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Handbook of Proteolytic Enzymes. Metallopeptidases. Edition No. 4

  • Book

  • 808 Pages
  • September 2023
  • Elsevier Science and Technology
  • ID: 5230595
Handbook of Proteolytic Enzymes: Metallopeptidases, Fourth Edition has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes.This volume, Metallopeptidases, includes over 300 chapters on known metallopeptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases.

Table of Contents

1. Bacterial collagenase H
2. Afg3-like protein 2
3. YME1L1 protein
4. Oma1 peptidase
5. Csn5 peptidase
6. Spartan peptidase
7. RseP peptidase
8. RPN11 peptidase
9. Aminopeptidase N
10. Cystinyl aminopeptidase
11. Endoplasmic reticulum aminopeptidase 1
12. Angiotensin-converting enzyme-2
13. Thermolysin
14. Pseudolysin
15. Collagenase G/A (Clostridium histolyticum)
16. Matrix metallopeptidase-1
17. Matrix metallopeptidase-2
18. Matrix metallopeptidase-3
19. Matrix metallopeptidase-7
20. Matrix metallopeptidase-9
21. Matrix metallopeptidase-12
22. Matrix metallopeptidase-13
23. Membrane-type matrix metallopeptidase-1
24. Meprin
25. Procollagen C-peptidase
26. ADAM10 peptidase
27. ADAM17 peptidase
28. ADAMTS13 peptidase
29. Neprilysin
30. Bontoxilysin
31. Anthrax lethal factor
32. i-AAA peptidase
33. Dipeptidyl-peptidase III
34. Carboxypeptidase B2
35. Insulysin
36. Nardilysin
37. Xaa-Pro dipeptidase (eukaryote-type)
38. Glutamate carboxypeptidase
39. Glutamate carboxypeptidase II
40. Lysostaphin


Neil D. Rawlings Senior Scientist, Proteins Department, EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Currently Dr. Neil Rawlings is a Senior Scientist in the Proteins Department at the EMBL-European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridgeshire, UK. Dr. Rawlings has been an active researcher at the Wellcome Trust Sanger Institute for over twenty years. He is extremely well known in the proteolytic enzyme community for his work curating the MEROPS database, an information resource covering peptidases and the proteins that inhibit them, which is used by expert researchers and students worldwide. Dr. Rawlings has published widely in such peer reviewed journals as Genome Research, BMC Bioinformatics, PloS ONE, Nucleic Acids Research, the Journal of Biological Chemistry, and Science. David S. Auld Associate Professor of Pathology, Harvard, MA, USA. David S. Auld is Associate Professor of Pathology at Harvard in MA, USA.