It is approved in the US, the EU, Japan, and other countries for the treatment of:
Patients up to 25 years with B-cell acute lymphoblastic leukemia that is refractory or in second or later relapse
Adults with relapsed or refractory diffuse large B-cell lymphoma after two or more lines of systemic therapy

In January 2014, the US FDA granted Orphan drug designation to Kymriah for the treatment of ALL. Likewise in April 2014, Orphan drug designation was granted by the European Commission to Novartis for the treatment of B-lymphoblastic leukemia/lymphoma.

In addition to this, the US FDA granted Kymriah a breakthrough therapy designation for relapsed or refractory B-cell ALL.

Besponsa/inotuzumabozogamicin (Pfizer)

Besponsa is an antibody-drug conjugate (ADC) composed of a monoclonal antibody (mAb) targeting CD22, a cell surface antigen expressed on cancer cells in almost all B-ALL patients, linked to a cytotoxic agent. It is used for the treatment of adults with relapsed or refractory B-cell precursor ALL. When Besponsa binds to the CD22 antigen on B-cells, it is internalized into the cell, where the cytotoxic agent calicheamicin is released causing cell death. Besponsa originated from a collaboration between Pfizer and Cell tech, now UCB.

In March 2013, the US FDA also granted Inotuzumab ozogamicin with the Orphan Designation Status for the treatment of B-cell ALL. Later, in June 2013, the orphan designation was granted by the European Commission to Pfizer for inotuzumab ozogamicin for the treatment of B-cell ALL.

In October 2015, Inotuzumab ozogamicin was granted with Breakthrough Therapy designation from the US FDA for ALL.

Iclusig/Ponatinib (Takeda/Ariad Pharmaceuticals)

Iclusig is an orally administered kinase inhibitor whose primary target is BCR-ABL, an abnormal tyrosine kinase that is expressed in chronic myeloid leukemia (CML) and Philadelphia-chromosome positive acute lymphoblastic leukemia (Ph+ ALL). Iclusig was designed using ARIAD’s computational and structure-based drug-design platform specifically to inhibit the activity of BCR-ABL. It targets not only native BCR-ABL but also its isoforms that carry mutations that confer resistance to treatment, including the T315I mutation, which has been associated with resistance to other approved TKIs.

It is used in the treatment of the following:
Treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) or Ph+ ALL for whom no other tyrosine kinase inhibitor (TKI) therapy is indicated.
Treatment of adult patients with T315I-positive CML (chronic phase, accelerated phase, or blast phase) or T315I-positive Ph+ ALL

Note: Detailed Current therapies assessment will be provided in the full report of ALL

ALL Emerging Drugs

PBCAR0191 (Precision BioSciences/Servier)

Precision BioSciences is investigating their first allogeneic CAR T in Phase I/II clinical trial for relapsed/refractory cases of B-cell ALL and NHL. This product is under investigation in collaboration with Servier. PBCAR0191 is an allogeneic CAR T cell therapy targeting the well-validated tumor target CD19 and is being developed for ALL, and non-hodgkin lymphoma, or NHL. Also, CD19 is a protein that is expressed on the surface of B-cells.

This product is based on the donor-derived T-cells modified using the ARCUS genome editing technology. PBCAR0191 recognizes the well-characterized tumor cell surface protein CD19, an important and validated target in several B-cell cancers. It is designed to avoid graft-versus-host disease, or GvHD, a significant complication associated with donor-derived, cell-based therapies.

AUTO1 (Autolus Limited)

Autolus Limited is also investigating its lead CAR T-cell therapy candidate in pediatric and young adult patients with ALL. It is a CD19 CAR T-cell investigational therapy designed to overcome the limitations in safety - while maintaining similar levels of efficacy - compared to current CD19 CAR T cell therapies. Designed to have a fast target binding off-rate to minimize excessive activation of the programmed T cells, AUTO1 may reduce toxicity and be less prone to T-cell exhaustion, which could enhance persistence and improve the T-cells’ abilities to engage in serial killing of target cancer cells. AUTO1 is Autolus’ most advanced program and recently entered a pivotal study in adult ALL and is also being evaluated in a Phase I study in pediatric ALL.

In April 2020, the US FDA has accepted the IND application for AUTO1, its lead CAR T product candidate for the treatment of adults with ALL. The active IND allows initiation of the US sites in the company’s first pivotal study, AUTO1-AL1. In November 2019, the US FDA granted AUTO1 orphan drug designation for the treatment of ALL patients.

