This authoritative overview on an emerging topic in the molecular life sciences covers all aspects of the aging of (long-lived) proteins. It describes the molecular mechanisms of aging on the protein level, in particular the most common side chain modifications and includes analytical methods to study protein half-life and the accumulation of modifications. Finally, the impact of protein aging on several age-related disases in humans is dissected, and their role in limiting human lifespan is discussed.
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Dedication
Foreword
Series editor's preface
Preface
01 Long-lived cells and long-lived proteins in the human body
02 Imaging Mass Spectrometry of Long-Lived Proteins
03 Eye lens crystallins: remarkable long-lived proteins
04 Spontaneous breakdown of long-lived proteins in aging and their implications in disease
05 Modifications of Long-lived Proteins that affect Protein Solubility
06 Degradation of Long-lived proteins as a cause of Autoimmune diseases
07 How Isomerization and Epimerization in Long-lived Proteins Affects Lysosomal Degradation and Proteostasis
08 The Maillard Reaction. Protein Modification by Ascorbic Acid
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Roger J. W. Truscott
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