The fifth volume of the series features five reviews which demonstrate chemical analysis techniques applied in different disciplines.
- Superior Aspects of Liquid Chromatography-Based Mass Spectrometers in Chiral Analysis
- New Trends in Sample Preparation for Pharmaceutical and Biological Analysis by Chromatographic Methods
- Qualitative and Quantitative Investigation of Bio Tissues using Microscopy and Data Mining
- Analytical Techniques For Analysis of Metals and Minerals in The Soil Samples
- Monitoring Therapeutic Response in Cancers: A Raman Spectroscopy Approach
Table of Contents
PREFACELIST OF CONTRIBUTORS
CHAPTER 1 SUPERIOR ASPECTS OF LIQUID CHROMATOGRAPHY-BASED MASS SPECTROMETERS IN CHIRAL ANALYSIS
Aysegul Dogan, Cemil C. Eylem and Nursabah E. Başcı
- INTRODUCTION
- MASS SPECTROMETRY IN CHIRAL ANALYSIS
- Gas Chromatography-Mass Spectrometry
- Liquid Chromatography-Mass Spectrometry
- Normal Phase and Reverse Phase Liquid Chromatography-Mass Spectrometry
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 2 NEW TRENDS IN SAMPLE PREPARATION FOR PHARMACEUTICAL AND BIOLOGICAL ANALYSIS BY CHROMATOGRAPHIC METHODS
Mario Contin, Cecilia Dobrecky, Sabrina Flor, Manuela Martinefski, Silvia Lucangioli and Valeria Tripodi
- INTRODUCTION
- SAMPLE PREPARATION METHODS
- MONOLITHIC SORBENTS
- Inorganic Monoliths
- Organic Monoliths
- Hybrid Monoliths
- SPE Related Techniques
- Solid Phase Microextraction (SPME)
- MOLECULAR IMPRINTING
- MAGNETIC NANOPARTICLES
- Definitions
- Characterization
- MSPE
- METAL ORGANIC FRAMEWORKS: THE NEW KIDS ON THE BLOCK
- How It All Began
- Structure, Synthesis and Stability
- De Novo Strategies
- Post-Synthetic Strategies
- Post Synthetic Modification (PSM)
- Hydrophobic Surface Treatment
- Post-Synthetic Exchange
- Post-Synthetic Elimination and Installation
- Tandem PSM
- Introduction of Functional Groups
- Engineering Porosity and Pores
- Improvement of Structural Stability
- Surface and Interior Modification
- Catalytic Activity
- Multiple Magnetic Regulations
- Hybrid Materials
- Applications: Welcome to the Multiverse
- Future Perspectives: To the Infinite and Beyond
- SUPRAMOLECULAR SOLVENTS
- CARBON SORBENTS
- THE JOURNEY SO FAR
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 3 QUALITATIVE AND QUANTITATIVE INVESTIGATION OF BIO TISSUES USING MICROSCOPY AND DATA MINING
Hafeez Ullah, Munir Akhtar and Muhammad Ramzan Khawar
- INTRODUCTION
- MARROW OF BONE
- Hematopoietic Stem Cell
- White Blood Cells
- Granulocytes
- Agranulocytes
- CANCER
- General Characteristics of Cancer Cells
- Classification of Blood Cancer
- Sugar and its Effect on the Body
- Role of Sugar in Cancer
- Effect of Sugar on Cancerous Leukocytes
- Salt and Immune System
- Effect of Salt on Cancerous WBCs
- PLATELETS
- Morphology of Platelets
- Platelets Adhesion, TCIPA and Effect of Glucose
- Effect of Salt on Platelets
- RED BLOOD CELLS
- Role of Erythrocytes
- Rouleaux Formation
- Effect of Sugar on the Rouleaux Formation
- Effect of Salt on Rouleaux Formation
- MICROSCOPY
- Principle of Optical Microscopy (OM)
- CCD Technique
- RESULTS AND DISCUSSIONS
- Effects of Glucose on the Aggregation of Leukocytes & Erythrocytes in Blood Cancer
- Method of Sample Preparation
- Discussions
- Effect of Glucose on Platelets in Blood Cancer
- Methodology and Sample Preparation
- Discussions
- Effect of Sodium Chloride on WBCs & RBCs in Blood Cancer
- Methodology & Sample Preparation
- Effect of Sodium Chloride on Platelets in Blood Cancer
- Method of Sample Preparation
- QUANTIFICATION OF SALT AND PURE WATER IN HUMAN WHOLE BLOOD USING LIGHT MICROSCOPE
- Introduction
- Materials and Methods
- Sample Set (1)
- Sample Set (2)
- Sample Set (3)
- Results
- Effect of Pure Salt on RBCs
- Effect of Distilled Water on RBCs
- Discussion
- CLASSIFICATION OF CHRONIC KIDNEY DISEASES AND LIVER CIRRHOSIS
- What is a Kidney?
