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Organic Reactions, Volume 100. Edition No. 1

  • ID: 5225856
  • Book
  • January 2020
  • 1136 Pages
  • John Wiley and Sons Ltd
Written by a "who is who" of leading organic chemists, this anniversary volume represent the Organic Reactions editors' choice of the most important, ground-breaking and versatile reactions in current organic synthesis. The 15 reaction types selected for this volume include reactions for carbon-carbon bond formation, cross-coupling reactions, hydro- and halofunctionalizations, among many others.
In line with the successful recipe of the series, each chapter is focused on a single reaction, discussing its mechanism and stereochemistry, scope and limitations, applications to synthesis, comparison with other methods, and experimental procedures. Each chapter concludes with a tabular survey of selected key application examples, complete with reported reaction conditions and yields, to serve as a quick reference guide for synthesis planning.
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1. The Negishi Cross-Coupling Reaction 1
Colin Diner and Michael G. Organ

2. Generation and Trapping of Functionalized Aryl- and Heteroarylmagnesium and -Zinc Compounds 63
Ferdinand H. Lutter, Maximilian S. Hofmayer, Jeffrey M. Hammann, Vladimir Malakhov, and Paul Knochel

3. Copper-Catalyzed, Enantioselective Hydrofunctionalization of Alkenes 121
Haoxuan Wang and Stephen L. Buchwald

4. The Catalytic, Enantioselective Favorskii Reaction: in Situ Formation of Metal Alkynylides and Their Additions to Aldehydes 207
Yeshua Sempere and Erick M. Carreira

5. Enantioselective Lithiation–Substitution of Nitrogen-Containing Heterocycles 255
Kevin Kasten, Nico Seling, and Peter O’Brien

6. Catalytic, Enantioselective, Transfer Hydrogenation 329
Masahiro Yoshimura and Masato Kitamura

7. Hydrofunctionalization of Alkenes by Hydrogen-Atom Transfer 383
Ryan A. Shenvi, Jeishla L. M. Matos, and Samantha A. Green

8. Carbon–Carbon Bond Formation by Metallaphotoredox Catalysis 471
Eric D. Nacsa and David W. C. MacMillan

9. Suzuki–Miyaura Cross-Coupling 547
Alexander B. Pagett and Guy C. Lloyd-Jones

10. ortho-Directed C–H Alkylation of Substituted Benzenes 621
Yusuke Ano and Naoto Chatani

11. Catalytic, Enantioselective, C–H Functionalization to Form Carbon–Carbon Bonds 671
Qing-Feng Wu, Gang Chen, Jian He, and Jin-Quan Yu

12. Catalytic, Enantioselective Fluorination Reactions 749
Richard T. Thornbury and F. Dean Toste

13. Catalyst-Controlled Glycosylation 801
Samuel M. Levi and Eric N. Jacobsen

14. Palladium-Catalyzed Amination of Aryl Halides 853
John F. Hartwig, Kevin H. Shaughnessy, Shashank Shekhar, and Rebecca A. Green

15. Catalytic, Enantioselective, Copper–Boryl Additions to Alkenes 959
Amir H. Hoveyda, Ming Joo Koh, Kyunga Lee, and Jaehee Lee

Cumulative Chapter Titles by Volume 1057

Author Index, Volumes 1–100 1075

Chapter and Topic Index, Volumes 1–100 1083

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