KTE-X19 (Gilead Sciences)

KTE-X19 is an investigational, autologous, anti-CD19 CAR T cell therapy. KTE-X19 uses the XLP manufacturing process that includes T-cell selection and lymphocyte enrichment. Lymphocyte enrichment is a necessary step in certain B-cell malignancies in which circulating lymphoblasts are a common feature. It is a preparation of autologous peripheral blood T lymphocytes (PBTL) that have been transduced with a retroviral vector expressing a chimeric antigen receptor (CAR) consisting of an anti-CD19 single chain variable fragment (scFv) coupled to the costimulatory signaling domain CD28 and the zeta chain of the T-cell receptor (TCR)/CD3 complex (CD3 zeta), with potential immune stimulating and antineoplastic activities. Upon intravenous infusion and re-introduction of autologous anti-CD19 CAR-CD28 T cells KTE-X19 into the patient, these cells bind to and induce selective toxicity in CD19-expressing tumor cells.

UCART19 (Servier/Allogene)

UCART19 is a first-in-class allogeneic CAR T cell product candidate for the treatment of pediatric and adult patients with R/R CD19 positive B-cell ALL. Servier is the sponsor of the UCART19 clinical trials and is also responsible for manufacturing UCART19. This therapy is being jointly developed under a clinical development collaboration between Servier and Allogene based on an exclusive license granted by Cellectis to Servier. UCART19 utilizes TALEN gene-editing technology pioneered and owned by Cellectis.

UCART19 is manufactured to express a CAR that is designed to target CD19 and gene-edited to lack TCRα and CD52 to minimize the risk of GvHD and enable a window of persistence in the patient. In addition, UCART19 cells are engineered to express a small protein on the cell surface called RQR8, which consists of two rituximab recognition domains. This allows for recognition and elimination of cells if silencing of CAR activity is desired.

In February 2020, Cellectis granted additional rights to Servier to develop and commercialize all next-generation gene-edited allogeneic CAR T-cell products targeting CD19, including ALLO-501A.

Lisocabtagene Maraleucel/JCAR017 (Bristol-Myers Squibb)

Lisocabtagene Maraleucel (JCAR017), also known as Liso-cel, is under development by Bristol-Myers Squibb. It is an investigational CAR T-cell therapy designed to target CD19, which is a surface glycoprotein expressed during normal B-cell development and maintained following malignant transformation of B cells. Liso-cel CAR T cells aim to target CD19 expressing cells through a CAR construct that includes an anti-CD19 single-chain variable fragment (scFv) targeting domain for antigen specificity, a transmembrane domain, a 4-1BB co-stimulatory domain hypothesized to increase T-cell proliferation and persistence, and a CD3-zeta T-cell activation domain. The defined composition of CD4+ and CD8+ CAR T cells in liso-cel may limit product variability; however, the clinical significance of defined composition is unknown.

In September 2016, the US FDA granted orphan drug designation to JCAR017 for the treatment of ALL.

Venetoclax/Venclexta/ABT199/RG7601 (AbbVie and Roche)

Venetoclax (Venclexta, Venclyxto) is an oral B-cell lymphoma-2 (BCL-2) inhibitor developed by AbbVie and Genentech. It is used for the treatment of adult patients with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Leukemia (SLL) and in combination with azacitidine or decitabine or low-dose cytarabine for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adults who are aged 75 or older, or who have comorbidities that preclude the use of intensive induction chemotherapy.
Venetoclax helps restore the process of apoptosis by binding directly to the BCL-2 protein, displacing proapoptotic proteins like BIM, triggering mitochondrial outer membrane permeabilization, and the activation of caspases. In nonclinical studies, venetoclax has demonstrated cytotoxic activity in tumor cells that overexpress BCL-2.

JZP-458/PF743/recombinant Erwinia asparaginase (Jazz Pharmaceuticals)

Jazz Pharmaceuticals is investigating JZP-458 for the treatment for pediatric and adult patients with ALL who are hypersensitive to E. coli-derived asparaginases. JZP-458 is a recombinant of Erwinia asparaginase which uses a novel Pseudomonas fluorescens manifestation platform. This product is in development by using the Pfenex’s Expression technology under their agreement with Jazz Pharmaceuticals. Pfenex granted worldwide rights to develop and commercialize multiple early-stage hematology product candidates, including a recombinant Erwinia asparaginase JZP-458 to Jazz pharmaceuticals.

In October 2019, the US Food and Drug Administration granted Fast Track Designation for JZP-458/PF743 for the treatment of ALL.

Daratumumab (Janssen Research & Development)

Daratumumab is a human IgG1k monoclonal antibody that binds with high affinity to the CD38 molecule, which is highly expressed on the surface of multiple myeloma cells. Daratumumab is being developed by Janssen Biotech under an exclusive worldwide license to develop, manufacture and commercialize daratumumab from Genmab. This drug has been already approved by the US FDA to treat multiple myeloma with the brand name Darzalex. Janssen Research & Development had initiated an open-label, multicenter, phase II study evaluating the efficacy and safety of Daratumumab in pediatric and young adult subjects ≥1 and ≤30 years with relapsed/refractory precursor B-cell or T-cell ALL or lymphoblastic lymphoma.