- Renal Physiologies
- NEPHRONS
- FUNCTIONS OF KIDNEY
- SPECIFIC KIDNEY DISEASES
- Kidney Stone
- Nephrotic Syndrome
- Acute Renal Failure
- Pyelonephritis
- IMAGE PROCESSING
- Analog Image Processing
- Digital Image Processing
- Advantages of Digital Image Processing in Medical
- Steps of Image Processing
- MEDICAL IMAGING PROCESSING
- Structural Medical Images
- Functional Medical Images
- IMAGE CLASSIFICATION USING DATA MINING TECHNIQUE
- What will be the Data Mining?
- Application of Data Mining Technique
- Use of Data Mining in Field of Health
- WHAT IS A FEATURE EXTRACTION?
- Color Features
- Texture Features
- Shape Features
- Features
- METHODOLOGIES
- Characterization Software
- DATA MINING TECHNIQUE USED FOR MEDICAL IMAGES FEATURE EXTRACTION
- WEKA
- Advantages of Weka
- Results
- Extracted Parameter
- Abnormal Ultrasonic Kidney Images with Chronic Kidney Diseases
- Discussions
- Conclusion
- CLASSIFICATION OF LIVER CIRRHOSIS
- Liver Physiology and Diseases
- Anatomy and Function of Liver
- Diseases of Liver
- Causes of Liver Damage
- Liver Cancer
- Cirrhosis
- MEDICAL IMAGE ANALYSIS
- TEXTURE ANALYSIS TECHNIQUES
- Geometric and Topological Approach
- Second or Higher-order Statistics
- Texture Based on Gradient Information
- Materials and Methods
- Sample Preparation
- Selecting ROI
- Statistical Technique
- FIRST-ORDER STATISTICAL TEXTURE ANALYSIS
- Results
- Classification of Results
- Conclusion
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 4 ANALYTICAL TECHNIQUES FOR ANALYSIS OF METALS AND MINERALS IN THE SOIL SAMPLES
Snežana Filip, Saša Popov, Saša Šorgić and Saša Đurović
- INTRODUCTION
- CLASSIFICATION OF ANALYTICAL TECHNIQUES APPLIED FOR SOIL ANALYSIS 161 Quantitative Analysis
- Classical Analytical Techniques
- Instrumental Techniques
- PRETREATMENT OF THE SAMPLES
- Acid Digestion
- Single or Sequential Extraction Procedures
- Alternative Extraction Techniques
- INSTRUMENTAL TECHNIQUES
- Atomic Absorption Spectrometry (AAS)
- Inductively Coupled Plasma (ICP)
- Anodic Stripping Voltammetry (ASV)
- Neutron Activation Analysis (NAA)
- X-ray Fluorescence (XRF) Spectrometry and Induced X-ray Emission (PIXE)
- CONCLUSION
- CONSENT FOR PUBLICATION
- CONFLICT OF INTEREST
- ACKNOWLEDGEMENTS
- REFERENCES
CHAPTER 5 MONITORING THERAPEUTIC RESPONSE IN CANCERS: A RAMAN SPECTROSCOPY APPROACH
Kshama Pansare and C. Murali Krishna
- INTRODUCTION
- Raman Scattering
- Basic Theory
- Molecular Vibrations
- Raman Instrumentation
- Components of Raman Spectrometers
- Types of Raman Spectroscopy
- Resonance Raman Spectroscopy (RRS)
- Surface-Enhanced Raman Spectroscopy (SERS)
- Coherent Anti-Stokes Raman Spectroscopy (CARS)
- Stimulated Raman Spectroscopy (SRS)
- Spatially offset Raman Spectroscopy (SORS)
- Confocal Raman Microscopy
- Spectra Pre-Processing and Data Analysis
- Applications of Raman Spectroscopy
- CANCER
- Aetiology and Epidemiology of Cancer
- Epidemiology of Cancer
- Pathogenesis of Cancer
- Classification, Grading and Staging of Tumours
- Grading and Staging of Tumours
- Diagnosis of Cancer
- Treatment of Cancer
- Novel Approaches for Cancer Therapy
- Immunotherapy
- Cold Atmospheric Plasma (CAP) Therapy
- THERAPEUTIC MONITORING OF CANCERS
- Raman Spectroscopy in Therapeutic Monitoring of Cancers
- Raman Spectroscopy and Surgery
- Intraoperative Surgical Margin Assessment
- Malignancy-Associated Changes (MAC)/Cancer Field Effects (CFE)
- Cancer Recurrence Prediction
- Raman Spectroscopy and Radiotherapy
- Ex Vivo Biopsies
- In Vitro Cell Line and Xenograft Models
- Raman Spectroscopy and Chemotherapy
- Therapeutic Drug Monitoring (TDM)
- Chemoresistance
- Raman Spectroscopy and Novel Approaches for Cancer Therapy
- RAMAN SPECTROSCOPY AND ARTIFICIAL INTELLIGENCE (AI)
CONCLUSION
CONSENT FOR PUBLICATION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
REFERENCES
SUBJECT INDEX
Author
- Atta-ur-Rahman
- Sibel A. Ozkan

