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Enzyme Active Sites and their Reaction Mechanisms

  • Book

  • December 2020
  • Elsevier Science and Technology
  • ID: 5146439

Enzyme Active Sites and their Reaction Mechanisms provides a one-stop reference on how enzymes "work." Here, Dr. Harry Morrison, PhD and Professor Emeritus at Purdue University, provides a detailed overview of the origin and function of forty enzymes, the chemical details of their active sites, their mechanisms of action, and associated cofactors. The enzymes featured highlight a step forward, along with possible areas of application, thus supporting new research in academic and industrial labs. Each chapter is written in a clear format, including a brief summary of enzyme function and structure, a detailed description of their mechanisms of action and associated co-factors.

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Table of Contents

1. Acetylcholinesterase2. Aconitase3. Adenosine deaminase4. Alcohol dehydrogenase5. Aldehyde dehydrogenase6. Arginase7. Carbonic anhydrase8. Carboxypeptidase A9. Chymotrypsin10. Citrate synthase11. Cytochrome P450cam12. m5C Cytosine methyltransferase13. Deoxyribodipyrimidine photolyase14. Dihydrolipoamide dehydrogenase15. Dihydrolipoyl transacetylase16. Farnesyl pyrophosphate synthase17. Fructose-1,6-bisphosphate aldolase18. Hepatitis C NS2/3 protease19. HIV-1 protease20. Indoleamine-Dioxygenase-121. Lysozyme22. Methyl-coenzyme M reductase23. Methylmalonyl CoenzymeA Mutase24. Non-heme iron halogenase25. Peptidylarginine deiminase26. Peptidylglycine a-hydroxylating monooxygenase27. Phenylalanine hydroxylase28. Phosphatidylinositol-specific phospholipase C29. Protein kinase A30. Pyruvate carboxylase31. Pyruvate dehydrogenase32. Ribonucleotide reductase33. Ribonuclease A34. Serine racemase35. Soluble quinoprotein glucose dehydrogenase36. Tetrachloroethene reductive dehalogenase37. Thymidylate synthase38. 20S Proteasome39. Uracil-DNA Glycosylase40. Vanadium-dependent chloroperoxidase


Harry Morrison Emeritus Professor, Bio-organic Chemistry, Purdue University, West Lafayette, IN, USA. Harry Morrison, PhD is Emeritus Professor at Purdue University, West Lafayette, IN, USA. He joined the Purdue School of Science in 1963, and has since supervised nearly fifty Ph.D. students, and also served as Dean of the College of Science from 1992-2002. Dr. Morrison was instrumental in increasing the numbers and impact of women faculty in the College of Science. After earning a B.A. from Brandeis University in 1957 and a Ph.D. from Harvard in 1961, Dr. Morrison was a Postdoctoral Researcher at the Swiss Federal Institute in Zurich, Switzerland for two years, and following this was a Research Associate at the University of Wisconsin from 1962-1963. Dr. Morrison has published over 170 papers in peer reviewed journals and has edited two books on bioorganic chemistry.