In July 2012, Genmab entered into a collaboration with Janssen Biotech and its affiliates (Janssen) to create and develop bispecific antibodies using its DuoBody technology platform. Genmab created panels of bispecific antibodies to multiple disease target combinations identified by Janssen, who will in turn fully fund research at Genmab.

Imbruvica/Ibrutinib {Pharmacyclics (an AbbVie Company)}

Ibrutinib is an oral small-molecule inhibitor of type of enzyme, called a protein kinase that controls the rate at which certain cells multiply. In particular, ibrutinib has been shown to bind to covalently, and ultimately inhibit, the Bruton’s tyrosine kinase (BTK). BTK plays a primary role in signaling healthy B cells to survive, mature, proliferate and release antibodies.

Since its launch in 2013, Imbruvica had received 11 FDA approvals across six disease areas: chronic lymphocytic leukemia (CLL) with or without 17p deletion (del17p); small lymphocytic lymphoma (SLL) with or without del17p; Waldenström's macroglobulinemia (WM); previously-treated patients with mantle cell lymphoma (MCL); previously-treated patients with marginal zone lymphoma (MZL) who require systemic therapy and have received at least one prior anti-CD20-based therapy and previously-treated patients with chronic graft-versus-host disease (cGVHD) after the failure of one or more lines of systemic therapy.

Note: Detailed emerging therapies assessment will be provided in the final report.

ALL Market Outlook

Chemotherapy is often complex and intense, particularly in the initial months of treatment for ALL. The most common treatment regimens use a combination of more than one anticancer drug. It is broken down into three phases: induction phase, consolidation (or intensification) phase, and maintenance phase. Induction is the first phase of chemotherapy, and the goal of this phase is to induce a remission. In this phase, numerous drugs are usually being used depending on the patient’s age, the specific features of leukemia, and the overall health of the patient. Induction regimens for ALL generally use a combination of drugs that include vincristine; anthracyclines (daunorubicin, doxorubicin); and corticosteroids (prednisone, dexamethasone) administered either with or without asparaginase and/or cyclophosphamide. Even after the complete remission, some leukemia cells still remain in the body. The presence of these cells is referred to as 'minimal residual disease (MRD).' Patients who have MRD, are at increased risk of disease relapse. After a patient achieves a complete remission, postremission therapy is given to kill every remaining leukemia cell in the body.

Oftentimes when residual leukemia cells remain after remission, so the optimal treatment for ALL patients requires additional intensive postremission therapy. The second phase of chemotherapy is called consolidation therapy. The combination of drugs and the duration of therapy for consolidation regimens vary but can consist of combinations of drugs similar to those drugs used during the induction phase. Some drugs which are used in this phase are High-dose methotrexate, Cytarabine, Vincristine, 6-mercaptopurine, Blincyto, Besponsa, Cyclophosphamide, Asparaginase, and Corticosteroids (prednisone, and dexamethasone). The third phase of ALL treatment is called 'maintenance phase.' The goal of maintenance therapy is to prevent disease relapse after induction and consolidation therapy. Most maintenance regimens include 6-mercaptopurine, Methotrexate, Vincristine, Corticosteroids, and Intrathecal chemotherapy.

At present, several pharmaceutical companies are working for the development of novel approach to treat this condition. Key players like KTE-X19 (Gilead Sciences), UCART19 (Servier/Allogene), Lisocabtagene Maraleucel/JCAR017 (Bristol-Myers Squibb), Venetoclax/Venclexta/ABT199/RG7601 (AbbVie and Roche), JZP-458/PF743/recombinant Erwinia asparaginase (Jazz Pharmaceuticals), Daratumumab (Janssen Research & Development), Imbruvica/Ibrutinib {Pharmacyclics (an AbbVie Company)}, AUTO1 (Autolus Limited), PBCAR0191 (Precision BioSciences/Servier), and others.


Companies Mentioned

A selection of companies mentioned in this report includes:

  • AbbVie
  • Allogene
  • Amgen
  • Autolus Limited
  • Bellicum Pharmaceuticals
  • BioLine Rx
  • Bristol-Myers Squibb
  • Fate Therapeutics
  • Gamida Cell Ltd.
  • Gilead Sciences
  • Incyte Corporation
  • Janssen Research & Development
  • Jazz Pharmaceuticals
  • MiltenyiBiotec B.V. & Co. KG
  • Novartis Pharmaceuticals
  • Otsuka Pharmaceuticals
  • Pfizer
  • Pharmacyclics (an AbbVie Company)
  • Porton Biopharma Limited
  • Precision BioSciences
  • Roche
  • Sanofi
  • Servier Pharmaceuticals
  • Takara Bio
  • Takeda (Ariad Pharmaceuticals)
  • TCR2 Therapeutics